an artificial bone

Abstract

The invention discloses an artificial bone, and belongs to the field of 3D printing materials. The artificial bone consists of the following components in parts by mass: 64-72 parts of nano hydroxy calcium phosphate / polycaprolactone / polylactic acid, 31-40 parts of poly(ether-ketone-ketone), 12-25 parts of mesenchymal stem cells, 42-57 parts of adipose tissue-derived stromal cells-protein hydrogel, 28-32 parts of nano beta-tricalcium phosphate and 15-21 parts of diluted citric acid. The artificial bone has the characteristics that the artificial bone is prepared by 3D printing, a stent for bearing cells and maintaining shapes of organs or tissues is printed, a cavity for allowing the tissues and the cells to grow is reserved in the support, when transplanted into an organism, the printed bone can survive and is fused with a transplantation recipient to form a whole body, and the material of the stent can be biodegraded and is non-toxic.

Description

technical field [0001] The invention relates to a 3D printing material, in particular to an artificial bone. Background technique [0002] Traditional bone repair or replacement methods include autologous bone grafting, allogeneic bone grafting, and bone lengthening, but these processes are time-consuming. With the development of science and technology, emerging bone tissue engineering scaffolds can replace traditional bone damage repair and replacement methods, and quickly perform bone repair. The preparation of existing bone tissue engineering scaffolds usually adopts solution casting / ion elution method, in situ forming method, electrospinning method, phase separation / lyophilization method, gas pore forming method, etc. These preparation methods have obtained comparative results. Satisfactory results, but unsatisfactory in terms of accuracy, pore uniformity, spatial structure complexity, and bracket customization. Although 3D printing of bones can be achieved by existing...

AI Technical Summary

Problems solved by technology

The preparation of existing bone tissue engineering scaffolds usually adopts solution casting / ion elution method, in situ forming method, electrospinning method, phase separation / lyophilization method, gas pore forming method, etc. These preparation methods have obtained comparative results. Satisfactory results, but unsatisfactory in terms of accuracy, uniformity of pores, complexity of spatial structure, individualization of scaffolds, etc.

Although 3D printing of bones can be achieved by existing technologies, due to the limitation of materials, it is impossible to print out living cell tissues, and the combination of cell tissues and scaffold materials allows the printed cells and tissues to survive until the bone is transplanted into the human body. Integrate with the transplant recipient