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Amide alkaloid compound in portulaca oleracea and extraction and separation method thereof

A separation method and compound technology, applied in chemical instruments and methods, sugar derivatives, sugar derivatives, etc., can solve the problems of low structural novelty, and achieve the effects of environmental protection process methods, simple and fast operation methods

Active Publication Date: 2017-01-04
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology

[0004] At present, most of the chemical components isolated from purslane are known, and the structural novelty is low. Therefore, the development and isolation of new compounds in purslane are urgently needed

Method used

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  • Amide alkaloid compound in portulaca oleracea and extraction and separation method thereof
  • Amide alkaloid compound in portulaca oleracea and extraction and separation method thereof
  • Amide alkaloid compound in portulaca oleracea and extraction and separation method thereof

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Embodiment 1

[0027] The invention provides a special amide alkaloid compound, the molecular formula is C 24 h 39 NO 7 , named oleraciamide C, the chemical structural formula is:

[0028]

[0029] The special amide alkaloid compound is named oleraciamide C according to the structure, and Table 1 is the NMR data of the alkaloid compound: 1 H-NMR with 13 C-NMR in deuterated methanol.

[0030] Table 1: NMR data of novel alkaloid compounds of the present invention

[0031]

[0032] see Figure 1-9 , The structure identification and deduction of the special amide alkaloid compound of the present invention.

[0033] Oleraciamide C: white oil, easily soluble in methanol, insoluble, slightly soluble in water. After spotting the sample on the silica gel thin-layer plate, the spots of the dilute bismuth iodide potassium test solution are orange, indicating that the compound is an alkaloid component, and the Molish reaction is positive, indicating that the compound contains sugar groups. ...

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Abstract

The invention relates to the field of Chinese medicine extraction and separation, in particular to a special amide alkaloid compound which is extracted, separated and identified from portulaca oleracea and an extraction and separation method thereof. The molecules of the new alkaloid compound are C24H39NO7 in sequence, and the new alkaloid compound is named after oleraciamide C. According to the extraction and separation method of the new alkaloid compound, 50% ethyl alcohol reflux extraction, macroporous absorbent resin chromatography, ethyl acetate extraction, polyamide column chromatography, silica column chromatography, Sephadex LH-20 purification and ODS medium-pressure column separation and purification are adopted in sequence, and therefore the new special amide alkaloid compound is successfully extracted and separated. The amide alkaloid compound has the effects of resistance to inflammation and tumors and neuroprotection. The amide alkaloid compound and salt or derivatives thereof can serve as primers of other compounds and raw materials for development of new drugs and research on pharmacological activity, and is used for preparing medicine or health-care products resisting inflammation and tumor and having neuroprotection.

Description

technical field [0001] The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to amide alkaloids extracted, separated and identified from purslane medicinal materials and an extraction and separation method thereof. Background technique [0002] Purslane (Portulaca oleracea L.), also known as longevity dish, horse amaranth, is a plant of the family Amaranthaceae. Purslane is drought and waterlogging resistant, light and shade resistant, widely distributed, and rich in resources. It has attracted much attention as a wild plant for both medicine and food. The 2015 edition of "Pharmacopia of the People's Republic of China" recorded the dry aerial parts of purslane as medicine. , has the functions of clearing away heat and detoxification, cooling blood to stop bleeding, and stopping dysentery. [0003] Modern pharmacological studies of purslane have shown that it has the functions of anti-inflammatory and analgesic, antib...

Claims

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Application Information

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IPC IPC(8): C07H9/02C07H1/08A61P29/00A61P35/00A61P25/00
CPCC07H1/08C07H9/02
Inventor 英锡相英哲铭徐靓张文洁张朝绅
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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