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Preparation method of porous alpha-TCP microballoon with anti-bacterial function

A technology of porous microspheres and microspheres, which is applied in medical science, prosthesis, tissue regeneration, etc., can solve the problems of complicated preparation process of porous α-TCP microspheres, shorten the preparation period, improve the therapeutic effect, and achieve uniform dispersion. Effect

Active Publication Date: 2017-02-01
湖北鑫甬生物环保科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve some deficiencies in current bone defect repair materials and the relatively complicated preparation process of porous α-TCP microspheres, the present invention provides a method for preparing porous α-TCP microspheres with antibacterial function. First, prepare α -The raw material of TCP is inorganic antibacterial agent compounded with polymers to prepare microspheres, and then prepared into porous microspheres through gradient sintering. The gas formed by its own reaction and the voids caused by the decomposition of polymers make antibacterial porous α-TCP microspheres The ball has a higher porosity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The steps of the preparation method of the porous α-TCP microspheres with antibacterial function are as follows:

[0021] (1) 73.2g (0.426mol) calcium hydrogen phosphate (CaHPO 4 2H 2 O) with 20g (0.2mol) calcium carbonate (CaCO 3 ) into the ethanol solution, then add 1.0g (0.006mol) zinc sulfate (ZnSO 4 ), ball milling for 0.5h, suction filtration, and vacuum drying to obtain CaH 2 PO 4 and CaCO 3 composite powder;

[0022] (2) Add 15g of gelatin to 100mL of water to prepare a gelatin solution, then add 15g of the above-mentioned composite powder into the gelatin solution, stir evenly to obtain a mixed solution, use a micro-syringe pump to squeeze the mixed solution in at a rate of 20mL / h In water with a temperature of about 4°C, a voltage of 5kV is applied to the needle, and the obtained composite microspheres of gelatin and composite powder are washed with ethanol, and then vacuum-dried at room temperature;

[0023] (3) Put the composite microspheres obtained ...

Embodiment 2

[0025] The steps of the preparation method of the porous α-TCP microspheres with antibacterial function are as follows:

[0026] (1) 73.2g (0.426mol) calcium hydrogen phosphate (CaHPO 4 2H 2 O) with 20g (0.2mol) calcium carbonate (CaCO 3 ) into the ethanol solution, and then add 3.0g (0.018mol) zinc sulfate (ZnSO 4 ), ball milling for 1h, suction filtration, and vacuum drying to obtain CaH 2 PO 4 and CaCO 3 composite powder;

[0027] (2) Add 35g of gelatin to 100mL of water to prepare a gelatin solution, then add 87.5g of the above-mentioned composite powder into the gelatin solution, stir evenly to obtain a mixed solution, use a micro-injection pump to squeeze the mixed solution at a rate of 50mL / h into a low-temperature coagulation bath, and at the same time apply a voltage of 20kV on the needle, and the obtained composite microspheres of gelatin and composite powder are washed with ethanol, and then vacuum-dried at room temperature;

[0028] (3) Put the composite mic...

Embodiment 3

[0030] The steps of the preparation method of the porous α-TCP microspheres with antibacterial function are as follows:

[0031] (1) 73.2g (0.426mol) calcium hydrogen phosphate (CaHPO 4 2H 2 O) with 20g (0.2mol) calcium carbonate (CaCO 3 ) into the ethanol solution, then add 5.0g of zinc sulfate (ZnSO 4 ) (0.030mol), ball milling for 1h, suction filtration, and vacuum drying to obtain CaH 2 PO 4 and CaCO 3 composite powder;

[0032] (2) Add 25g of gelatin to 100mL of water to prepare a gelatin solution, then add 50g of the above composite powder into the gelatin solution, stir evenly to obtain a mixed solution, use a micro-syringe pump to squeeze the mixed solution into the solution at a rate of 30mL / h In the low-temperature coagulation bath, a voltage of 15kV is applied to the needle at the same time, and the obtained composite microspheres of gelatin and composite powder are washed with ethanol and then vacuum-dried at room temperature;

[0033](3) Put the composite m...

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Abstract

The invention discloses a preparation method of a porous alpha-TCP microballoon with an anti-bacterial function. The method comprises the following steps of (1) ball-milling monocalcium phosphate, calcium carbonate and zinc sulfate, uniformly mixing, and drying to prepare composite powder;(2) preparing a gelatin solution, preparing gelatin according to a certain proportion, uniformly mixing the gelatin and the composite powder, utilizing an electrostatic drop generation method for preparing a gelatin and composite powder microballoon;(3) sintering the gelatin and composite powder microballoon step by step to obtain the porous alpha-TCP microballoon with the anti-bacterial function. The method for preparing the porous alpha-TCP microballoon provided by the invention is simpler, the preparation efficiency is higher, and meanwhile, the porous alpha-TCP microballoon has higher porosity and has a certain anti-bacterial function, can be applicable to treatment of infected bone defects, and is wider in application prospect.

Description

technical field [0001] The invention belongs to the field of bone defect repair, in particular to a simple preparation method and application of porous α-TCP microspheres with antibacterial function. Background technique [0002] Bone is one of the most important tissues in the human body. It protects internal organs, provides attachment for muscles, and produces blood cells. At present, there are countless patients with orthopedic diseases such as myelitis, bone tuberculosis, and infectious bone defects caused by trauma, aging, exercise, inflammation, tumors, and congenital deformities, which have brought great harm to human health. , has always been a clinical problem in orthopedics. Bone repair material is a new type of material that can replace or repair human diseased bone tissue and realize regeneration function. Therefore, there is a great demand for bone repair materials. At present, there are various materials for bone defect repair, among which α-tricalcium phosp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/12A61L27/02A61L27/22A61L27/54A61L27/50
CPCA61L27/025A61L27/12A61L27/222A61L27/50A61L27/54A61L27/56A61L2300/404A61L2430/02C08L89/00
Inventor 于翔徐茜杨柳张浩王娜杨秀琴宋会芬
Owner 湖北鑫甬生物环保科技有限公司