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Compound micro-porous cross-linked starch styptic powder

A technology of cross-linked starch and hemostatic powder, applied in the field of medical supplies, can solve the problems of limited utilization rate, slow water absorption of starch microspheres, complicated process, etc., and achieve the effect of accelerating activation and shortening coagulation time.

Active Publication Date: 2017-02-08
JIANGSU HUANENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the hemostatic effect is excellent, but first, because its cross-linking agent is epichlorohydrin, it will release potential toxic substances when it degrades; second, the water absorption rate is not very high, so the hemostatic effect needs to be improved; third, the price is too high. Too high, limiting its usage
Document "Using Potato Starch to Prepare Hemostatic Material Method" (Health and Medical Equipment, March 2014, Volume 35, No. 3, 23-25), using potato starch as raw material, through the methods of gelatinization, enzymatic hydrolysis and crosslinking Potato starch hemostatic powder is prepared, the process is more complicated, and the prepared starch microspheres absorb water slowly, and the hemostatic effect of using a single potato starch is not good

Method used

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  • Compound micro-porous cross-linked starch styptic powder
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Examples

Experimental program
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Effect test

Embodiment 1

[0030] The preparation method of the composite microporous cross-linked starch hemostatic powder of this embodiment is as follows:

[0031] ① Take 10g of starch, add 200ml of purified water and stir until gelatinized, then add 10g of sodium carboxymethylcellulose, and use NaOH to adjust the pH to 7.

[0032] ②Put 750ml of liquid paraffin into the reaction kettle, and when the temperature rises to 75°C, add a mixture of 20ml of Span 80 and 30ml of Tween 80.

[0033] ③ Mix ① into ②, add 10ml of glutaraldehyde to react for 8 hours, and take out the material.

[0034] ④ Add absolute ethanol and ethyl acetate to separate the material, pour off the upper oil phase, repeat washing with absolute ethanol, suction filter 3 times, dry in an oven, grind, sieve, pack, and sterilize.

Embodiment 2

[0036] The preparation method of the composite microporous cross-linked starch hemostatic powder of this embodiment is as follows:

[0037] ① Take 10g of starch, add 800ml of purified water and stir until gelatinized, then add 0.1g of sodium alginate, and use NaOH to adjust the pH to 9.

[0038] ②Put 150ml of vegetable oil into the reaction kettle, and when the temperature rises to 65°C, add a mixture of 2ml of Span 80 and 3ml of Tween 80.

[0039] ③ Mix ① into ②, add 15g of sodium trimetaphosphate to react for 16 hours, and take out the material.

[0040] ④ Add absolute ethanol and ethyl acetate to separate the material, pour off the upper oil phase, repeat washing with absolute ethanol, suction filter 3 times, dry in an oven, grind, sieve, pack, and sterilize.

Embodiment 3

[0042] The preparation method of the composite microporous cross-linked starch hemostatic powder of this embodiment is as follows:

[0043] ① Take 10g of starch, add 500ml of purified water and stir until gelatinized, then add 5g of sodium carboxymethylcellulose, and use NaOH to adjust the pH to 11.

[0044] ②Put 500ml of vegetable oil into the reaction kettle, and when the temperature rises to 70°C, add a mixture of 10ml of Span 80 and 10ml of Tween 80.

[0045] ③ Mix ① into ②, add 20ml of epichlorohydrin to react for 24 hours, and take out the material.

[0046] ④ Add absolute ethanol and ethyl acetate to separate the material, pour off the upper oil phase, repeat washing with absolute ethanol, suction filter 3 times, dry in an oven, grind, sieve, pack, and sterilize.

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Abstract

The invention provides compound micro-porous cross-linked starch styptic powder which is prepared by emulsification and cross-linking of one of purified water, potato starch, sodium alginate and sodium carboxymethyl cellulose, an emulsifying agent, a cross-linking agent and a dispersing agent as raw materials, wherein the emulsifying agent is selected from Span and Tween; the cross-linking agent is selected from glutaric dialdehyde, sodium trimetaphosphate, formaldehyde and epoxy chloropropane; and the dispersing agent is selected from paraffin and vegetable oil. The compound micro-porous cross-linked starch styptic powder has the following technical effects: micro-porous starch styptic materials are spherical particles extracted from plant starch and subjected to micro-porous treatment; when micro-porous polysaccharide styptic particles are put on a bleeding wound, the molecules of the particles absorb moisture in blood, and visible components in the blood are aggregated on the surfaces of the particles so as to form a gelatinous mixture, thereby achieving the effect of stopping bleeding in time; and meanwhile, activation of endogenous blood coagulation factors is accelerated, the blood coagulation time is shortened, a local clot is formed, and the styptic effect is finished within tens of seconds.

Description

technical field [0001] The invention relates to a composite microporous cross-linked starch hemostatic powder, which belongs to the technical field of medical supplies. Background technique [0002] Hemostasis plays a particularly important role in surgical operations. A series of postoperative complications due to excessive bleeding not only increases the difficulty of the doctor's work, but also makes the patient bear great risks during or after the operation. . This makes a series of local hemostatic materials emerge as the times require. At present, the hemostatic materials on the market mainly include gelatin, collagen, oxidized cellulose, regenerated oxidized cellulose, and starch microspheres. Among them, gelatin and collagen products are prepared from animal-derived raw materials, which have long absorption time and high tissue inflammatory reaction rate; oxidized cellulose and regenerated oxidized cellulose are made of plant cellulose, although the tissue reaction...

Claims

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Application Information

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IPC IPC(8): A61L24/08A61L24/00
CPCA61L24/0036A61L24/0042A61L24/08A61L2400/04C08L3/02C08L5/04C08L1/286
Inventor 蔡迪霞
Owner JIANGSU HUANENG PHARMA
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