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Preparation method of photocurable phosphorylcholine polymer

A phosphorylcholine and polymer technology, which is applied in the field of preparation of photocurable phosphorylcholine polymers, can solve problems such as shedding, and achieve the effects of mild conditions, broad application prospects, and simple preparation methods

Inactive Publication Date: 2017-02-08
XIAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the phosphorylcholine group is highly hydrophilic, and the phosphorylcholine polymer coating physically coated on the surface of the material is prone to dissolution, degradation, and even shedding in complex physiological environments.

Method used

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  • Preparation method of photocurable phosphorylcholine polymer
  • Preparation method of photocurable phosphorylcholine polymer
  • Preparation method of photocurable phosphorylcholine polymer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The preparation method of the photocurable phosphorylcholine polymer of the present embodiment comprises the following steps:

[0031] Step 1. Dissolve 10mmol 2-methacryloyloxyethylphosphorylcholine and 10mmol styrene in methanol and mix them uniformly to obtain a mixed solution of monomers. 2 Protection, preheat the mixed solution of monomers at 70°C for 30 minutes, then add 0.1 mmol of azobisisobutyronitrile, react for 20 hours at 70°C with stirring, concentrate the reaction solution after the reaction, and use a molecular weight cut-off of 6000-8000D The dialysis bag was dialyzed, and the dialyzed sample was freeze-dried at -50°C to obtain a phosphorylcholine polymer containing a benzene ring;

[0032] Step 2. Dissolve 0.2 g of the phenyl ring-containing phosphorylcholine polymer described in step 1 with 30 mL of a mixed solvent, then add 0.2 g of zinc chloride and 5 mL of chloromethyl ether to the dissolved solution, and at 40° C. After reacting for 15 hours, filte...

Embodiment 2

[0037] The preparation method of the photocurable phosphorylcholine polymer of the present embodiment comprises the following steps:

[0038] Step 1. Dissolve 6mmol of acryloyloxyethylphosphorylcholine and 14mmol of styrene in methanol and mix uniformly to obtain a mixed solution of monomers. 2 Protection, preheat the mixed solution of the monomers under the condition of stirring at 75°C for 30min, then add 0.1mmol of azobisisobutyronitrile to react, under the condition of stirring at 75°C for 20h, concentrate the reaction solution after the reaction, and use a molecular weight cut-off of 6000~8000D The dialysis bag was dialyzed, and the dialyzed sample was freeze-dried at -50°C to obtain a phosphorylcholine polymer containing a benzene ring;

[0039] Step 2. Dissolve 0.2 g of the phenyl ring-containing phosphorylcholine polymer described in step 1 with 30 mL of a mixed solvent, then add 0.2 g of zinc chloride and 5 mL of chloromethyl ether to the dissolved solution, and at 40° ...

Embodiment 3

[0043] The preparation method of the photocurable phosphorylcholine polymer of the present embodiment comprises the following steps:

[0044] Step 1. Dissolve 8mmol 2-methacryloyloxyethylphosphorylcholine and 12mmol styrene in methanol and mix them uniformly to obtain a mixed solution of monomers. 2 Protection, preheat the mixed solution of monomers at 80°C for 30 minutes, then add 0.1 mmol of azobisisobutyronitrile, react at 80°C for 12 hours, concentrate the reaction solution after the reaction, and use a molecular weight cut-off of 6000-8000D The dialysis bag was dialyzed, and the dialyzed sample was freeze-dried at -50°C to obtain a phosphorylcholine polymer containing a benzene ring;

[0045] Step 2. Dissolve 0.2 g of the phenyl ring-containing phosphorylcholine polymer described in step 1 with 30 mL of a mixed solvent, then add 0.2 g of zinc chloride and 5 mL of chloromethyl ether to the dissolved solution, and dissolve at 30° C. After reacting for 10 hours, filter, and...

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Abstract

The invention discloses a preparation method of a photocurable phosphorylcholine polymer, comprising the following steps: Step 1, carrying out free radical polymerization on a styrene monomer and a vinyl monomer containing a phosphorylcholine group under the action of an initiator so as to obtain a phosphorylcholine polymer containing phenyl ring; Step 2, mixing zinc chloride, chloromethyl ether and the phosphorylcholine polymer containing phenyl ring to carry out chloromethylation so as to obtain a chloromethylated phosphorylcholine polymer; and Step 3, carrying out nucleophilic substitution on the chloromethylated phosphorylcholine polymer by the use of sodium azide under the alkaline condition so as to obtain the photocurable phosphorylcholine polymer. The preparation method is simple and the conditions are mild. The invention provides a new approach to obtaining of the photocurable phosphorylcholine polymer. The invention is of great academical significance for modification of biocompatibility of biological materials. The prepared photocurable phosphorylcholine polymer will have a wide application prospect in fields of material implantation in vivo, tissue engineering, drug sustained release and biosensor, etc.

Description

technical field [0001] The invention belongs to the technical fields of material surface science and biomedical polymer materials, and in particular relates to a preparation method of photocurable phosphorylcholine polymer. Background technique [0002] When the material is used in a living body, it is easy to non-specifically adsorb proteins, activate complement molecules and the immune system, thereby causing blood coagulation, immune and inflammatory reactions, resulting in a significant decrease in its performance or even failure. This is due to the poor biocompatibility of materials, therefore, biocompatibility research has become the primary issue in the field of biomaterial research. The surface of a material is the medium through which the material contacts the organism. Surface charge, hydrophilicity / hydrophobicity, chemical composition, and morphology are important factors that affect the interface interaction between the material and the organism, and determine wh...

Claims

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Application Information

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IPC IPC(8): C08F230/02C08F212/08C08F8/24C08F8/30A61L31/04A61L31/16A61L31/14A61L27/16A61L27/50A61L27/54
CPCA61L27/16A61L27/50A61L27/54A61L31/048A61L31/14A61L31/16C08F8/24C08F8/30C08F212/08C08F230/02C08F2800/10C08L25/08C08L43/02
Inventor 宫铭
Owner XIAN UNIV OF SCI & TECH
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