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Quality detection method of furan sophora berberine tablets

A quality detection method, the technology of ginseng berberine, applied in the field of detection of furan flavescens and berberine tablets, can solve the problems that the content of furazolidone cannot be accurately detected, animal food cannot be detected, and the content of flavescens cannot be grasped, etc., to achieve The effect of small error, good reproducibility and convenient detection

Inactive Publication Date: 2017-02-15
JILIN NORMAL UNIV
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Problems solved by technology

However, the detection process of this detection method is too cumbersome, and it is still impossible to accurately detect the content of furazolidone, and it is impossible to grasp the content of Sophora flavescens.
[0004] At present, the Ministry of Agriculture of the People's Republic of China has listed furazolidone as a prohibited drug and shall not be detected in animal food

Method used

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  • Quality detection method of furan sophora berberine tablets
  • Quality detection method of furan sophora berberine tablets
  • Quality detection method of furan sophora berberine tablets

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Embodiment 1

[0046] 1. Preparation of standard solution

[0047] 1.1 Preparation of furazolidone standard solution: Accurately weigh 7.09mg of furazolidone standard substance, put it in a 100mL brown volumetric flask, and use N, N dimethylformamide: absolute ethanol = 2:3 mixed solution to adjust the volume to the position of the mark line place, shake well; accurately measure 2ml to 10mL brown volumetric flask, use N, N dimethylformamide: anhydrous ethanol = 2:3 mixed solution to set the volume to the position of the scale line, shake well; the obtained concentration 14.18μg·mL -1 Furazolidone standard solution;

[0048] 1.2 Preparation of berberine hydrochloride standard solution: Accurately weigh 8.24 mg of berberine hydrochloride standard product, dissolve it in a 100 mL brown volumetric flask, and use a mixed solution of N, N dimethylformamide: absolute ethanol = 2:3 Dilute to the scale line, shake well; accurately measure 2ml to 10mL brown volumetric flask, use N, N dimethylformami...

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Abstract

The invention relates to a quality detection method of furan sophora berberine tablets. The quality detection method adopts high performance liquid chromatography to detect content of fruazolidone and specifically includes the steps of 1), preparation of a furazolidone standard solution; 2), preparation of a furazolidone test sample solution; 3), preparation of furazolidone negative sample solution; 4), chromatographic conditions: adoption of an amino chromatographic column Inertsil NH2 5umm 4.6*250mm C / N 5020-05546, mobile phase: acetonitrile:ethyl alcohol:2% of a phosphoric acid solution=92:6:2, average flow velocity: 1.0mL'min<1>, column temperature: 30DDEG C, detection wavelength: furazolidone 365nm, sample size: 10umL, detector: a VWD (variable wavelength detector); 5), refined absorption of standard solution, test sample solution and negative sample solution for 10uml respectively, injection of liquid chromatography and 7-minute recording of a chromatogram map. The quality detection method is high in detection accuracy, small in error and good in repeatability.

Description

technical field [0001] The invention relates to the technical field of drug detection, in particular to a detection method for furan sophora flavescens and berberine tablets. Background technique [0002] Furan Kushen Berberine Tablets are antibacterial and anti-inflammatory drugs, used for acute bacillary dysentery, enteritis, etc. The prescription of furan sophora flavescens and berberine tablets is 31.5g of furazolidone, 150g of flavescens liquid extract, 32.5g of berberine and appropriate amount of auxiliary materials to make 1000 tablets. This standard is included in the National Drug Standard WS-10001-(HD-1499)-2004 of the State Food and Drug Administration. The original standard content determination has only one component, furazolidone, which is determined by the ultraviolet absorption coefficient method. However, because the prescription is made by Composed of multi-component medicines, the original standard uses 10 tablets of this product, remove the coating, weig...

Claims

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Application Information

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IPC IPC(8): G01N30/02
CPCG01N30/02
Inventor 孙艳涛赵磊毕淑云王丽乔春玉
Owner JILIN NORMAL UNIV
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