Bone tissue engineering timbering material and preparation method thereof

A technology for bone tissue engineering and scaffolding materials, applied in the field of materials science, can solve the problems of unfavorable cell growth, low mechanical strength, etc., and achieve the effects of firm bonding, little impact on human body pH, and improved strength

Inactive Publication Date: 2017-02-22
UNIV OF SHANGHAI FOR SCI & TECH
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  • Abstract
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Problems solved by technology

[0012] Aiming at the above-mentioned technical problems in the prior art, the present invention provides a bone tissue engineering scaffold material and a preparation method thereof. The bone tissue engineering scaffold material and the preparation method thereof shall solve the problem of bone tissue engineering in the prior art. The mechanical strength of the scaffold material is not high, and it is not conducive to the technical problems of cell growth

Method used

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  • Bone tissue engineering timbering material and preparation method thereof
  • Bone tissue engineering timbering material and preparation method thereof
  • Bone tissue engineering timbering material and preparation method thereof

Examples

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Embodiment

[0036] Add hydroxyapatite powder to absolute ethanol for 10 minutes of ultrasonic dispersion to obtain a suspension containing hydroxyapatite powder with a mass percentage concentration of 10%; dissolve stearic acid in 60°C absolute ethanol to prepare a mass percentage concentration 10% stearic acid solution. Then, according to the volume ratio of the hydroxyapatite suspension to the stearic acid solution of 1:1 to 3, the stearic acid solution was added to the 60°C hydroxyapatite powder suspension in the electromagnetic stirring state, and the heating and stirring were continued to make the modified The activating agent and the hydroxyapatite powder were fully reacted, the solvent was removed by suction filtration, and vacuum-dried at 60° C. for 24 hours to obtain the modified hydroxyapatite powder.

[0037] Mix dichloromethane and dimethylformamide at a volume ratio of 7:3 to form a mixed solvent. The poly-L-lactic acid is dissolved in a mixed solvent to prepare a solution w...

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Abstract

The invention discloses a bone tissue engineering timbering material, which is a composite fiber membrane prepared from hydroxyapatite powder modified by stearic acid and poly-L-Lactic acid; in the composite fiber membrane, the mass ratio concentration of the hydroxyapatite powder modified by the stearic acid is 1-15%. The invention also provides a preparation method for the bone tissue engineering timbering material and comprises the following three steps: carrying out surface modification on the hydroxyapatite powder by the stearic acid, blending the hydroxyapatite powder and a poly-L-Lactic acid solution, and carrying out electrostatic spinning on a blending solution. The bone tissue engineering timbering composite fiber membrane has a porous communication structure, the hydroxyapatite powder and polylactic acid matrix are firmly combined, the hydroxyapatite powder is unlikely to fall in a degradation process, a degradation product slightly influences the power of hydrogen of a human body, and the porous structure is favorable for the transmission and the like of nutrition and metabolin, which is superior to traditional materials.

Description

technical field [0001] The invention belongs to the field of materials science, and relates to a bone tissue engineering support material and a preparation method thereof. Background technique [0002] Bone tissue engineering has significant advantages in the treatment of clinical bone defects. The three basic elements of bone tissue engineering are seed cells, signaling factors and scaffold materials. The process of bone tissue engineering is generally to transplant well-cultured seed cells in vitro to a suitable scaffold material to continue culturing. After a period of time, new bone is formed, and the scaffold material is degraded, finally achieving the purpose of repairing bone defects. As an important part of bone tissue engineering, scaffold materials play an important role in the whole process. [0003] The ideal scaffold material for bone tissue engineering should meet the following conditions: (1) Biocompatibility and surface activity: it is conducive to cell adhe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/18A61L27/56A61L27/54
CPCA61L27/12A61L27/18A61L27/54A61L27/56A61L2300/112A61L2300/412A61L2430/02C08L67/04
Inventor 马凤仓刘平刘新宽李伟陈小红张柯何代华杨丽红朱坚民
Owner UNIV OF SHANGHAI FOR SCI & TECH
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