Cooperative medicament level sodium alginate and alginate-originated oligosaccharide technological method

A technology of algin oligosaccharides and algin, which is applied in the direction of fermentation, etc., can solve the problems of not meeting the use standards of pharmaceutical grade algin and high content of heavy metals, and achieve the effect of low endotoxin, low content of heavy metals, and increased ratio

Active Publication Date: 2017-02-22
QINGDAO BRIGHT MOON SEAWEED GROUP
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, algin itself has a strong ability to adsorb heavy metals. The end product of the existing algin production tec...

Method used

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  • Cooperative medicament level sodium alginate and alginate-originated oligosaccharide technological method

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Effect test

Embodiment 1

[0034] Pharmaceutical grade alginate and alginate oligosaccharides were prepared as follows:

[0035] (1) 100 kg of dried kelp, soaked in 1.5m³ of water for 3 hours to make the kelp fully soaked and swelled, cut into 5cm strips with a vegetable cutter after controlling the water, and washed three times.

[0036] (2) Put the washed kelp into a digester, add 300 kg of tap water, add 12 kg of sodium fluoride under stirring, keep it warm at 60°C for 3 hours, break the kelp into a viscous state by mechanical means, and obtain Kelp digestive glue.

[0037] (3) Add 10 cubic meters of water to the kelp digestive juice obtained in step 2 to dilute, use compressed air to foam the glue, float and let stand for 2 hours after foaming.

[0038] (4) After coarsely filtering the glue solution obtained in step 3 through a centrifuge, add 20 kg of diatomaceous earth, filter it with a plate and frame filter press to obtain a clear solution, and use NaOH to adjust the pH of the glue solution to ...

Embodiment 2

[0047] (1) 100 kg of dried kelp, soaked in 1.5m³ of water for 3 hours to make the kelp fully soaked and swelled, cut into 5cm strips with a vegetable cutter after controlling the water, and washed three times.

[0048] (2) Put the washed kelp into a digester, add 300 kg of tap water, add 15 kg of sodium carbonate under stirring, and react at a constant temperature of 60°C for 4 hours, break the kelp into a viscous state with a machine, and obtain kelp digestion Glue.

[0049] (3) Add 10 m³ of water to the kelp digestive juice obtained in step 2 to dilute, use compressed air to foam the glue, float and stand for 2 hours after foaming.

[0050] (4) After coarsely filtering the glue solution obtained in step 3 through a centrifuge, add 20 kg of diatomaceous earth, and press filter with a plate and frame filter press to obtain a clear solution.

[0051] (5) Add 50 kg of activated carbon to the clear liquid obtained in step 4, and keep stirring for 60 minutes at 50°C.

[0052] (6...

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Abstract

The application discloses cooperative medicament level sodium alginate and alginate-originated oligosaccharide technological method, wherein the provided steps include taking dry sodium alginate and leaching, digesting, diluting, foaming, floating, and primary fine filtrating, and resulting in clear solution C, exploiting soda solution and regulating pH, adding activated charcoal in the clear solution C and tarnishing through absorption, then fine filtrating two stage through a closed frame filter and paper board filter, conducting weight metal absorption of the filtrating solution through ion exchange resin, and resulting in clear solution F, acidifying, dewatering, rinsing the clear solution F, partially degrading and decomposing by adding lyase, centrifugally separating undissolved acid block, solid neutralizing to result in medicament level sodium alginate, mist spray drying the filtration solution and resulting in alginate-originated oligosaccharide. The composite yield of the two types of products is high, the weight metal content of sodium alginate is low, the endotoxin is low, the weight metal content of alginate-originated oligosaccharide is low, the cooperative medicament level sodium alginate and alginate-originated oligosaccharide technological method satisfies applications in cosmetic industry.

Description

technical field [0001] The invention belongs to the technical field of seaweed chemical industry, and in particular relates to a process capable of co-producing pharmaceutical-grade alginate and alginate oligosaccharide. Background technique [0002] Alginate is a substance extracted and separated from brown algae, and it is a white or light yellow powder. Alginate is composed of mannuronic acid (M) and guluronic acid (G) in different proportions. The M / G ratio is generally determined by the raw materials. The ratio of M / G prepared from macroalgae is 0.842-1.66. The M / G ratio of alginate prepared from kelp is 2.15-2.35. The gel formed by the alginate product with a higher M / G ratio is softer, which is more in line with market demand, but a large number of literatures show that changing the ratio of M / G is often at the expense of raw material yield. In addition, some pharmaceutical grade alginate currently require low endotoxin, low heavy metals, and low viscosity. However...

Claims

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Application Information

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IPC IPC(8): C08B37/04C12P19/04
CPCC08B37/0003C08B37/0084C12P19/04
Inventor 王发合姜进举赵洪涛王暖升韩军
Owner QINGDAO BRIGHT MOON SEAWEED GROUP
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