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Composite bacterial cellulose dressing and preparation method based on controllable nanofiber spatial structure

A technology of fiber spatial structure and bacterial cellulose, applied in bacteria, bandages, drug delivery, etc., can solve the problems of fast water loss rate and high water vapor transmission rate, so as to enhance the intermolecular force and control the microenvironment of the wound , Low endotoxin effect

Active Publication Date: 2022-07-12
FUJIAN CHANGLE CITY CHANGYUAN TEXTILE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there are also some problems with BC skin repair materials: the current X and X PHMB products require a secondary dressing when in use
Although it has been reported that the nano-network structure on the surface of BC can prevent bacterial invasion, but its water vapor transmission rate is relatively high, and the water loss rate is relatively fast when there is no secondary dressing.

Method used

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  • Composite bacterial cellulose dressing and preparation method based on controllable nanofiber spatial structure

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Embodiment 1

[0049] A preparation method of a composite bacterial cellulose dressing based on a controllable nanofiber spatial structure, the steps are as follows:

[0050] (1) Dissolve gelatin particles (content 1 wt%) and bovine serum albumin (content 0.2 wt%) in deionized water, stir at 35° C. for 1 h, add citric acid to adjust the pH to 5, and obtain Gelatin-based aqueous solutions;

[0051] (2) adding the gelatin-based aqueous solution dropwise to the non-woven material containing the protein component, and naturally drying, to obtain a composite non-woven material with a gelatin-based component content of 0.1 wt%; wherein the natural drying is drying at room temperature for 12 hours; containing The gram weight of the non-woven material of the protein ingredient is 40g / m2 2 , is obtained by spunlace non-woven processing of medical staple fibers with an average diameter of 5 μm containing protein components (content 0.1wt%); medical staple fibers containing protein components In the ...

Embodiment 2

[0071] A preparation method of a composite bacterial cellulose dressing based on a controllable nanofiber spatial structure, the steps are as follows:

[0072] (1) Dissolve gelatin granules (content 1.3 wt%) and bovine serum albumin (content 0.4 wt%) in deionized water, stir at 37°C for 2 h, add citric acid to adjust pH to 5, to obtain a gelatin-based aqueous solution;

[0073] (2) adding the gelatin-based aqueous solution dropwise to the non-woven material containing the protein component, and naturally drying, to obtain a composite non-woven material with a gelatin-based component content of 0.5 wt%; wherein the natural drying is drying at room temperature for 48h; containing The gram weight of the non-woven material of the protein ingredient is 70g / m2 2 , is obtained by spunlace non-woven processing of medical staple fibers with an average diameter of 10 μm containing protein components (content 3wt%); medical staple fibers containing protein components Fiber (Lyocell fib...

Embodiment 3

[0093] A preparation method of a composite bacterial cellulose dressing based on a controllable nanofiber spatial structure, the steps are as follows:

[0094] (1) Dissolve gelatin particles (content 1.5 wt%) and bovine serum albumin (content 0.6 wt%) in deionized water, stir at 40° C. for 3 h, add acetic acid to adjust the pH to 5, and obtain Gelatin-based aqueous solutions;

[0095] (2) The gelatin-based aqueous solution was added dropwise to the non-woven material containing the protein component, and dried in an oven to obtain a composite non-woven material with a gelatin-based component content of 1 wt%; the oven drying temperature was 35 ° C, and the time was 1 h ;The gram weight of non-woven materials containing protein ingredients is 100g / m2 2 , is obtained by spunlace non-woven processing of medical staple fibers with an average diameter of 20 μm containing protein components (content is 5wt%); medical staple fibers containing protein components are reduced keratin s...

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Abstract

The invention relates to a composite bacterial cellulose dressing with a controllable nanofiber spatial structure and a preparation method. First, a gelatin-based aqueous solution is added dropwise to a non-woven material containing protein components, and after drying, cultured bacteria are added dropwise onto it. After the composite non-woven material adsorbs and cultivates the bacterial liquid and is saturated, adding the fermentation medium for static culture, and finally immersing the composite obtained from static culture in a triton aqueous solution with a concentration of 0.1-1 wt% for purification and drying. A non-woven material composite bacterial cellulose dressing is obtained; the prepared dressing has a sparse and dense structure, specifically, nanofibers of bacterial cellulose are distributed on the non-woven micron fibers, and the distribution and density of the nanofibers are adjustable. The non-woven material composite bacterial cellulose dressing prepared by the invention has good biocompatibility, mechanical properties and wound exudate absorption performance, and has huge applications in the biomedical fields such as wound dressings, human body repair materials and tissue engineering materials. prospect.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to a composite bacterial cellulose dressing with a controllable nanofiber spatial structure and a preparation method thereof, in particular to a composite bacterial cellulose dressing with a controllable nanofiber spatial structure and a preparation method thereof . Background technique [0002] Human skin is the largest organ of the human body and the natural barrier of the human body. It plays an important role in maintaining the stability of the internal environment and preventing the invasion of microorganisms. People inevitably cause many kinds of wounds in production and life. The use of dressings to cover exposed wounds is a commonly used method of wound treatment in clinical practice. A wound dressing with excellent performance can play part of the function of the skin, provide a moist environment conducive to wound healing, and even play a protective role agains...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/32A61L15/28A61L15/42C12N1/20C12P19/04
CPCA61L15/32A61L15/28A61L15/42C12P19/04C12N1/20A61L2400/12C08L89/00C08L1/02
Inventor 李喆孙卫华王姣生俊露姚勇波尹岸林于利超李海东吕向国
Owner FUJIAN CHANGLE CITY CHANGYUAN TEXTILE
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