Method for controlling temperature of glycine cooling crystallization crystal point

A technology of crystallization point temperature and cooling crystallization, which is applied in the investigation stage/state change, etc., can solve the problems of high equipment requirements, lower process yield, and small adjustable range, and achieve the effect of easy preparation and optimized process

Inactive Publication Date: 2017-02-22
HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The concentration of the crystallization mother liquor can control the temperature of the crystallization point in a wide range. The higher the concentration of the crystallization mother liquor, the higher the temperature of the crystallization point. Concentration, if the concentration of the mother liquor is reduced in order to control the temperature of the crystallization point, the process yield will be greatly reduced
Although the simple control of cooling rate and stirring rate has certain influence on the temperature of the crystallization point, it requires high equipment, and the adjustable range is small, and has little effect on crystal habit and particle size distribution, and does not change the crystal form of glycine.

Method used

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  • Method for controlling temperature of glycine cooling crystallization crystal point

Examples

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Effect test

Embodiment 1

[0025] Weigh glycine and deionized water with a mass ratio of 1:2, place them in a crystallizer, raise the temperature to 80°C, keep constant temperature and stir thoroughly, after glycine is completely dissolved, add 1-(4-sulfopropyl ) butyl-pyridine bisulfate, after it is completely dissolved, set the stirring speed to 200r / min, start cooling at a cooling rate of 15°C / min, and measure the crystal point temperature to be 46.5°C.

Embodiment 2

[0027] Weigh glycine and deionized water with a mass ratio of 1:2, place them in a crystallizer, raise the temperature to 80°C, keep the temperature constant and stir thoroughly, after the glycine is completely dissolved, add 0.5% of the solute mass of alkyl glycoside, and wait for it to completely dissolve Finally, the stirring speed was set to 400r / min, and the temperature was lowered at a cooling rate of 3°C / min, and the temperature of the crystal point was measured to be 52.3°C.

Embodiment 3

[0029] Weigh glycine and deionized water with a mass ratio of 1:2, place them in a crystallizer, raise the temperature to 80°C, keep the temperature constant and stir thoroughly, after the glycine is completely dissolved, add 0.5% of the solute mass of alkyl glycoside, and wait for it to completely dissolve Finally, the stirring speed was set to 800r / min, and the temperature was lowered at a cooling rate of 3°C / min, and the crystal point temperature was measured to be 60.3°C.

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Abstract

The invention belongs to the technical field of chemical crystallization and particularly relates to a method for controlling the temperature of a glycine cooling crystallization crystal point. The method specifically includes the steps that glycine and deionized water are added into a crystallizer according to a certain proportion, a proper additive is added after the materials are completely dissolved, after the additive is completely dissolved, temperature-controlled cooling and crystallization are conducted at a certain stirring speed and a certain cooling speed, and the temperature of the glycine crystal point is observed and recorded. The method for controlling the temperature of the glycine cooling crystallization crystal point can effectively control the supersaturation degree of a glycine solution and control the temperature of the glycine crystal point, and accordingly provides bases for optimizing the glycine crystallization technology.

Description

technical field [0001] The invention belongs to the technical field of chemical crystallization, and in particular relates to a method for regulating the crystallization point temperature of glycine cooling crystallization. Background technique [0002] Glycine (Glycine, CAS NO.56-40-6), also known as aminoacetic acid or tyrosine, the molecular formula is C 2 h 5 NO 2 , with a relative molecular mass of 75.07, is the simplest amino acid in structure. Solid glycine is white crystal or off-white crystalline powder, odorless, non-toxic, relative density 1.607, melting point 232-236°C (decomposition), easily soluble in water, very difficult to dissolve in ethanol, almost insoluble in acetone, ether, Slightly soluble in pyridine, reacts with hydrochloric acid to generate hydrochloride. Its molecular structural formula is as follows: [0003] [0004] Glycine is known to have three crystal forms of α, β, and γ, among which the γ-crystal form is the most stable, the α-cryst...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N25/12
CPCG01N25/12
Inventor 刘宝树孙华王禄
Owner HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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