Microfluidic chip and manufacturing method for transmission terahertz time-domain spectroscopy system

Abstract

The invention discloses a microfluidic chip used for a transmissive terahertz time-domain spectroscopy system and a manufacturing method thereof. The microfluidic chip provided by the invention is composed of a disc-shaped cover sheet, a clamping sheet and a substrate which are in fixedly-connected arrangement from top to bottom, wherein a to-be-measured liquid enters a detection area through a liquid inlet channel arranged on the cover sheet and a liquid inlet arranged on the clamping sheet, is measured by terahertz beams which vertically penetrate through the detection area of the microfluidic chip, and finally flows out through a liquid outlet and a liquid outlet channel arranged on the cover sheet. The manufacturing method for the microfluidic chip is simple, has high manufacturing efficiency and low processing cost, and does not relate to precision processing in the process of bonding; and the chip manufactured by using the manufacturing method for the microfluidic chip provided by the invention has the advantages of uniform and even thickness, more stable quality and convenient assembly and disassembly.

Description

technical field [0001] The invention relates to the technical field of terahertz time-domain spectroscopy measurement of liquid samples, in particular to a microfluidic chip and a manufacturing method for a transmission-type terahertz time-domain spectroscopy system. Background technique [0002] In recent years, with the rapid development of terahertz technology, it has been widely used in many fields. The collective vibrational modes of many biomolecules and the vibrational modes between molecules are in the terahertz frequency range, so the use of terahertz spectroscopy for label-free, loss-free, and ion-free sensing of biology and chemistry has attracted extensive attention. Most of the biomolecules exist in the water environment, and the interaction between water and biomolecules also involves many biological phenomena, so the study of biochemical sensing in the solution state is more suitable for the needs. However, the strong absorption of water to terahertz is a maj...

AI Technical Summary

Problems solved by technology

Among them, laser ablation and LIGA technology are used to process microfluidic chips made of materials such as glass and quartz. Although glass has excellent optical and electrical properties, it has disadvantages such as high processing cost and low bond yield.

The hot pressing method has disadvantages such as relatively low production efficiency and unstable chip quality.

The injection molding method is produced by making metal molds. One mold can produce a large number of chips, but it is prone to incomplete replication of microchannels, and making a large number of chips of different shapes requires multiple molds, which is more troublesome to operate.

Images