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Ultra-high performance liquid chromatography-quadrupole electrostatic field orbital ion trap mass spectrometry screening method for plasticizer in milk and dairy products

An ultra-high performance liquid phase and ion trap mass spectrometer technology is applied in the field of ultra-high performance liquid chromatography-quadrupole electrostatic field orbital ion trap mass spectrometry screening, and can solve the problems of less high-throughput, complicated pretreatment operations, and high equipment cost , to achieve the effect of high quantitative ability, fast positive and negative switching scanning mode, and low operating cost

Inactive Publication Date: 2017-03-22
SHAANXI UNIV OF SCI & TECH
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  • Description
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  • Application Information

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Problems solved by technology

At present, there are few high-throughput and rapid detection methods for exogenous risk substances in milk and dairy products, the pretreatment is complicated, the cost of materials and equipment is high, and it is limited to the rapid detection of several or one type of compounds

Method used

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  • Ultra-high performance liquid chromatography-quadrupole electrostatic field orbital ion trap mass spectrometry screening method for plasticizer in milk and dairy products
  • Ultra-high performance liquid chromatography-quadrupole electrostatic field orbital ion trap mass spectrometry screening method for plasticizer in milk and dairy products
  • Ultra-high performance liquid chromatography-quadrupole electrostatic field orbital ion trap mass spectrometry screening method for plasticizer in milk and dairy products

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Embodiment Construction

[0036] The invention provides an ultra-high performance liquid chromatography-quadrupole electrostatic field orbital ion trap mass spectrometry screening method for plasticizers in milk and dairy products, which is characterized in that the equipment used in the method includes ultra-high performance liquid chromatography - Quadrupole electrostatic field orbital ion trap mass spectrometer. Include the following steps:

[0037]First, prepare matrix solution and standard solution; use the optimized QuEChERS method to extract and clean up milk and dairy product samples;

[0038] Secondly, ultra-high performance liquid chromatography-quadrupole electrostatic field orbit ion trap mass spectrometry (Q-Orbitrap) was used for screening, using electrospray ionization source (ESI) and full scan / data dependent acquisition (Full MS / dd-MS 2 , full scan / variable data-independent acquisition (Full MS / vDIA), full scan / full ion fragmentation acquisition (Full MS / AIF) three scan modes to obtai...

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Abstract

The invention discloses an ultra-high performance liquid chromatography-quadrupole electrostatic field orbital ion trap mass spectrometry screening method for a plasticizer in milk and dairy products, belonging to the technical field of food safety detection. The method comprises the following steps: performing pretreatment of a sample by an optimized QuEChERS method; screening with ultra-high performance liquid chromatography-quadrupole electrostatic field orbital ion trap mass spectrometry; adopting full-scanning / data-dependent collection, full-scanning / varying data-independent collection and full-scanning / full-ion fragmentation collection scanning modes, and selecting a positive ion mode for scanning to obtain complete first-order and second-order spectra; treating the first-order and second-order spectra by use of Exact Finder 2.5 software to extract the compound information; and comparing the information in the established spectrum library with the screening result of the detected object to determine the composition of the plasticizer in milk and dairy products. In the invention, the adopted mass spectrometer has the main advantages of high resolution, accurate qualification and quantification results, high sensitivity, high mass precision and the like and can be used for analyzing a complicated matrix. The invention provides a fast and accurate analysis means for normal daily monitoring of exogenous risk materials in food.

Description

[0001] 【Technical field】 [0002] The invention belongs to the technical field of food safety detection, in particular to an ultra-high performance liquid chromatography-quadrupole electrostatic field orbital ion trap mass spectrometry screening method for plasticizers in milk and dairy products. [0003] 【Background technique】 [0004] Milk and dairy products include: liquid milk; milk fat; condensed milk; milk powder; cheese; other dairy products. Because of its wide variety and rich nutrition, it is loved by people. With the improvement of living standards, people pay more and more attention to the safety of milk and dairy products. Plasticizer is an exogenous substance that enhances the flexibility and ease of processing in plastic processing, and is legally used in industrial production. The plasticizers in milk and dairy products mainly come from the migration of plasticizers in packaging materials. Most of the packaging materials are high molecular polymers. During the...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/72
CPCG01N30/02G01N30/7266
Inventor 贾玮张焱茜
Owner SHAANXI UNIV OF SCI & TECH
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