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Preparation method of high-strength bone cement containing hydroxyapatite modified through gluconic acid

A technology of hydroxyapatite and gluconic acid, which is applied in the fields of pharmaceutical formula, medical science, prosthesis, etc., can solve the problem of low compressive strength, achieve improved mechanical properties, good biocompatibility and osteoconductivity, biological High safety effect

Active Publication Date: 2017-04-05
NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Japanese scholar Mamoru Aizawa proposed a hydroxyapatite bone cement surface-modified by phytic acid solution in the patent publication No. JP2005-95346A, and its powder is hydroxyapatite powder modified by phytic acid solution surface , the liquid phase is deionized water, the curing process basically does not change the pH value, but its compressive strength is not high, only 6.8MPA
Afterwards, in publication numbers JP2008-200476A, JP2009-178225A, US2010 / 0132593A1, and JP2012-130672, he optimized the particle size of the powder, the preparation process, and added polysaccharide or phytic acid to the curing solution to improve the compressive strength of the bone cement. It reaches 36MPa, which is between cancellous bone and cortical bone, but it can only be used in non-weight-bearing parts clinically

Method used

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  • Preparation method of high-strength bone cement containing hydroxyapatite modified through gluconic acid
  • Preparation method of high-strength bone cement containing hydroxyapatite modified through gluconic acid
  • Preparation method of high-strength bone cement containing hydroxyapatite modified through gluconic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Step 1: Preparation of solid phase powder:

[0032] (1) Take by weighing 10g hydroxyapatite powder;

[0033] (2) configure 50ml of 0.5% gluconic acid solution to adjust its pH value to about 7.3 with 0.5mol / L NaOH solution;

[0034] (3) Put the two in a ball mill jar, and use a planetary ball mill to perform ball milling on the powder for 2 hours while modifying at room temperature, wherein the mass ratio of gluconic acid to hydroxyapatite is 0.025;

[0035] (4) Separating balls and liquid after ball milling to obtain modified mixed slurry;

[0036] (5) Vacuum freeze-dry the modified mixed slurry, and collect the hydroxyapatite powder surface-modified with 0.5% gluconic acid solution after ball milling for 2 hours.

[0037] Step 2: Bone cement preparation:

[0038] (1) preparation of solidified solution: the solidified solution is a 20% gluconic acid aqueous solution with a mass concentration, weighs 4g of gluconic acid granules, and dissolves in 16g of distilled wat...

Embodiment 2

[0053] Step 1: Preparation of solid phase powder:

[0054] (1) Take by weighing 10g hydroxyapatite powder;

[0055] (2) configuration is 0.1% gluconic acid solution with 0.5mol / L NaOH solution to adjust its pH value to 50ml concentration of about 7.3;

[0056](3) Place the two in a ball mill jar, and use a planetary ball mill to perform ball milling on the powder at room temperature and simultaneously modify it for 4 hours, wherein the mass ratio of gluconic acid to hydroxyapatite is 0.005;

[0057] (4) Separating balls and liquid after ball milling to obtain ball mill slurry;

[0058] (5) Perform vacuum freeze-drying on the modified mixed slurry, and collect the hydroxyapatite powder surface-modified by 0.1% gluconic acid solution after ball milling for 4 hours.

[0059] Step 2: Bone cement preparation:

[0060] (1) preparation of solidified solution: the solidified solution is a 20% gluconic acid aqueous solution with a mass concentration, weighs 4g of gluconic acid granu...

Embodiment 3

[0069] Step 1: The preparation of the solid phase powder is the same as in Example 1, and the hydroxyapatite powder surface-modified by 0.5% gluconic acid solution after ball milling for 2 hours is obtained.

[0070] Step 2: Bone cement preparation:

[0071] (1) Preparation of solidified solution: the solidified solution is a 10% gluconic acid aqueous solution, weighed 2g of gluconic acid particles, dissolved in 18g of distilled water, to obtain final product;

[0072] (2) According to the solid-liquid mass ratio of 1:0.35, weigh a certain amount of solid-phase powder and 10% gluconic acid aqueous solution, and quickly mix them uniformly to obtain high-strength gluconic acid-modified hydroxyapatite bone cement.

[0073] Compressive strength test:

[0074] The operation steps are the same as in Example 1, and the average compressive strength of the bone cement compression sample is 60.5 MPa.

[0075] pH test:

[0076] The operation steps are the same as those in Example 1, a...

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Abstract

The invention relates to a preparation method of high-strength bone cement containing hydroxyapatite modified through gluconic acid. The method includes the steps that the hydroxyapatite subjected to surface modification through the gluconic acid is used as solid-phase powder, distilled water or a low-concentration gluconic acid solution is used as solidification liquid, the solid-phase powder and the solidification liquid are blended, and then the high-strength bone cement containing the hydroxyapatite modified through the gluconic acid is obtained. The preparation method of the bone cement is easy to operate, the obtained bone cement is good in biocompatibility and osteoconduction and high in compressive strength which can reach 78 MPa maximally and is higher than compressive strength of current bone cement prepared from single-phase hydroxyapatite serving as solid-phase powder. Meanwhile, the defects that heat release amount is large in the solidification process of first-generation polymethyl methacrylate (PMMA) bone cement, and the pH value changes in the solidification process of second-generation calcium phosphate bone cement (CPC) and consequently tissue inflammation occurs are overcome. The solidification process of the high-strength bone cement does not depend on the acid-base reaction, the pH value of surrounding body fluid is neutral, the heat release amount is extremely low, and the excellent comprehensive properties of the high-strength bone cement meet the clinical requirements. By means of the preparation method of the high-strength bone cement containing the hydroxyapatite modified through the gluconic acid, new path for improving the properties of the hydroxyapatite bone cement is developed, and the application range of the gluconic acid is widened.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a preparation method of high-strength gluconic acid modified hydroxyapatite bone cement. Background technique [0002] Bone cement, as a bone tissue repair and replacement material, has broad prospects in orthopedic surgery, dentistry, and plastic surgery. It is used for filling and fixing bone defects and as a slow-release drug carrier. [0003] Currently, there are two main types of bone cement materials used clinically: acrylic bone cement represented by the first-generation polymethyl methacrylate (PMMA) and second-generation calcium phosphate bone cement (CPC). PMMA bone cement has good mechanical properties and high strength, which are its outstanding features, but due to the release of a large amount of heat and some residual monomers during the curing reaction, it will cause a series of complications in patients, which is limited in clinical application; and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/50A61L27/12
CPCA61L27/12A61L27/50A61L2400/18A61L2430/02
Inventor 汪涛杨心王阳阳钱海
Owner NANJING UNIV OF AERONAUTICS & ASTRONAUTICS