Unlock instant, AI-driven research and patent intelligence for your innovation.

Preparation method of composite absorbable protein-type non-sticky foam dressing

A compound protein and foam technology, applied in pharmaceutical formulations, pharmaceutical science, drug delivery, etc., can solve the problems of cells easily growing into the pores of the dressing, loss of integrity, fluid leakage, etc., to achieve rapid and exudate absorption capacity, The effect of good integrity and high water absorption

Inactive Publication Date: 2017-04-26
唐林元
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem mainly solved by the present invention: aiming at the defect that the existing foam dressing is easily damaged when exposed to corrosive fluid, easily swells and loses integrity, resulting in fluid leakage, and cells are easy to grow into the pores of the dressing, resulting in wound adhesion, providing A kind of amino acid and polypeptide structure that can be easily absorbed by the human body by decomposing human hair protein, which is loaded into the foam dressing. During the use of the dressing, the human body can be fully absorbed while accelerating the healing of the human body without secondary stickiness. phenomenon, the present invention first uses black human hair as a raw material to prepare human hair keratin powder, then crushes corn stalks, washes and dries them with hydrogen peroxide solution, collects the obtained dried fibers, heats and filters them with keratinase, acrylic acid, etc., and then collects the filtered After the cake is dried and milled, it is mixed with polyether polyol 330N, human hair keratin powder, etc., put into a mold for aging treatment, and finally released from the mold to obtain an absorbable composite protein-type non-stick foam dressing. The protein-type non-sticky foam dressing can form a moist environment in the surface area of ​​the wound, which is beneficial to promote the growth of wound granulation tissue and promote wound healing. At the same time, the foam dressing of the present invention has good integrity after swelling, and can effectively prevent fluid leakage and facilitate dressing replacement. Convenient, not easy to remain on the wound or adhesive wound, has a wide range of application prospects

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0017] First, select black human hair, wash it and dry it naturally, crush it with a jet mill and sieve it, collect 75 mesh human hair powder, mix the human hair powder with 10% sodium hydroxide in mass fraction according to the mass ratio of 1:20 The solution was stirred and mixed, heated in a water bath at 75°C for 2 hours, then filtered and the filtrate was collected, adjusted to pH 7.0 with 1 mol / L hydrochloric acid, left to settle for 3 hours, then filtered and the filter cake was collected, vacuum freeze-dried, and ground to prepare human hair Keratin powder, for later use; then collect corn stalks, wash them and dry them at 75°C for 6 hours, then grind them and pass them through a 90-mesh sieve to collect corn stalk powder, then mix the corn stalks with a mass ratio of 1:20 Stir and mix the powder with 10% hydrogen peroxide solution by mass, heat in a water bath at 45°C for 2h, then let it stand and cool to room temperature, wash with deionization three times, and dry at...

example 2

[0020]First, choose black human hair, wash it and dry it naturally, crush it with a jet mill and sieve it, collect 78 mesh human hair powder, mix the human hair powder with 10% sodium hydroxide in mass fraction according to the mass ratio of 1:20 The solution was stirred and mixed, heated in a water bath at 78°C for 2 hours, then filtered and the filtrate was collected, adjusted to pH 7.0 with 1 mol / L hydrochloric acid, left to settle for 4 hours, then filtered and the filter cake was collected, vacuum freeze-dried, and ground to prepare human hair Keratin powder, for later use; then collect corn stalks, wash them and dry them at 78°C for 7 hours, then grind them and pass through a 95-mesh sieve to collect corn stalk powder, then mix the corn stalks with a mass ratio of 1:20 The powder was stirred and mixed with 10% hydrogen peroxide solution in parts by mass, heated in a water bath at 48°C for 2h, then left to cool to room temperature, washed with deionization for 4 times, and...

example 3

[0023] First, select black human hair, wash it and dry it naturally, crush it with a jet mill and sieve it, collect 80 mesh human hair powder, mix the human hair powder with 10% sodium hydroxide in mass fraction according to the mass ratio of 1:20 The solution was stirred and mixed, heated in a water bath at 80°C for 3 hours, then filtered and the filtrate was collected, adjusted to pH 7.0 with 1 mol / L hydrochloric acid, left to settle for 5 hours, then filtered and the filter cake was collected, vacuum freeze-dried, and ground to prepare human hair Keratin powder, for later use; then collect corn stalks, wash them and dry them at 80°C for 8 hours, then grind them and pass them through a 100-mesh sieve to collect corn stalk powder, then mix the corn stalks with a mass ratio of 1:20 Stir and mix the powder with 10% hydrogen peroxide solution by mass, heat in a water bath at 50°C for 3h, then let it stand and cool to room temperature, wash with deionization for 5 times, and dry a...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
tensile strengthaaaaaaaaaa
water absorptionaaaaaaaaaa
tensile strengthaaaaaaaaaa
Login to View More

Abstract

The invention discloses a preparation method of a composite absorbable protein-type non-sticky foam dressing, and belongs to the technical field of preparation of medical dressings. The preparation method comprises the following steps: firstly, preparing human hair keratin powder from black human hair; then, crushing corn stalks and washing and drying the crushed corn stalks with a hydrogen peroxide solution, and heating and filtering collected dry fibers with keratinase, acrylic acid and the like; then, collecting a filter cake and drying and milling the filter cake, mixing the processed filter cake with polyether polyol 330N, the human hair keratin powder and the like, and curing an obtained mixture in a die, and finally, conducting demoulding so as to obtain the composite absorbable protein-type non-sticky foam dressing. The composite absorbable protein-type non-sticky foam dressing provided by the invention can form a wet environment in the surface area of a wound surface, so as to bring about benefits for promoting the growth of granulation tissues of the wound surface and to accelerate healing of the wound surfaces; meanwhile, the foam dressing provided by the invention is good in integrity after getting swollen and is the foam dressing is capable of effectively preventing fluid seepage; and the dressing is convenient to change and cannot remain in the wound surfaces or cause adhesion of wounds easily; therefore, the dressing has a broad application prospect.

Description

technical field [0001] The invention discloses a preparation method of an absorbable composite protein type non-stick foam dressing, which belongs to the technical field of preparation of medical dressings. Background technique [0002] The skin has important functions such as protecting the body, regulating body temperature, preventing bacterial infection, perception, and secretion. If various traumas or wounds, burns, and sores occur, it will lose its function. If it loses its function, it will bring pain to the patient until the wound is completely healed. If it is seriously injured, it will be life-threatening, and after the treatment is over, it will cause a second pain due to severe scars . [0003] Foam-type medical dressings are suitable for wound granulation, can absorb excess wound exudate, and can block external foreign bodies and some bacteria, protect exposed nerve endings, and relieve pain. In addition, because the foam dressing keeps moist, it avoids the exc...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0085A61L26/0014A61L26/0047A61L26/0057A61L26/009A61L2400/04C08L89/00C08L33/02
Inventor 唐林元韩彪薛国忠
Owner 唐林元