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High-valence silver antibacterial agent and preparation method thereof

An antibacterial agent and high-priced silver technology, which is applied in the field of preparation of high-priced silver antibacterial agents, can solve the problems of high-priced silver instability, poor stability, and limited ligands, and achieve high thermodynamic stability, good washability, and low equipment requirements Effect

Active Publication Date: 2017-04-26
FUZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But high-priced silver is unstable, especially Ag 3+ worse stability
For example, U.S. Patent No. 20070042052 discloses an Ag-containing 2+ antibacterial agent, but this Ag-containing 2+ Antimicrobial agents only exist stably in concentrated acid environments, so preservation and transportation are extremely difficult
Can interact with Ag 3+ The ligands for complexation are extremely limited. At present, only corrole, porphyrin, iminoxime, and biguanide can be combined with Ag 3+ complexes, but corroles, porphyrins, iminoximes and Ag 3+ The complexes formed are less stable to photos and will decompose in water
Patent 201080046629.X synthesized silver-chlorhexidine complex in water / AOT / heptane, but since chlorhexidine can only be dissolved in acidic environment, a certain amount of acid and neutralizer needs to be consumed in the preparation process

Method used

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  • High-valence silver antibacterial agent and preparation method thereof
  • High-valence silver antibacterial agent and preparation method thereof
  • High-valence silver antibacterial agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 Nanoscale Ag ( )-PHMB complex synthesis

[0033] (1) Preparation of inverse microemulsion

[0034] Take 1.2 g of bis(2-ethylhexyl) sodium sulfosuccinate (AOT), dissolve it in 18 g of heptane at room temperature and stir until transparent;

[0035] (2) Add 255 μL of water and 256 μL of 5 g / L PHMB aqueous solution with a viscosity average molecular weight of 2133 to step (1), and stir until clarified under magnetic force;

[0036] (3) Add 0.04 mol / L AgNO to step (2) 3 73 μL and stir until clear and colorless;

[0037] (4) Add 0.04 mol / L Na to step (3) 2 S 2 o 8 146 μL, add dropwise NaOH solution of PH=14 to adjust the pH between 9-11 and stir for 22 h until the inverse microemulsion turns light orange-brown. A small amount of ethanol was added for centrifugation, washed with ethanol and deionized water, and dried to obtain nanoscale Ag ( )-PHMB complexes.

Embodiment 2

[0038] Embodiment 2 nanoscale Ag ( )-PHMB complex synthesis

[0039] (1) Preparation of inverse microemulsion

[0040] Dissolve 1.4 g of ethylene bis(dodecyldimethyl)ammonium chloride (cationic gemini surfactant) in 18 g of heptane and stir until transparent.

[0041] (2) Add 380 μL of 5 g / L PHMB aqueous solution with a viscosity average molecular weight of 3245 to step (1), and stir until clarified under magnetic force.

[0042] (3) Add 0.04 mol / L AgNO to step (2) 3 73 μL and stir until clear and colorless.

[0043] (4) Add 0.04 mol / L of K to step (3) 2 S 2 o 8 220 μL, dropwise add NaOH solution of PH=14 to adjust the pH between 9-11, and stir for 18 h until the inverse microemulsion turns light orange-brown. A small amount of ethanol was added for centrifugation, washed with ethanol and deionized water, and dried to obtain nanoscale Ag ( )-PHMB complexes.

Embodiment 3

[0044] Example 3 Nanoscale Ag ( )-PHMB complex synthesis

[0045] (1) Preparation of inverse microemulsion

[0046] Dissolve 1.5 g of 5,5'-dinonyl-2,2'-(α,ω-alkylenedioxy)sodium dibenzenesulfonate (anionic gemini surfactant) in 18 g of heptane and stir until transparent.

[0047] (2) Add 510 μL of 10 g / L PHMB aqueous solution with a viscosity average molecular weight of 5248 to step (1) and stir until clear.

[0048] (3) Add 0.08 mol / L AgNO to step (2) 3 73 μL and stir until clear and colorless.

[0049] (4) Add 0.08 mol / L of K to step (3) 2 S 2 o 8 220 μL, add dropwise NaOH with pH=14

[0050] Adjust the pH of the solution between 9-11, and stir for 18 hours until the inverse microemulsion turns light orange-brown. Add a small amount of ethanol to centrifuge, wash and dry with ethanol and deionized water to obtain nanoscale Ag ( )-PHMB complexes.

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Abstract

The invention belongs to the field of fine chemical engineering, and particularly relates to a high-valence silver antibacterial agent and a preparation method thereof. The high-valence silver antibacterial agent is a silver-polyhexamethylene biguanidine complex with the electric potential zeta larger than 0. A metal part of the silver-polyhexamethylene biguanidine complex is Ag3+, and the antibacterial property of the complex is 200 times that of Ag+. A biological acceptable part is polyhexamethylene biguanidine (PHMB), compared with other guanidines with small molecular weights, the antibacterial property is good, the advantages are more obvious because of the synergistic antibacterial effect of PHMB and other antibiotics, and toxicity to cells and tissue of human bodies is smaller. The nanoscale or micron-size Ag(III)-PHMB complex high in antibacterial activity is prepared by means of reversed-phase microemulsion or the aqueous solution environment. On one hand, the Ag(III)-PHMB complex can reduce toxicity, and on the other hand, the metal part and the biological acceptable part achieve the synergistic antibacterial effect so that the antibacterial property of the antibacterial agent can be effectively improved. The antibacterial agent has a great significance in treatment of human epidermis infection.

Description

technical field [0001] The invention belongs to the field of fine chemicals, and in particular relates to a preparation method of a high-priced silver antibacterial agent. Background technique [0002] Harmful bacteria and fungi in nature are one of the main infectious disease pathogens in human society. The black death, scarlet fever, anthrax, etc. that have been raging in the past, and the current food poisoning, bacterial skin diseases, and pneumonia are all caused by Yersinia pestis, chain coccus, Bacillus anthracis, Escherichia coli, staphylococcus, pneumococcus and other pathogenic bacteria. [0003] Since ancient times, people have used silverware to prevent corruption. Modern research has found that the antibacterial mechanism of silver and silver ions is as follows: On the one hand, the S-H interaction between silver and proteins and enzymes affects the normal physiological activities of cells; on the other hand, silver ions are adsorbed on the surface of the cell ...

Claims

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Application Information

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IPC IPC(8): C08G73/00A01N55/00A61K31/785A01P1/00A61P31/04D06M15/37D06M101/06
CPCA01N55/00A61K31/785C08G73/00D06M15/37D06M16/00D06M2101/06
Inventor 侯琳熙赵鑫钰陈雷光朱贤锋
Owner FUZHOU UNIVERSITY
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