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3D-printed bone repair scaffold containing multistage channels and manufacturing method thereof

A 3D printing and manufacturing method technology, applied in the field of 3D printing, can solve the problem of not being able to print large-size personalized scaffold materials, and achieve the effect of being conducive to vascularization and good biocompatibility

Inactive Publication Date: 2017-05-03
广州邦菲医疗器械科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] ③Using fiber deposition technology can be used for personalized additive manufacturing of tricalcium phosphate materials, but due to reasons such as adhesives, it is currently impossible to print large-scale personalized (such as jaw repair brackets) bracket materials

Method used

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  • 3D-printed bone repair scaffold containing multistage channels and manufacturing method thereof
  • 3D-printed bone repair scaffold containing multistage channels and manufacturing method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment

[0025] A method for manufacturing a 3D-printed bone repair bracket containing multi-level channels, comprising the steps of:

[0026] (1) Stent design: first obtain the imaging data of the defect repair site and the healthy side, and design the morphology of the stent at the defect site by mirror image after 3D reconstruction; design multi-level vascular channels according to the vessel morphology and shape of the defect site, and the diameter distribution is as follows: The primary channel is 2mm, the secondary channel is 1.5mm, and the tertiary channel is 1mm, and the distance between adjacent pipes is 4mm-5mm;

[0027] (2) Ink preparation: First, after calcining the original TCP powder at 1300°C, grind and screen the powder material with a particle size of 100 microns; use a laser scattering instrument with sample dispersion detection to determine the particle size distribution of the sample powder; secondly , dissolved in distilled water C dispersant, gradually add the s...

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Abstract

The invention discloses a 3D-printed bone repair scaffold containing multistage channels and a manufacturing method thereof, belonging to the technical field of 3D printing. According to the invention, CAD software is employed for designing the structure of the scaffold; then printing ink is prepared; and an automatic slip-casting machine is used for directly printing a customized scaffold material. An inorganic material tricalcium phosphate similar to the component of bone tissue is used as a main component, so good biocompatibility is obtained, and customized manufacturing is realized. Meanwhile, pre-structured blood-vessel-bundle multistage channels facilitate proliferation and migration of peripheral vascular buds and are beneficial for vascularization of the scaffold material.

Description

technical field [0001] The invention belongs to the technical field of 3D printing, in particular to a 3D printed bone repair bracket containing multi-level channels and a manufacturing method thereof. Background technique [0002] Trauma, tumor, inflammation, etc. often lead to bone tissue damage in the maxillofacial region or other parts of the body, and cause acute and chronic functional impairment, etc., seriously affecting people's quality of life and mental health. The repair and reconstruction of these bone defects has always been a difficult problem for clinicians. At present, the blocky heterogeneous bone used for bone defect repair mainly includes: [0003] ①The traditional manufacturing process-foaming method is used to prepare the molding, and the internal pore-forming agent is removed by high-temperature sintering in the later stage to form a porous scaffold material. The shape control of the scaffold material prepared by this method depends on the correspondi...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/56A61L27/50B33Y10/00B33Y80/00
CPCA61L27/12A61L27/50A61L27/56A61L2430/02B33Y10/00B33Y80/00
Inventor 周友波佩德罗.米兰达.冈萨雷斯周苗李树祎吴刚
Owner 广州邦菲医疗器械科技有限公司