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Yeast fructose composition affecting purine metabolism

A composition and fructose technology, applied in the direction of animal feed, animal feed, additional food elements, etc., can solve the problems of accelerated AMP dephosphorylation, unstable high uric acid level, lack of phosphoric acid, etc., to avoid animal damage and rational composition of ingredients. , the effect of uniform active ingredients

Active Publication Date: 2017-05-10
营膳健康科技(青岛)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the massive phosphorylation of fructose leads to a shortage of phosphate, which accelerates a series of steps in the dephosphorylation of AMP
Studies have shown that 10% fructose water can increase the blood uric acid level in rats, but the high uric acid level formed is extremely unstable

Method used

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  • Yeast fructose composition affecting purine metabolism
  • Yeast fructose composition affecting purine metabolism
  • Yeast fructose composition affecting purine metabolism

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The composition involved in this embodiment is a high yeast feed with a mass percentage of 20% and a fructose aqueous solution with a mass percentage concentration of 10%.

[0018] The high-yeast feed with a mass percentage of 20% involved in this example is prepared in the following steps: pulverize the commercially available common granular feed for rats into a powder with a particle size of 0.1 to 1 mm, and then uniformly add a weight percentage of It is 20% yeast extract, and then the feed is remade into spherical particles with a diameter of 2-6mm; the involved mass percent concentration is 10% fructose aqueous solution, which is the fructose aqueous solution configured by dissolving D-fructose in tap water.

[0019] The formula of the common granular feed for rats involved in this embodiment is: 20.50% crude protein, 4.62% crude fat, 4.35% crude fiber, 6.2% crude ash, 1.23% calcium, 0.91% phosphorus, energy It is 345kcal / kg; Fructose and yeast extract wherein all ...

Embodiment 2

[0021] Embodiment 2: In this embodiment, the steps of specifically constructing an animal model of hyperuricemia include:

[0022] (1) Selection of animal samples: 8-week-old male clean-grade Wistar rats with a body mass of (200±20) g were purchased from Shandong Lukang Pharmaceutical Co., Ltd. and fed in the SPF animal breeding room of Qingdao University School of Medicine. Before the start of the experiment, normal rat pellet feed was used to feed adaptively for 1 week. During the experiment, the rats’ body surface characteristics were observed, whether there were abnormal changes in behavioral activities, and the abnormal rats were isolated. Finally, the body surface characteristics and 40 Wistar rats with no abnormal behaviors; the environment for adaptive feeding is: temperature: 20-24°C, relative humidity: 50%-70%, light rhythm: 12D: 12L, working illuminance: 150-300lx, airflow , wind speed 0.1~0.2m / s, noise≤60dB; The feed of described adaptive feeding is common rat pell...

Embodiment 3

[0027]In this example, the animal intervention of Example 2 was used for the experiment: at 8 o'clock in the morning after the experiments were carried out for 2, 4, 6 and 8 weeks respectively, the rats were fasted for 12 hours and then cut their tails to take 1.0-1.5 ml of blood, and left to stand at room temperature for coagulation. Centrifuge at 3000r / min for 5min, take 300μl of serum, and measure serum uric acid (SUA), serum urea nitrogen (BUN) and serum creatinine (SCr) with an automatic biochemical analyzer; the results are shown in Table 1. After 2w of the experiment, the yeast control group , yeast oxonate potassium group and yeast fructose group reached 262.66, 267.44 and 345.91 μmol / L respectively; compared with the blank control group, they all increased significantly (P0.05), and the yeast oxonate potassium group (465.25 μmol / L) and yeast fructose group (451.41μmol / L) compared with the blank control group, the SUA level was still significantly increased (P<0.05); w...

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Abstract

The present invention belongs to the technical field of medicine preparations and relates to a yeast fructose composition affecting purine metabolism. The active ingredients comprise a yeast extract and D-fructose; the active ingredients are mixed according to the mass ratio and the mixture is prepared into granules or solution by using conventional processes; wherein a high yeast feed is prepared by the following steps: a commercial granule feed for rats is crushed, then the yeast extract is added evenly into the feed, and finally the mixture is manufactured into the granules with original shapes and sizes; the fructose aqueous solution is prepared by the following steps: the D-fructose is dissolved in pure water and prepared into the fructose solution; wherein the commercial granule feed for the rats comprises crude proteins, crude fats, crude fibers, crude ash, calcium and phosphorus; the high yeast feed and the fructose aqueous solution are used as a package composition for a combined feeding of animals; the operation is easy to master and avoids animal damages caused by long-term gavage or injection; and the composition is scientific in formula, simple in preparation processes, even in effective ingredients, reasonable in ingredient matching, good in use effects, and easy in feeding.

Description

[0001] Technical field: [0002] The invention belongs to the technical field of drug preparation, and relates to a yeast fructose composition capable of affecting purine metabolism; its active ingredients include yeast extract and D-fructose, and the effective ingredients are mixed according to the mass ratio and prepared into granules or solutions by conventional techniques. [0003] Background technique: [0004] Serum uric acid is the final product of human purine metabolism, and its abnormal increase can cause hyperuricemia. Hyperuricemia is the pathogenic basis of gout, and it was reported that 18.8% of patients with hyperuricemia developed gout during the 5-year follow-up period. In recent years, epidemiological studies have shown that the prevalence of hyperuricemia and gout is increasing, and both diseases have become public health problems that need to be solved urgently. Due to the rapid economic development, the Chinese lifestyle has undergone great changes, and th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K50/50A23K10/18A23K20/163
Inventor 马爱国别凤仪张华琦孙永叶
Owner 营膳健康科技(青岛)有限公司
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