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Preparation method of gold/nitrogen-doped hollow carbon nanosphere core-shell material

A nitrogen-doped, hollow carbon technology, applied in the field of biomedical materials, can solve the problems of poor treatment effect, incurable cancer, toxic and side effects, etc., achieve good biocompatibility and photothermal stability, and improve photothermal conversion Efficiency, the effect of a simple design method

Inactive Publication Date: 2017-05-10
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although many treatments and treatments have been developed to treat cancer, the survival rate of cancer patients is still very low
Nowadays, the clinical methods of treating cancer are mainly through surgery, chemotherapy and radiotherapy. However, due to the metastatic and invasive nature of cancer, in the advanced stage of cancer, general surgery can no longer cure cancer. Chemotherapy and radiotherapy are more feasible methods
However, the specificity of chemotherapy and radiotherapy to tumor tissue is poor, which makes the treatment effect poor and has certain toxic and side effects.

Method used

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  • Preparation method of gold/nitrogen-doped hollow carbon nanosphere core-shell material
  • Preparation method of gold/nitrogen-doped hollow carbon nanosphere core-shell material
  • Preparation method of gold/nitrogen-doped hollow carbon nanosphere core-shell material

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Experimental program
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Effect test

Embodiment 1

[0035] (1) Preparation of PVP-modified gold sol: Take 30 mL of water in a 100 mL single-necked round-bottom flask and heat to boiling, add 150 mM HAuCl 4 100 μL of aqueous solution and 74 μL of 34 mM trisodium citrate aqueous solution were refluxed for 0.5 h at a stirring speed of 700 r / min. After the solution was cooled to room temperature, 5.86 mL of 1.28 mM PVP aqueous solution was added and stirred overnight.

[0036] Put the reacted solution in a centrifuge tube and centrifuge at 11800 r / min for 1 to 2 times, take out the supernatant with a dropper, and disperse the remaining solid-phase gold sol in 8 mL deionized water to obtain gold sol for later use.

[0037] (2) Au@SiO2 2 Preparation of spheres: Take 2 mL of gold sol and sonicate for 3 to 5 min at a power of 80 W, put 1 mL of ammonia water, 6 mL of deionized water, and 10 mL of ethanol into a 50 mL single-necked round-bottom flask. Stir at 700 r / min for 0.5 h. Finally, 0.5 mL TEOS was added, stirred at room temperatu...

Embodiment 2

[0041] (1) Preparation of PVP-modified gold sol: Take 30 mL of water in a 100 mL single-necked round-bottom flask and heat to boiling, add 150 mM HAuCl 4 100 μL of aqueous solution and 74 μL of 34 mM trisodium citrate aqueous solution were refluxed for 0.5 h at a stirring speed of 700 r / min. After the solution was cooled to room temperature, 5.86 mL of 1.28 mM PVP aqueous solution was added and stirred overnight.

[0042] Put the reacted solution in a centrifuge tube and centrifuge at 11800 r / min for 1-2 times, take out the supernatant with a dropper, and disperse the remaining solid-phase gold sol in 8 mL deionized water to obtain the gold sol for later use.

[0043] (2) Au@SiO2 2 Preparation of spheres: Take 2 mL of gold sol and sonicate for 3 to 5 min at a power of 80 W, put 1 mL of ammonia water, 6 mL of deionized water, and 10 mL of ethanol into a 50 mL single-necked round-bottom flask. Stir at 700 r / min for 0.5 h. Finally, 0.5 mL TEOS was added, stirred at room temper...

Embodiment 3

[0047] (1) Preparation of PVP-modified gold sol: Take 30 mL of water in a 100 mL single-necked round-bottom flask and heat to boiling, add 150 mM HAuCl 4 100 μL of aqueous solution and 74 μL of 34 mM trisodium citrate aqueous solution were refluxed for 0.5 h at a stirring speed of 600 r / min. After the solution was cooled to room temperature, 5.86 mL of 1.28 mM PVP aqueous solution was added and stirred overnight.

[0048] Put the reacted solution in a centrifuge tube and centrifuge at 11800 r / min for 1-2 times, take out the supernatant with a dropper, and disperse the remaining solid-phase gold sol in 8 mL deionized water to obtain the gold sol for later use.

[0049] (2) Au@SiO2 2 Preparation of spheres: Take 2 mL of gold sol and sonicate for 3 to 5 min at a power of 80 W, put 1 mL of ammonia water, 6 mL of deionized water, and 10 mL of ethanol into a 50 mL single-necked round-bottom flask. Stir at 600 r / min for 0.5 h. Finally, 0.5 mL TEOS was added, stirred at room temper...

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Abstract

The invention relates to a preparation method of a gold / nitrogen-doped hollow carbon nanosphere core-shell material, belonging to the field of biomedical materials. The preparation method comprises the steps of firstly, preparing gold sol by using a sol-gel method; secondly, coating the surfaces of gold particles with SiO2 by using an improved stober method, and then forming Au@SiO2@PDA spheres in a weak alkaline water-containing environment by means of auto polymerization of dopamine; finally, carrying out high-temperature calcination, and obtaining the gold / nitrogen-doped hollow carbon nanosphere core-shell material after NaOH is etched. The method is simple, mild and environment-friendly, and does not add additional toxicity; the prepared gold / nitrogen-doped hollow carbon nanosphere core-shell material has the particle size of about 165-175nm; as a near-infrared photothermal therapeutic agent for treating tumors, a product not only has good biocompatibility and light and heat stability, but also has the characteristic of having an internal hollow structure; after the gold / nitrogen-doped hollow carbon nanosphere core-shell material is used, the speed of particle exchange is accelerated, and the photothermal conversion efficiency is improved.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to the photothermal treatment technology of minimally invasive tumors. Background technique [0002] Cancer (malignant tumor) is an increasing threat to human health, and its incidence is increasing every year, and its mortality rate remains high. Although many treatments and treatments have been developed to treat cancer, the survival rate of cancer patients is still very low. Nowadays, the clinical methods of treating cancer are mainly through surgery, chemotherapy and radiotherapy. However, due to the metastatic and invasive nature of cancer, in the advanced stage of cancer, general surgery can no longer cure cancer, and chemotherapy and radiotherapy are more feasible methods. However, the specificity of chemotherapy and radiotherapy to tumor tissue is poor, which makes the treatment effect poor and has certain toxic and side effects. Therefore, improving the cure efficiency...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00B82Y5/00A61K9/50A61K47/34A61K47/04A61P35/00
CPCA61K9/501A61K9/5031A61K9/5073A61K41/0052B82Y5/00
Inventor 范磊徐祥东杨莉徐志龙郭荣
Owner YANGZHOU UNIV
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