Formula and preparation method of engineered bone scaffold

A technology of engineering bone and formula, applied in the field of medicine, can solve the problems of easy infection of defect lesions, large bone defect, harmful to the body, etc.

Active Publication Date: 2017-05-10
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Bone tissue engineering scaffold materials combined with growth factors or drugs can improve the bone repair effect of implanted scaffold materials, but in clinical cases, the bone defect to be repaired is often large, and infection is prone to occur around the defect lesion. Growth factors or drugs are difficult to achieve the desired effect, or even harmful to the body

Method used

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  • Formula and preparation method of engineered bone scaffold

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Effect test

Embodiment 1

[0024] 1. The formula of the engineering bone scaffold listed in this embodiment is made of the following raw materials: polyvinyl alcohol powder, deionized water, and biphasic calcium phosphate powder, and the degree of alcoholysis of the polyvinyl alcohol powder is 99+%. .

[0025] 2. The method for preparing the engineered bone scaffold according to claim 1, characterized in that: proceed as follows:

[0026] (1) Make up: first polyvinyl alcohol powder is dissolved in deionized water and is made into the polyvinyl alcohol colloid of 0.15g / ml;

[0027] (2) mixing: mixing polyvinyl alcohol colloid and biphasic calcium phosphate powder in (1);

[0028] (3) Stirring: Stir the compound in (2) evenly to obtain a mixed tissue of biphasic calcium phosphate and polyvinyl alcohol paste;

[0029] (4) Loading: load the three-dimensional file of the patient's bone defect model into the biomaterial printer;

[0030] (5) Printing: Pour the mixed tissue of biphasic calcium phosphate and...

Embodiment 2

[0039] 1. The formula of the engineering bone scaffold listed in this embodiment is made of the following raw materials: polyvinyl alcohol powder, deionized water, and biphasic calcium phosphate powder, and the degree of alcoholysis of the polyvinyl alcohol powder is 99+%. .

[0040] 2. The method for preparing the engineered bone scaffold according to claim 1, characterized in that: proceed as follows:

[0041] (1) Make up: first polyvinyl alcohol powder is dissolved in deionized water and is made into the polyvinyl alcohol colloid of 0.15g / ml;

[0042] (2) mixing: mixing polyvinyl alcohol colloid and biphasic calcium phosphate powder in (1);

[0043](3) Stirring: Stir the compound in (2) evenly to obtain a mixed tissue of biphasic calcium phosphate and polyvinyl alcohol paste;

[0044] (4) Loading: load the three-dimensional file of the patient's bone defect model into the biomaterial printer;

[0045] (5) Printing: Pour the mixed tissue of biphasic calcium phosphate and ...

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Abstract

The invention discloses a formula and a preparation method of an engineered bone scaffold. The formula comprises polyvinyl alcohol powder, deionized water and two-phase calcium phosphate. Firstly, 0.15 g / ml of polyvinyl alcohol colloid is prepared by dissolving polyvinyl alcohol in deionized water, then two-phase calcium phosphate-polyvinyl alcohol paste tissue is formed by compounding two-phase calcium phosphate and polyvinyl alcohol colloid, the paste as a raw material is printed by a biological material printer, and a two-phase calcium phosphate-polyvinyl alcohol tissue engineered bone scaffold material with inducing osteogenesis capacity is prepared. The bone tissue engineering scaffold can combine growth factors and medicines, has a slow release effect and has effective potential clinical use value.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a formula and a preparation method of an engineering bone support. Background technique [0002] Large-scale bone defect and nonunion are very common problems in medical work. It is common in trauma, tumor, infection, congenital or developmental diseases, etc. It has always been a worldwide problem in the field of orthopedics, and it has not been effectively solved so far. At present, the commonly used repair methods include autologous bone graft, allogeneic bone graft, artificial synthetic substitutes, etc., but these methods have limitations in the donor site, more complications and sequelae, antigenicity, biocompatibility, biological activity, biological Degradability, mechanical matching with the host bone, and service life have their own shortcomings, which limit their clinical application and make it difficult to achieve satisfactory results. The proposal, e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/58A61L27/54B33Y70/00B33Y80/00
CPCA61L27/46A61L27/54A61L27/58A61L2430/40B33Y70/00B33Y80/00C08L29/04
Inventor 宋岳毕龙曾庆丰林楷丰张帅帅刘斌何树裴国献
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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