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Application of Vaccarin in preparation of antihypertensive drugs

A flavonoid glycoside and anti-hypertensive technology of blancalicum, applied in application, drug combination, food science, etc., can solve problems such as accelerating the healing speed of open wounds

Inactive Publication Date: 2017-05-17
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Buliuxing mainly contains erythrine, triterpenoid saponins, flavonoid glycosides, lipids, cyclic peptides, fatty acids, and monosaccharides. Past laboratory studies have found that blancia glycosides can promote angiogenesis and accelerate open wound healing. The healing speed of anti-endothelial cell injury caused by high glucose and oxidative stress suggests that blaliculine glycosides may have cardiovascular protective effects, especially there is no report of blaliculine glycosides in the preparation of antihypertensive drugs role in

Method used

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  • Application of Vaccarin in preparation of antihypertensive drugs
  • Application of Vaccarin in preparation of antihypertensive drugs
  • Application of Vaccarin in preparation of antihypertensive drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] The making of embodiment 1 renovascular hypertension model

[0010] SD rats weighing 160-180 g were intraperitoneally anesthetized with pentobarbital sodium (60 mg·kg-1), and the depth of anesthesia was judged by pedal reflex. Under sterile surgical conditions, the right kidney and right renal artery were exposed along the retroperitoneal path through a longitudinal waist incision, and a U-shaped silver clip with an inner diameter of 0.2 mm was placed on the right renal artery to partially narrow the right renal artery, while the left kidney remained intact. Penicillin anti-infection (2K1C) was given after operation. The rats in the sham operation group (Sham) were operated the same as the rats with renal hypertension except that the U-shaped silver clip was not placed. In this study, the systolic arterial pressure (systolic arterial pressure, SBP)≧160mmHg in awake state was used as the standard of hypertension.

Embodiment 2

[0011] Example 2 Experimental Grouping and the Intervention of Buliuxing Flavonoid Glycosides

[0012] The rats were randomly divided into four groups:

[0013] (1) Rats in the sham operation group (Sham): normal control group, given normal diet and drinking water all the time.

[0014] (2) Renal hypertension-no administration group: normal diet and drinking water were given from the beginning of modeling, and normal saline (saline, Veh) was injected intraperitoneally for 2 weeks after the operation as a control of brass;

[0015] (3) Renal hypertension-Flavonoid glycosides group: Normal diet and drinking water were given from the beginning of modeling, and flavonoid glycosides (30 mg / kg) were given continuous intraperitoneal injection for 2 weeks after 2 weeks after operation.

Embodiment 3

[0016] Embodiment 3 rat blood pressure measurement

[0017] The systolic blood pressure, diastolic blood pressure, mean arterial pressure and heart rate of rats in awake state were measured by IITC animal non-invasive tail artery blood pressure measurement system. Rats need to be warmed at 34°C for 10-20 minutes before SBP measurement to obtain a stable pulse pressure, and the average value of 10 measurements is taken as the blood pressure and heart rate of the rat.

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Abstract

The invention relates to application of Vaccarin in preparation of antihypertensive drugs and belongs to the field of application of traditional Chinese medicine drugs. The Vaccarin is applied to the development of antihypertensive related drugs, so as to prepare better hypertension treatment methods. According to the application, after the Vaccarin is injected to the abdominal cavity of a rat suffering from renovascular hypertension, the systolic pressure, diastolic pressure and mean arterial pressure of the hypertensive rat are remarkably lowered, and cardiovascular remodeling is remarkably improved, so that the Vaccarin can be used for remarkably improving hypertensive and cardiovascular pathological changes, is a traditional Chinese medicine for treating the hypertension and can be developed as novel antihypertensive drugs, healthcare products and nutrients, and thus, a new way and means is provided for treating the hypertension.

Description

technical field [0001] The invention relates to the development of antihypertensive traditional Chinese medicines, and specifically designs the application of blagliaxin flavonoid glycosides in the preparation of antihypertensive medicines, belonging to the application field of traditional Chinese medicines. Background technique [0002] Hypertension is the most common chronic non-communicable disease and one of the most important risk factors for cardiovascular diseases. Hypertension is the main cause of death and disability in the world. In 2013, the cost of treating hypertension accounted for 6.61% of my country's total health expenditure. Although the awareness rate, treatment rate and control rate of hypertension in my country are rising, they are still at a low level, and only 6.1% of hypertensive patients have been effectively controlled. The incidence of hypertension is high, the harm is great, and the treatment effect is not ideal. The complications such as myocard...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P9/12A23L33/00
CPCA61K31/7048A23V2002/00A23V2200/326
Inventor 邱丽颖孙海建朱雪雪蔡维维周跃涛
Owner JIANGNAN UNIV
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