Preparation and application of a reduction-sensitive nanomicelle

A nanomicelle, sensitive technology, applied in the field of preparation and application of amphiphilic block polymers, can solve problems such as inability to release drugs and reduce drug efficacy, and achieve slow drug release, overcoming easy leakage, and high efficiency. effect of treatment
CN106727307BActive Publication Date: 2019-07-02XUZHOU NORMAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
XUZHOU NORMAL UNIVERSITY
Publication Date
2019-07-02

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Abstract

The invention relates to preparation and application of a reducing sensitive nano-micelle, belonging to preparation and application of an amphiphilic block polymer. A hydrophilic section and a hydrophobic section of the amphiphilic block polymer are connected with each other by a reducing responsive sulfur-sulfur bond; the nano-micelle is formed by self-assembling; the reducing sensitive nano-micelle consists of a shell and an inner core, wherein the shell is a hydrophilic polymer, and the inner core is a hydrophobic polymer; the hydrophilic section of the amphiphilic block polymer is polyphosphate, the hydrophobic section of the amphiphilic block polymer is poly(benzyl glutamate), and the hydrophilic section and the hydrophobic section of the amphiphilic block polymer are connected with each other by the reducing responsive sulfur-sulfur bond. The reducing sensitive nano-micelle has the advantages that the drug-loaded nano-micelle is difficult to dissociate outside the cells or in the blood, so that the drug encapsulated in the nano-micelle is enabled to be stable; once the nano-micelle enters the cancer cell, the sulfur-sulfur bond can be disconnected by glutathione which is a reducing matter in the cell, so that the nano-micelle is rapidly dissociated, the anti-cancer drug encapsulated in the nano-micelle can be rapidly and effectively released out, and an effective treatment effect is achieved; the reducing sensitive nano-micelle overcomes the defects that the drug is easy to leak in vivo, low in transport efficiency, slow in intracellular release speed, and the like.
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Description

technical field

[0001] The invention relates to the preparation and application of an amphiphilic block polymer, in particular to the preparation and application of a reduction-sensitive nano-micelle. Background technique

[0002] In recent decades, micelles formed by amphiphilic block polymers have attracted great interest in the field of drug delivery. Various nanocarriers have been widely developed to improve the efficacy of cancer chemotherapy, and these nanocarriers have the ability to target and control the release of anticancer drugs due to their enhanced permeability and retention (EPR) effect. Polymeric micelles based on amphiphilic block polymers are a kind of anticancer drug nanocarriers widely used in drug delivery, which have several excellent salient features, including long circulation time, good drug solubility, and tumor site passive targeting ability (Deng, et al. J. Nano Today 2012, 7, 467-480). Amphiphilic polymers can self-assemble in water to form pol...

Claims

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