A kind of dabigatran etexilate mesylate pellet and preparation method thereof

A technology of dabigatran etexilate mesylate and gatran etexilate pellets, which is applied in the field of medicine, can solve the problems of dabigatran etexilate mesylate raw materials being wet, large increase in substances, and reduced curative effect, and achieve prescription and Stable and reliable, fast drug application, good film-forming effect
CN106727414BActive Publication Date: 2019-06-07哈药集团股份有限公司 +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
哈药集团股份有限公司
Publication Date
2019-06-07

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Abstract

The invention discloses a methane sulfonic acid pradaxa pellet and a preparation method and belongs to the technical field of medicals. The structure of the pellet comprises a pellet core, an isolating layer and a drug-containing layer, wherein the isolating layer is wrapped on the outer layer of the pellet core; the drug-containing layer is wrapped on the outer layer of the isolating layer; glycine and hydroxypropyl methylcellulose are contained in the pellet core; hydroxypropyl methylcellulose phthalic ester and talcum powder are contained in the isolating layer; methane sulfonic acid pradaxa, methyl methacrylate and talcum powder are contained in the drug-containing layer. The surface of the isolating layer of the pellet prepared according to the invention is round and smooth; no so-called satellite particle exists; the completeness of the isolating layer is not influenced, so that the active ingredients and the glycine can be effectively isolated in space and the stability of the active ingredients of the preparation in a storage process can be guaranteed. The methane sulfonic acid pradaxa pellet prepared according to the invention has the effects of preventing and treating cerebral ischemia and systemic embolism diseases.
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Description

technical field

[0001] The invention relates to dabigatran etexilate mesylate pellets and a preparation method, belonging to the technical field of medicine. Background technique

[0002] With the aging of the population and the increase in the incidence of cardiovascular diseases, the current anticoagulant gold standard drugs can no longer adapt and meet these needs. It is an inevitable trend that successively improved new drugs are approved for marketing, so it is expected that the market structure of anticoagulant drugs will change.

[0003] What needs to be pointed out is that anticoagulation and antiplatelet therapy are different. Aspirin, clopidogrel, etc. are antiplatelet therapy, not anticoagulation. Both anticoagulation and antiplatelet therapy are antithrombotic treatments, but their specific mechanisms of action are different. In addition, anticoagulation therapy is generally stronger than antiplatelet therapy.

[0004] First, platelets play a very important rol...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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