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Traditional Chinese medicine composition for treating low-risk myeloproliferative disorder syndrome and preparation method of traditional Chinese medicine composition

A composition and a technology for endangering bone marrow, which are applied in the directions of drug combination, pharmaceutical formula, medical raw materials derived from birds, etc., can solve the problems of large difference in treatment, poor curative effect, poor effect, etc., and achieve a simple preparation process and good application prospect. , the effect of rich medicinal sources

Active Publication Date: 2017-05-31
刘清池 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are different types of MDS, and the treatment of each type is quite different. Among the various types of MDS, refractory anemia (RA), refractory leukopenia (RN), and refractory anemia with ring sideroblastosis ( RAS), refractory cytopenia with multilineage hematopoiesis (RCMD), most of them are low-risk MDS, mostly in the elderly, usually treated with androgen and hematopoietic cytokines in clinic, but the curative effect is not good, and Western medicine Chemotherapy is less effective

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] This embodiment relates to a traditional Chinese medicine composition for treating low-risk myelodysplastic syndrome and its preparation.

Embodiment 11

[0018] A decoction concentrated mixture of traditional Chinese medicines for the treatment of low-risk myelodysplastic syndrome, each dose includes 12g of raw raw sun-dried ginseng, 25g of heterophylla, 22g of rehmannia glutinosa, 26g of astragalus, 21g of angelica, 23g of Polygonatum, and Bugu 14g fat, 15g Anemarrhena, 17g mistletoe, 12g medlar, 14g cork, 16g arborvitae leaves, 11g gallinaceae, 12g amomum; weigh and mix the above raw materials according to the amount, clean them, put them in a normal Add 2500g of water to the casserole, decoct for 1.5 hours, pour the liquid medicine into a non-metallic container, add 1500g of water for the second time, decoct for 1 hour, combine the decoction liquid, filter, concentrate, subpackage, and extinguish in a horizontal hot press The bacteria cabinet is conventionally sterilized to obtain the decoction concentrated mixture of the traditional Chinese medicine composition.

[0019] The water-decoction concentrated mixture of the tradi...

Embodiment 12

[0021] A granule of a traditional Chinese medicine composition for treating low-risk myelodysplastic syndrome, comprising 13 parts of raw sun-dried ginseng, 26 parts of heterophylla, 24 parts of rehmannia glutinosa, 28 parts of astragalus, 20 parts of angelica, 22 parts of Polygonatum, 16 parts of bone fat, 17 parts of Anemarrhena, 15 parts of mistletoe, 14 parts of medlar, 13 parts of Phellodendron arborvitae, 19 parts of arborvitae leaves, 12 parts of gallinaceous gold, 10 parts of amomum; Take and mix, clean and dry in an oven at 80°C, pulverize and grind, pass through a 50-mesh sieve, add β-cyclodextrin as a pharmaceutical excipient, pack separately, each bag contains 8g of medicine, and make a traditional Chinese medicine composition. Granules.

[0022] The granule of the traditional Chinese medicine composition is used to treat low-risk myelodysplastic syndrome patients, and the dosage is twice a day, 8 to 16 grams of medicine each time.

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PUM

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Abstract

The invention discloses a traditional Chinese medicine composition for treating a low-risk myeloproliferative disorder syndrome. The traditional Chinese medicine composition comprises the following raw material ingredients in parts by weight: 10-15 parts of suncured ginseng, 20-30 parts of radix pseudostellariae, 20-25 parts of prepared rehmannia root, 20-30 parts of astragalus mongholicus, 20-25 parts of Chinese angelica, 20-25 parts of sealwort, 10-20 parts of fructus psoraleae, 10-20 parts of rhizoma anemarrhenae, 10-20 parts of mistletoe, 10-20 parts of fructus lycii, 10-15 parts of amoorcorn tree bark, 15-20 parts of cacumen biotae, 10-15 parts of endothelium corneum gigeriae galli and 10-15 parts of fructus amomi. With the adoption of the technical scheme, the ingredients in the traditional Chinese medicine composition have mutual promotion effect, jointly reach effects of tonifying vigour, nourishing yin, promoting sperm production, benefiting marrow and generating blood, and achieves a curative effect of treating both principal and secondary aspects of a disease. A preparation technology of the traditional Chinese medicine composition is simple and convenient; the raw material ingredients are not required to be subjected to complicated treatment; a medicine source is rich; the traditional Chinese medicine composition has good application prospects for treating the low-risk myeloproliferative disorder syndrome.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for treating low-risk myelodysplastic syndrome and a preparation method of the traditional Chinese medicine composition. Background technique [0002] Myelodysplastic syndrome (MDS) is a group of heterogeneous clonal diseases originating from committed hematopoietic myeloid stem cells or pluripotent stem cells. The risk of hematopoiesis and malignant transformation is increased. The main features are ineffective hematopoiesis and high risk of evolving into acute myeloid leukemia. The clinical manifestations are abnormal changes in the quality and quantity of hematopoietic cells. The incidence of MDS is about 10-12 people per 100,000 people, 50%-70% of the cases are over 50 years old, and the ratio of male to female is about 2:1. 30% to 60% of MDS patients transform into leukemia, and the cause of death ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61P7/00A61P35/02A61K35/57
CPCA61K35/57A61K36/14A61K36/185A61K36/232A61K36/258A61K36/36A61K36/481A61K36/487A61K36/756A61K36/804A61K36/815A61K36/8964A61K36/8969A61K36/9064A61K2236/331A61K2236/39A61K2300/00
Inventor 刘清池郭丽华赵增仁尹婉宜马兵张丽红
Owner 刘清池