Compound employing quinazolinone derivative as mother nucleus and application of compound
A quinazolinone and compound technology, applied in organic chemistry, chemical instruments and methods, electrical components, etc., can solve problems such as limited applications and lower triplet energy levels
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[0075] Example 1 Synthesis of Compound 22
[0076]
[0077] In a 250ml four-neck flask, add 0.01mol 3-bromo-6,6-dimethylindolo[2,1-b]quinazoline 12(6H)-one, 0.015mol under a nitrogen atmosphere Compound B1, 0.03mol sodium tert-butoxide, 1×10 -4 mol Pd 2 (dba) 3 , 1×10 -4 mol of tri-tert-butyl phosphine, 150ml of toluene, heating and refluxing for 24 hours, sampling point plate, reaction complete, natural cooling, filtration, rotary evaporation of the filtrate, and silica gel column to obtain the target product with a purity of 97.36% and a yield of 66.4%. HPLC-MS (m / z): The theoretical value is 559.23, and the measured value is 559.42.
Example Embodiment
[0078] Example 2 Synthesis of Compound 26
[0079]
[0080] In a 250ml four-neck flask, add 0.01mol 3-bromo-6,6-dimethylindolo[2,1-b]quinazoline 12(6H)-one, 0.015mol under a nitrogen atmosphere Compound B2, 0.03mol sodium tert-butoxide, 1×10 -4 mol Pd 2 (dba) 3 , 1×10 -4 mol of tri-tert-butyl phosphine, 150 ml of toluene, heating and refluxing for 24 hours, sampling point plate, reaction complete, natural cooling, filtration, rotary evaporation of the filtrate, and silica gel column to obtain the target product with a purity of 96.59% and a yield of 59.8%. HPLC-MS (m / z): The theoretical value is 559.23, and the measured value is 559.67.
Example Embodiment
[0081] Example 3 Synthesis of Compound 42
[0082]
[0083] In a 500ml four-neck flask, add 0.01mol 2-bromo-benzo[d]benzo[4,5]imidazole[2,1-b]oxazole and 0.015mol compound C1 under a nitrogen atmosphere. Dissolve in mixed solvent (180ml toluene, 90ml ethanol), then add 0.03mol Na 2 CO 3 Aqueous solution (2M), then add 0.0001mol Pd(PPh 3 ) 4 , Heating and refluxing for 10-24 hours, sampling point plate, the reaction is complete. Natural cooling, filtration, rotary evaporation of the filtrate, and silica gel column to obtain the target product with an HPLC purity of 97.80% and a yield of 67.5%. HPLC-MS (m / z): The theoretical value is 635.26, and the measured value is 635.68.
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