Rutin extraction method

An extraction method and rutin technology, which is applied in the field of extraction of new rutin, can solve the problems of difficult purification, high and low purity of rutin, etc., and achieve the effects of shortening the extraction cycle, improving production purity, and simple extraction process

Inactive Publication Date: 2017-05-31
衡阳市骏杰化工有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to overcome the problems of complex extraction process, long extraction period, more impurities, low purity and difficult purification from Huai Mi in the prior art, and provide a process for extracting rutin from Huai Mi. Simple, short extraction cycle, high purity of extracted rutin, less impurities, and low cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A method for extracting rutin, comprising the steps of:

[0029] Step 1: steam Sophora japonica in a container for 1 hour, crush it after cooling, and put it in an extraction tank;

[0030] Second step: adding sodium metabisulfite and borax, its weight ratio is 0.8:4.5;

[0031] Step 3: Add 20% ethanol solvent, stir and extract for 50 minutes in a water bath at 60°C;

[0032] Step 4: Filter Sophora japonica with gauze, centrifuge at 2800r / m for 6min, and collect the supernatant;

[0033] Step 5: Add 20% ethanol solvent to the filtered Sophora japonica again, stir and extract in a water bath at 60°C for 50 minutes, filter out Sophora japonica with gauze, centrifuge at 2800r / m for 6 minutes, and collect the supernatant;

[0034] The 6th step: combine the filtrate obtained by two times of filtration;

[0035] Step 7: Concentrate the filtrate at 85°C, add ethanol, and refrigerate overnight;

[0036] Step 8: Filter, take the filtrate, and concentrate under reduced pressu...

Embodiment 2

[0040] A method for extracting rutin, comprising the steps of:

[0041] Step 1: steam Sophora japonica in a container for 0.9 hours, crush it after cooling, and put it in an extraction tank;

[0042] Second step: adding sodium metabisulfite and borax, its weight ratio is 1.2:5.5;

[0043] Step 3: Add 20% ethanol solvent, stir and extract for 60 minutes in a water bath at 70°C;

[0044] Step 4: Filter out Sophora japonica with gauze, centrifuge at 3200r / m for 8min, and collect the supernatant;

[0045] Step 5: add 20% ethanol solvent to the filtered Sophora japonica again, stir and extract in a water bath at 70°C for 60 minutes, filter out Sophora japonica with gauze, centrifuge at 3200r / m for 8 minutes, and collect the supernatant;

[0046] The 6th step: combine the filtrate obtained by two times of filtration;

[0047] Step 7: Concentrate the filtrate at 85°C, add ethanol, and refrigerate overnight;

[0048] Step 8: Filter, take the filtrate, and concentrate under reduced...

Embodiment 3

[0052] A method for extracting rutin, comprising the steps of:

[0053] Step 1: steam Sophora japonica in a container for 1 hour, crush it after cooling, and put it in an extraction tank;

[0054] Second step: add sodium pyrosulfite and borax, and its weight ratio is 1:5;

[0055] Step 3: Add 20% ethanol solvent, stir and extract for 55 minutes in a water bath at 65°C;

[0056] Step 4: Filter out Sophora japonica with gauze, centrifuge at 3000r / m for 7min, and collect the supernatant;

[0057] Step 5: add 20% ethanol solvent to the filtered Sophora japonica again, stir and extract in a water bath at 65°C for 55 minutes, filter out Sophora japonica with gauze, centrifuge at 3000r / m for 7 minutes, and collect the supernatant;

[0058] The 6th step: combine the filtrate obtained by two times of filtration;

[0059] Step 7: Concentrate the filtrate at 85°C, add ethanol, and refrigerate overnight;

[0060] Step 8: Filtrate, take the filtrate, and concentrate under reduced press...

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Abstract

The present invention provides a rutin extraction method, which comprises: steaming flos sophorae immaturus for 0.9-1 h with a container, cooling, pressing to achieve a crushed state, and placing into an extraction tank; adding borax and sodium metabisulfite according t a weight ratio of 0.8-1.2:4.5-5.5; adding a 20% ethanol solvent, and carrying out stirring extraction for 50-60 min in a water bath with a temperature of 60-70 DEG C; filtering out the flos sophorae immaturus by using gauze, carrying out centrifugation for 6-8 min at a speed of 2800-3200 r / m, and collecting the supernatant; adding a 20% ethanol solvent to the obtained flos sophorae immaturus, carrying out stirring extraction for 50-60 min in a water bath with a temperature of 60-70 DEG C, filtering out the flos sophorae immaturus by using gauze, carrying out centrifugation for 6-8 min at a speed of 2800-3200 r / m, and collecting the supernatant; combining the two filtrates; concentrating the mixed filtrate at a temperature of 85 DEG C, adding ethanol, carrying out cold preservation standing overnight; filtering, taking the filtrate, and carrying out pressure reducing concentration at a temperature of 65-70 DEG C to remove the ethanol; adding concentrated and thick hydrochloric acid and adjusting the PH value to 3.2-5.0, and carrying out cold preservation standing overnight; and weighing and packaging. With the rutin extraction method of the present invention, the technical problems of not high rutin extraction purity, complex process, long extraction period and low efficiency in the prior art are solved.

Description

technical field [0001] The invention relates to the field of rutin extraction, in particular to a novel rutin extraction method. Background technique [0002] Rutin, also known as rutin, vitamin P, purple quercetin, rutin, rutin powder, Lutong, Luotong, purperitin. The main uses are anti-inflammation, anti-virus, etc. It is clinically used to prevent and treat cerebral hemorrhage, hypertension, retinal hemorrhage, purple scar and acute hemorrhagic nephritis. Its pharmacological action is: rutin belongs to vitamin medicine, which can reduce the permeability and fragility of capillaries, maintain and restore the normal elasticity of capillaries. The production process of rutin is mainly completed by alcohol extraction, extraction, chromatography, crystallization and other processes. However, the existing rutin extraction process has high processing cost, complex process, low purity and poor quality. Contents of the invention [0003] The purpose of the present invention i...

Claims

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Application Information

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IPC IPC(8): C07H17/07C07H1/08
Inventor 仇协强刘兆容
Owner 衡阳市骏杰化工有限公司
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