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Nano-coagulant for blood

A blood coagulant and coagulant technology, applied in the field of blood nano-coagulants, can solve the problems of inaccurate test results, high cost, interference of test results, etc., and achieve easy cleaning and drying, no heat source, and stable blood sugar results. Effect

Inactive Publication Date: 2017-05-31
湖北金杏科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, in clinical serum biochemical testing, a coagulant is added to the blood to shorten the coagulation time. The traditional coagulant is kaolin, cephalin and thrombin, but the first two components will interfere with the test results, resulting in The test results are inaccurate, and thrombin needs to be equipped with special equipment, which costs a lot

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Measure 3ml of α-hydrogen-ω-hydroxyl (oxy-1,2-ethanediyl) polymer, 4g of polyvinylpyrrolidone and 1000ml of isopropanol, mix them well using a high shear disperser until the mixed solution is clear Transparent to obtain mixed solution A; measure 60ml polysorbate, 30ml polysorbate and 11g silicon dioxide powder to mix, stir, and then use a high-pressure homogenizer to homogenize three times to obtain mixture B; mix the mixture obtained in step (1) Mix liquid A and mixture B obtained in step (2), and shake well.

Embodiment 2

[0031] Measure 2ml of α-hydrogen-ω-hydroxyl (oxy-1,2-ethylenediyl) polymer, 2.5g of polyvinylpyrrolidone and 1000ml of isopropanol, mix, and mix thoroughly using a high-shear disperser until a mixed solution It is clear and transparent to obtain mixed solution A; measure 80ml polysorbate, 40ml polysorbate and 7g silicon dioxide powder to mix, stir, and then use a high-pressure homogenizer to homogenize three times to obtain mixture B; The mixture A and the mixture B obtained in step (2) are mixed and shaken evenly.

Embodiment 3

[0033] Measure 1ml of α-hydrogen-ω-hydroxyl (oxy-1,2-ethanediyl) polymer, 2g of polyvinylpyrrolidone and 1000ml of isopropanol, mix them well using a high shear disperser until the mixed solution is clear Transparent to obtain mixed solution A; measure and mix 40ml polysorbate, 20ml polysorbate and 5g silicon dioxide powder, stir, and then use a high-pressure homogenizer to homogenize three times to obtain mixture B; mix the mixture obtained in step (1) Mix liquid A and mixture B obtained in step (2), and shake well.

[0034] Effect example

[0035] Spray the coagulants obtained in Examples 1, 2 and 3 on the inner wall of the blood collection container, spray 25 μL of each blood collection tube, then dry it with hot air, and carry out vacuum plugging according to the specification of 5 ml to complete the blood collection tube. Manufactured for subsequent use. Use the prepared blood collection tubes to collect venous blood samples, collect 5ml from each blood collection tube,...

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Abstract

The invention belongs to the technical field of nano-coagulants for blood, and discloses a nano-coagulant for blood. The nano-coagulant for blood is characterized by being prepared from a polymer of alpha-hydrogen-omega-hydroxyl (oxygen-1,2-ethanediyl), polyvinylpyrrolidone, polysorbate, polysorbitol, silicon dioxide powder and isopropanol, wherein the volume ratio of the polymer of alpha-hydrogen-omega-hydroxyl (oxygen-1,2-ethanediyl) to the polysorbate to the polysorbitol to the isopropanol is equal to (1-5): (60-80): (25-45): 1000; the mass volume ratio of the polyvinylpyrrolidone to the isopropanol is equal to (3-6g): 1000ml; the mass volume ratio of the silicon dioxide powder to the isopropanol is equal to (8-16g): 1000ml. The nano-coagulant provided by the invention can effectively shorten blood coagulation time, avoids the phenomenon of wall hanging of the blood, is good in serum separation effect, does not interfere the detection results of biochemistry and immunology experiments, is long in shelf life and has excellent performance; the nano-coagulant is sterile water-based type, is safe in transportation and free from bacteria and heat source, and can stabilize the blood glucose result.

Description

technical field [0001] The invention belongs to the technical field of blood nano-coagulants, and relates to a blood nano-coagulant. Background technique [0002] Serum refers to the light yellow transparent liquid separated from fibrinogen in plasma after blood coagulation. Cells adhere to the wall from mechanical damage and have some protective effects on cells in culture. It is one of the main specimens for clinical biochemical and immunological tests. Under normal circumstances, it takes more than 60 minutes for blood samples to completely coagulate after being isolated, which is difficult to meet the needs of laboratories for rapid testing. [0003] Accelerated blood collection tubes are widely used in medical testing, and the quality of the coagulant is very important to the test results. At present, in clinical serum biochemical testing, a coagulant is added to the blood to shorten the coagulation time. The traditional coagulant is kaolin, cephalin and thrombin, but...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/28
CPCG01N1/28
Inventor 杨柯
Owner 湖北金杏科技发展有限公司
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