Fexofenadine hydrochloride dry suspension preparation and preparation method thereof

A technology of fexofenadine and dry suspension, applied in the field of fexofenadine hydrochloride dry suspension preparation and its preparation, can solve the problem of stability, fluidity suspension stability, dispersibility , Taste defects and other problems, to achieve the effect of good taste, easy storage and rapid absorption

Active Publication Date: 2017-06-09
SINOPHARM GUANGDONG GLOBAL PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved by this invention is in order to solve the stability, fluidity that existing fexofenadine hydrochloride dry suspension exists and the stability of the suspension that it prepares, dispersibility, mouthfeel aspect defect, but a kind of fexofenadine hydrochloride dry suspension preparation and preparation method thereof are provided

Method used

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  • Fexofenadine hydrochloride dry suspension preparation and preparation method thereof
  • Fexofenadine hydrochloride dry suspension preparation and preparation method thereof
  • Fexofenadine hydrochloride dry suspension preparation and preparation method thereof

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Embodiment 1

[0031] Product prescription (Table 1)

[0032] Prescription (g) 1(% content%) Fexofenadine Hydrochloride 0.8 xanthan gum 0.76 Poloxamer 407 0.15 Disodium hydrogen phosphate dodecahydrate 3.52 Sodium dihydrogen phosphate monohydrate 2.23 blueberry flavor 0.55 Sour Strawberry Flavor 0.55 Sucralose 1.2 Glyceryl behenate 0.24 sucrose 60 xylitol 30

Embodiment 2

[0034] Product prescription (Table 2)

[0035] Prescription (g) 2(% content%) Fexofenadine Hydrochloride 4.0 Hydroxyethyl cellulose 1.0

[0036] Sodium citrate 0.98 citric acid 0.52 Sweet Orange Flavor 0.1 cream flavor 0.1 saccharin 0.7 Carbomer 974 2.6 sucrose 60 xylitol 30

Embodiment 3

[0038] Product prescription (Table 3)

[0039] Prescription (g) 3(% content%) Fexofenadine Hydrochloride 2.3 Povidone 0.5 Disodium hydrogen phosphate dodecahydrate 5.76 Sodium dihydrogen phosphate monohydrate 4.24 orange flavor 1.0 coconut flavor 1.0 Acesulfame K 0.2 Carbomer 934 5.0 Micropowder silica gel 53.3 Maltitol 26.7

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Abstract

The invention discloses a fexofenadine hydrochloride dry suspension preparation and a preparation method thereof. The preparation comprises the following components in percentage by mass: 0.8-4% of fexofenadine hydrochloride, 80-93% of filler, 0.2-1.2% of sweetening agent, 0.5-1% of suspending agent, 0.2-2% of flavoring agent, 0.2-5% of taste masking agent, 0-0.6% of wetting agent and 1.5-10% of citric acid buffer salt or phosphoric acid buffer salt, totaling 100%. The fexofenadine hydrochloride dry suspension preparation is prepared by wet-process granulation. The fexofenadine hydrochloride dry suspension preparation has the advantages of high stability, favorable flowability and high storability. The suspension prepared from the preparation has the advantages of high absorption speed, high bioavailability, favorable mouthfeel and high stability, and is convenient to take.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a fexofenadine hydrochloride dry suspension preparation and a preparation method thereof. Background technique [0002] Fexofenadine is the active metabolite of the antihistamine terfenadine. The main advantage is that it removes the cardiotoxicity of the parent terfenadine and can exert its anti-allergic effect through various mechanisms. In view of the above advantages, fexofenadine has been marketed in the form of tablets, capsules, orally disintegrating tablets, and oral suspensions. However, the above formulations have their limitations. After fexofenadine hydrochloride is made into a dry suspension, it can not only solve the problem of swallowing difficulties of tablets and capsules for children and some patients, but also avoid the problem of complicated preparation of orally disintegrating tablets and high cost. , At the same time, it avoids the trouble of pre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/445A61P37/08
CPCA61K9/1635A61K9/1652A61K31/445
Inventor 何军袁春平孙艳冬林碧珊陆伟根虞丽芳张然然杨亚妮
Owner SINOPHARM GUANGDONG GLOBAL PHARMA CO LTD
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