A core-shell mesoporous silica microsphere material with adjustable surface roughness and preparation method thereof

A technology of surface roughness and silica microspheres, applied in chemical instruments and methods, separation methods, medical preparations containing active ingredients, etc., can solve problems such as the design and synthesis of core-shell mesoporous silica microspheres that have not been reported. , to achieve the effect of simple method, high specific surface area and large pore volume

Active Publication Date: 2020-01-10
FUDAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, the design and synthesis of core-shell mesoporous silica microspheres with tunable surface roughness has not been reported.

Method used

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  • A core-shell mesoporous silica microsphere material with adjustable surface roughness and preparation method thereof
  • A core-shell mesoporous silica microsphere material with adjustable surface roughness and preparation method thereof
  • A core-shell mesoporous silica microsphere material with adjustable surface roughness and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021](1) 0.2 g of Fe with a particle size of 500 nm 3 o 4 Nanoparticles@phenolic resin microspheres were ultrasonically dispersed into 80 ml dissolved with 0.5 g of cetyltrimethylammonium bromide (C 16 TAB) and 0.5 ml of concentrated ammonia water, ultrasonically dispersed, then slowly added 7 ml of a mixed solvent of tetraethyl orthosilicate and n-hexane (volume ratio: 2:5), and stirred at 20 degrees for 12 hours, then , the microspheres were separated magnetically, washed three times with ethanol, and dried at 40°C.

[0022] (2) Add the microspheres obtained above into 60 ml of acetone, reflux at 80°C for 24 h, then separate and wash with ethanol for 3 times to obtain Fe with rough surface 3 o 4 @phenolic resin @mesoporous SiO 2 Core-shell microspheres.

[0023] Such as figure 1 As shown, the particle size of the microsphere is about 560 nm, the thickness of the mesoporous shell is about 30 nm, the size of the raised particles on the surface is 80 nm, the measured co...

Embodiment 2

[0025] (1) 0.3 g of Fe with a particle size of 500 nm 3 o 4 Nanoparticles@phenolic resin microspheres were ultrasonically dispersed into 80 ml dissolved with 0.6 g of cetyltrimethylammonium bromide (C 16 TAB) and 1.0 ml of concentrated ammonia water, ultrasonically dispersed, then slowly added 20 ml of a mixed solvent of tetraethyl orthosilicate and n-hexane (volume ratio 1:4), and stirred at 20 degrees for 24 h, Subsequently, the microspheres were separated by centrifugation, washed three times with ethanol, and dried at 40°C.

[0026] (2) The microspheres obtained above were heated up to 350°C at 1°C / min in a nitrogen atmosphere, calcined for 3 h, and after cooling, Fe with rough surface was obtained. 3 o 4 @phenolic resin @mesoporous SiO 2 Core-shell microsphere materials.

[0027] Such as figure 2 As shown, the particle size of the microsphere is about 680 nm, the thickness of the mesoporous shell is about 90 nm, the size of the raised particles on the surface is 1...

Embodiment 3

[0029] (1) 0.8g of SiO with a particle size of 600 nm 2 @Phenolic resin microspheres were ultrasonically dispersed to 150 ml dissolved with 1.0 g of dodecyltrimethylammonium bromide (C 12 TAB) and 3 ml of concentrated ammonia water, ultrasonically dispersed, then slowly added 20 ml of a mixed solvent of tetraethyl orthosilicate and n-hexane (volume ratio 1:3), and stirred at 20°C for 18 h, Subsequently, the microspheres were separated by centrifugation, washed three times with ethanol, and dried at 40°C.

[0030] (2) The microspheres obtained above were heated up to 350 degrees at 1 °C / min in a nitrogen atmosphere, calcined for 3 h, and after cooling, SiO with rough surface was obtained. 2 @phenolic resin @mesoporous SiO 2 Core-shell microsphere materials.

[0031] Such as image 3 As shown, the particle size of the microsphere is about 900 nm, the thickness of the mesoporous shell is about 150 nm, the size of the raised particles on the surface is 400 nm, the measured con...

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Abstract

The invention belongs to the technical field of advanced nanocomposite and specifically relates to a surface roughness-adjustable core-shell mesoporous silica microsphere material and a preparation method thereof. According to the invention, in-situ hydrolysis silicon oxide oligomer and a cationic surfactant are orderly assembled on the surface of a core material and deposited on the interface in an oil-water mixed system under the action of a catalyst. Therefore, the core material is coated with a layer of rough silicon oxide / cationic surfactant compound. Further, by removing the cationic surfactant, the shell layer is silicon oxide microspheres with ordered mesopore channels which are vertical to the centre of sphere and spread out, and the surface of the microspheres are rugged and tough. The prepared composite material can store and transport objects and is a very ideal carrier. By combining mesopores and the roughness-adjustable surface, wide application range of the material in the fields of bioseparation, drug delivery, catalyst loading, etc. can be widely broadened. The method is simple; the raw materials are easily available; and the product is suitable for enlarge production.

Description

technical field [0001] The invention belongs to the technical field of advanced nanocomposite materials, and in particular relates to a core-shell mesoporous silicon oxide microsphere material with adjustable surface roughness and a preparation method thereof. Background technique [0002] In recent years, due to the effective combination of unique core-shell structure and mesoporous materials, mesoporous composite materials with core-shell structure have high specific surface area, large pore volume, rich mesoscopic structure, and both inner core and outer shell layers. With excellent properties, it has broad application prospects in bioseparation, drug delivery, catalytic loading, etc. (Hu, H.; Zhang, J.T.; Guan, B. Y.; Lou, X. W. Angew. Chem. Int. Ed. 2016, 55, 9512. Feyen, M.; Weidenthaler, C.; Schuth, F.; Lu, A. H. J. Am 2010, 132, 6791.Li, Z.; Zhang, J. T.; Guan, B. Y.; Wang, D.; Liu, L. M.; Lou, X. W. Nat.Commun. Liu, J.; Yang, H. Q.; Kleitz, F.; Chen, Z. G.; Yang, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D17/022A61K9/16A61K41/00A61K47/02A61K47/34
CPCA61K9/1676A61K41/00A61K41/0052A61K47/02A61K47/34B01D17/0202A61K2300/00
Inventor 邓勇辉岳秦张愉罗维
Owner FUDAN UNIV
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