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A modification method of blood purification material

A blood purification and modification technology, applied in dialysis systems, textiles and papermaking, fiber processing, etc., can solve the problems of high price, difficult to effectively remove, and high cost of blood purification materials, and achieve simple operation, good stability, and modification. high success rate

Active Publication Date: 2017-10-24
佛山市博新生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Adsorbent resin can effectively absorb and remove macromolecular toxins, but its price is relatively expensive, and the carrier cost of blood purification materials is relatively high
Generally, the price of hemodialysis membrane is cheap, but it is difficult to effectively remove macromolecular toxins such as β2-microglobulin. It is often necessary to combine a dialyzer with a perfusion device containing an adsorbent resin to simultaneously remove small and medium macromolecular toxins.
High-throughput dialyzers can remove some macromolecular toxins such as β2-microglobulin, but the removal effect is not ideal
[0005] The current dialysis membrane can only effectively remove small molecule toxins, but it is difficult to effectively remove large molecule toxins

Method used

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  • A modification method of blood purification material
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  • A modification method of blood purification material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Synthesis of 1-1 Hexadecyl Methacrylate Copolymer

[0040] In 250mL alcohol solution, add 51.1g cetyl methacrylate, 42.8g hydroxyethyl methacrylate and 6.1g vinylpyrrolidone monomer (molar ratio about 3:6:1), then add 0.1g trigger Azobisisobutyronitrile AIBN and 0.1 g of glycidyl methacrylate (GMA) were stirred and reacted at 70° C. for 5 hours. After the reaction is completed, the polymerization solution is added dropwise into water to precipitate the copolymer.

[0041] 1-2 coating

[0042] Take hexadecyl methacrylate, hydroxyethyl methacrylate (HEMA) and vinylpyrrolidone copolymer, dissolve in 80% alcohol solution to make 1% coating solution. 1g of dialysis membrane (polysulfone hollow fiber commodity, wall thickness 40um, inner diameter 200um, pore diameter about 3nm, effective area 1.5m 2 ) soaked in 10mL of coating solution, and dried at 25°C for 24 hours.

Embodiment 2

[0044] Synthesis of 2-1 Octadecyl Methacrylate Copolymer

[0045] In 200mL alcohol solution, add 20.2g of octadecyl methacrylate, 62.2g of hydroxyethyl methacrylate and 17.6g of methacryloyloxyethyl phosphorylcholine monomer (molar ratio 1:8:1 ), then add 0.05g of initiator azobisisobutyronitrile AIBN and 0.07g of glycidyl methacrylate (GMA), and react with stirring at 60°C for 5 hours. After the reaction is completed, the polymerization solution is added dropwise into water to precipitate the copolymer.

[0046] 2-2 coating

[0047] Take stearyl methacrylate, HEMA and methacryloyloxyethyl phosphorylcholine copolymer, dissolve in 75% alcohol solution to make 1% coating solution. 1 g of a dialysis membrane (polyethersulfone hollow fiber commercial product) was soaked in 10 mL of coating solution, and dried at 25° C. for 24 hours.

Embodiment 3

[0049] Synthesis of 3-1 Hexadecyl Methacrylate Copolymer

[0050] Random copolymers were synthesized by conventional free radical polymerization. In 250mL alcohol solution, add 52.2g cetyl methacrylate, 43.8g hydroxyethyl methacrylate and 4.0g acrylic acid monomer (molar ratio 3:6:1), then add 0.1g initiator azo Diisobutyronitrile AIBN and 0.08 g of glycidyl methacrylate (GMA) were stirred and reacted at 60° C. for 5 hours. After the reaction is completed, the polymerization solution is added dropwise into water to precipitate the copolymer.

[0051] 3-2 coating

[0052] Hexadecyl methacrylate, hydroxyethyl methacrylate (HEMA) and acrylic acid modified copolymer were dissolved in 80% alcohol solution to make 1% coating solution. 1g of dialysis membrane (polysulfone hollow fiber commodity. Wall thickness 40um, inner diameter 200um, pore diameter about 3nm, effective area 1.5m 2 ) soaked in 10mL of coating solution, and dried at 25°C for 24 hours.

[0053] 3-3 polylysine modi...

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Abstract

The invention discloses a modification method for a blood purification material. The modification method comprises the steps that hydrophobic alkyl methacrylate and hydroxyethyl methacrylate are mixed with vinyl pyrrolidone and phosphorylcholine-containing monomers or acrylic acid in solvent, and polymerization isinitiated to obtain random copolymers; the random copolymers are separated out and then dissolved in the solvent after unreacted monomers are removed, and coating solutions are obtained; dialysis membranes are steeped in the coating solutions and then taken out for drying after being reacted completely, and then the coating blood purification material is obtained. According to the modification method for the blood purification material, the purification material is processed through coating and the like, therefore, the hydrophilic and hydrophobic monomer ratio of the copolymers is changed, the hydrophilic and hydrophobic capacity of the coating copolymers is adjusted, the blood compatibility of the copolymers and the affinity to macromolecular toxins are improved, and the purposes of adsorbing and removing the macromolecular toxins are achieved; long-chain alkane of coating membranes and benzene ring structures of the purification material can form a firmer double-membrane structure through the hydrophobic interaction, and the double-membrane structure is not prone to falling off.

Description

technical field [0001] The invention relates to a modification method of a blood purification material. Background technique [0002] Hemodialysis is a type of blood purification technology. It uses the principle of semi-permeable membrane to introduce the patient's blood and dialysis fluid into the dialyzer at the same time, and the two flow in opposite directions on both sides of the dialysis membrane. It removes all kinds of harmful and redundant metabolic wastes and excess electrolytes from the body through diffusion to achieve the purpose of removing toxins and excessive water retention in the body, and achieving the purpose of correcting water, electrolyte and acid-base balance. [0003] The thickness of the semipermeable membrane used in hemodialysis is 10-20 microns, and the average pore size on the membrane is 3nm, so only small molecules with a molecular weight of less than 15,000 and some medium-molecular substances are allowed to pass through, while macromolecul...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D06M15/21D06M15/59C08F220/18C08F220/28C08F226/10C08F220/32C08F230/02C08F220/06A61M1/28
Inventor 姜建明李设桥
Owner 佛山市博新生物科技有限公司
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