A kind of production technology for controlling the density of chondroitin sulfate sodium

Abstract

The invention belongs to the field of medicine and particularly discloses a production technology capable of controlling the density of chondroitin sulfate sodium. The technology comprises the steps as follows: mother liquor is prepared and divided into A1, A2, B1 and B2 with equal volumes, and the temperatures of the solutions are adjusted to be 20 DEG C; the A1 and the A2 are precipitated by adding ethanol to the mother liquor, and the concentration of ethanol is adjusted to 68%-82% after precipitation of the A1; the precipitation temperature of the A2 is adjusted to the room temperature of 38-42 DEGC, and the concentration of ethanol is adjusted to 70%-80% after precipitation of A2; the B1 and the B2 are precipitated by adding ethanol to the mother liquor, and the concentration of ethanol is adjusted to 68%-82% after precipitation of the B1; the precipitation temperature of the B2 is adjusted to the room temperature of 38-42 DEGC, and the concentration of ethanol is adjusted to 70%-80% after precipitation of B2; the precipitated solutions are dehydrated, dried, crushed and sieved, and chondroitin sulfate sodium raw materials with different densities are obtained. The technology is reasonable in design, simple and convenient, the densities of the raw materials are easy to control, the cost is low, the yield rate in product preparation production is increased, and the technology is applicable to large-scale industrial production.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a production process for controlling the density of chondroitin sulfate sodium. Background technique [0002] Chondroitin sulfate (CS) is a class of glycosaminoglycans covalently attached to proteins to form proteoglycans. Chondroitin sulfate is widely distributed in the extracellular matrix and cell surface of animal tissues. The sugar chain is composed of alternating glucuronic acid and N-acetylgalactosamine (also known as N-acetylgalactosamine) disaccharide units. The linking region is linked to a serine residue of the core protein. CS is a natural acidic mucopolysaccharide, which is a biological polymer compound. CS has three isomers of A, C and D, all of which are composed of D-glucuronic acid and N-acetyl-D-galactosamine sulfate It is composed of units, but the position of the sulfuric acid group is different. CS widely exists in cartilage tissues of humans and some a...

AI Technical Summary

Problems solved by technology

[0005] The density of chondroitin sulfate sodium raw material plays a decisive role in the formulation process of tablets or capsules when it is made into dosage forms. Too large or too small density will affect the molding of dosage forms such as tablets or capsules. Therefore, the control of sulfuric acid The density of chondroitin sodium API is a key part of the preparation process, and there is no relevant technology to solve this problem

[0006] Chinese patent CN 105399864A discloses a "preparation process of high-purity and low molecular weight uranium chondroitin sulfate", Chinese patent CN103214595B discloses a "preparation method of sodium chondroitin sulfate", and Chinese patent CN103601815B discloses a "alkali hydrolysis- Enzymatic hydrolysis combined with flocculation and precipitation method to extract sodium chondroitin sulfate", the preparation process of the above patents does not involve the control of the density of sodium chondroitin sulfate

[0007] In view of the above, at present, what is urgently needed in the market is a method that can overcome the above-mentioned defects and meet the needs of different dosage forms for different densities of chondroitin sulfate sodium raw materials, so as to avoid excessive or too small densities affecting the molding of dosage forms, resulting in the production of enterprises. waste of resources

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