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Method for industrialized preparation of high-activity American ginseng polysaccharide capsule

A polysaccharide and high activity technology of American ginseng, which can be used in capsule delivery, organic active ingredients, pharmaceutical formulations, etc., and can solve problems such as environmental pollution, polysaccharide activity impact, and high cost

Inactive Publication Date: 2017-06-30
HARBIN UNIV OF COMMERCE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The traditional methods for the purification of American ginseng polysaccharides mainly include sevag method, trichloroacetic acid (TCA) method, hydrochloric acid method, enzymatic method, activated carbon adsorption method and hydrogen peroxide method, etc. A large number of organic solvents not only pollute the environment, but also have a high cost, and have a great impact on the activity of the treated polysaccharides
The enzymatic method is relatively mild, but the cost of the enzyme is very high, and it is not suitable for large-scale industrial production

Method used

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  • Method for industrialized preparation of high-activity American ginseng polysaccharide capsule

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Embodiment 1

[0038] like figure 1 As shown, the present embodiment prepares highly active American ginseng polysaccharide according to the following method:

[0039] (1) Pretreatment: select the whole root of American ginseng, pulverize it to 80 meshes, and obtain American ginseng powder for use;

[0040] (2) Extraction: The American ginseng powder is extracted with pure water in an ultrasonic extraction tank. The ultrasonic power is controlled to be 1000W, the temperature is 75°C, the ultrasonic time is 25min, and the ratio of material to liquid is 1:25 (w / w) to obtain the crude extraction of American ginseng polysaccharide. thing;

[0041] (3) Centrifugal filtration: use a centrifuge to perform solid-liquid separation on the crude polysaccharide extract of American ginseng to obtain a crude polysaccharide extract of American ginseng, and use a plate filter to filter the crude polysaccharide extract of American ginseng to obtain a crude polysaccharide extract of American ginseng;

[004...

Embodiment 2

[0047] like figure 1 As shown, the present embodiment prepares highly active American ginseng polysaccharide according to the following method:

[0048] (1) Pretreatment: select the whole root of American ginseng, pulverize it to 80 meshes, and obtain American ginseng powder for use;

[0049] (2) Extraction: The American ginseng powder is extracted with pure water in an ultrasonic extraction tank. The ultrasonic power is controlled to be 1000W, the temperature is 75°C, the ultrasonic time is 25min, and the ratio of material to liquid is 1:25 (w / w) to obtain the crude extraction of American ginseng polysaccharide. thing;

[0050] (3) Centrifugal filtration: use a centrifuge to perform solid-liquid separation on the crude polysaccharide extract of American ginseng to obtain a crude polysaccharide extract of American ginseng, and use a plate filter to filter the crude polysaccharide extract of American ginseng to obtain a crude polysaccharide extract of American ginseng;

[005...

Embodiment 3

[0056] This embodiment provides a highly active American ginseng polysaccharide capsule, the content of which is mixed with American ginseng polysaccharide extract, auxiliary material: dextrin, and wetting agent: ethanol (80%), wherein: the amount of auxiliary material added in 100 g of content is: 15g, and the amount of wetting agent added is 20mL.

[0057] The specific preparation method is as follows:

[0058] (1) Pass the American ginseng polysaccharide extract and dextrin through a 60-mesh sieve respectively, and then put them into a three-dimensional motion mixer to mix for 30 minutes to obtain a mixed powder;

[0059] (2) Using 80% ethanol solution as a wetting agent, a high-efficiency wet mixing granulator was used to form wet granules of 24 meshes. The wet granules were dried in a hot air circulation oven at a temperature of 50 °C, and a swinging granule was used after drying. 25-mesh sieve for granulation to obtain dry granules;

[0060] (3) Fill the dry granules i...

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Abstract

The invention discloses a method for industrialized preparation of a high-activity American ginseng polysaccharide capsule. The method for preparation of American ginseng polysaccharides comprises the following steps: (1) crushing American ginseng roots, to obtain an American ginseng powder; (2) extracting with purified water by using an ultrasonic extraction tank, to obtain an American ginseng polysaccharide crude extract; (3) centrifuging and filtering, to obtain an American ginseng crude polysaccharide extract liquid; (4) concentrating, and purifying by macroporous resin, to obtain an American ginseng polysaccharide eluate; (5) concentrating, and carrying out secondary purification with polyamide, to obtain a secondary purified polysaccharide eluate; (6) concentrating, carrying out alcohol precipitation, carrying out centrifugal separation, washing, and carrying out suction filtration, to obtain American ginseng polysaccharides; and (7) carrying out low temperature freeze drying, to obtain an American ginseng polysaccharide extract. The method can improve the biological activity and the stability of the American ginseng polysaccharides, has the advantages of simple preparation process and high raw material utilization rate, is suitable for industrialized production, is beneficial for development and utilization of American ginseng polysaccharide functional products, and has significant meaning for prevention and treatment of various diseases.

Description

technical field [0001] The invention belongs to the technical field of American ginseng polysaccharide processing, and relates to a preparation method of American ginseng polysaccharide capsules, in particular to a method for industrially preparing high-activity American ginseng polysaccharide capsules. Background technique [0002] American ginseng, scientific name Panax quinquefolius, English name American ginseng, is a perennial herb of Araliaceae ginseng, also known as American ginseng, American ginseng, American ginseng. my country introduced and succeeded in the early 1980s, and now it has become the world's largest producer and consumer of American ginseng. American ginseng has been successfully cultivated in many provinces in China, among which the three northeastern provinces, Qinba Mountains in Shaanxi, Shandong, Huairou in Beijing and Changbai Mountain are widely cultivated. The main chemical components of American ginseng include saponins, polysaccharides, amino...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61K31/715A61K9/48A61K47/36C08B37/00
Inventor 刘颖于晓红窦博鑫
Owner HARBIN UNIV OF COMMERCE
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