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A hydroxypropionic acid compound and its preparation method and medical application

A technology of hydroxypropionic acid and compounds, applied in the field of medicine, to achieve the effects of convenient and easy-to-obtain raw material sources, favorable industrialization, and simple preparation steps

Inactive Publication Date: 2019-10-08
DALI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Except that the inventor of this patent has conducted a preliminary study on the anti-tumor and antibacterial effects of its crude extract in the early stage, there have been no other reports about the extract and its use

Method used

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  • A hydroxypropionic acid compound and its preparation method and medical application
  • A hydroxypropionic acid compound and its preparation method and medical application
  • A hydroxypropionic acid compound and its preparation method and medical application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 :The preparation and structure identification of the compound of formula (I)

[0024] 1.1 Experimental equipment and materials

[0025] NMR spectrum was measured by Bruker AV-400 nuclear magnetic resonance spectrometer (δ is ppm, TMS is internal standard, J is Hz); MS spectrum is measured by Agilent G3250AA LC / MSD TOF electrospray time-of-flight mass spectrometer; Rotary evaporator uses Heidolph, Germany; the circulating condensate pump adopts Japan's EYELA; the analytical balance adopts the pioneer manufactured by Ohaus Instrument (Shanghai) Co., Ltd. Sephadex (Pharmadex LH-20) for column chromatography was purchased from Amphamacia Biotechnology (China) Co., Ltd.; ODS reversed-phase materials were purchased from Merck; column-layer silica gel and thin-layer chromatography silica gel plates were Produced by Qingdao Ocean Chemical Plant. The elution solvents for chromatography are industrially pure solvents or chemically pure solvents that have been re-evaporated...

Embodiment 2

[0039] Example 2 :Detection of the ability of compounds of formula (I) to scavenge 1,1-diphenyl-dipicrylhydrazine (DPPH) free radicals

[0040] 2.1 Experimental principle and experimental purpose

[0041] DPPH is a relatively stable lipid free radical, with a free electron on its N, and its ethanol solution is purple. Scanning at the full wavelength shows that it has a maximum absorption peak at 517nm. After adding antioxidants, DPPH captures an electron to pair with free electrons, the purple fades and becomes a colorless substance, and the absorption peak at 517nm disappears. The degree of fading has a quantitative relationship with the number of electrons it accepts. That is, the absorption value of DPPH decreases when it is redox, and the lower the absorbance, the stronger its antioxidant effect. According to this principle, the ability of the sample to provide hydrogen atoms, scavenge free radicals, and resist oxidation can be measured.

[0042] 2.2 Methods and results

[0...

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PUM

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Abstract

The invention relates to a hydroxypropionic acid compound and a preparation method thereof and a medical application, in particular to a (S)-2-hydroxypropionic acid-(3,4-dihydroxy phenyl) ethyl ester compound separated from medicinal blaps rynchopetera fairmaire, an extraction, separation and preparation method of the compound and an medical application of the compound to preparation of antioxidants. The compound has biological activities remarkably removing DPPH (1,1-diphenyl-2-picryhydrazyl), IC50 value of the compound removing the DPPH is 9.99+-1.61 microgrammes / milliliters and is equivalent to positive control vitamin C (IC50 value is 6.92+-0.89 microgrammes / milliliters). The compound shown as the formula (I) has novelty and great potential developing into novel antioxidants and can be expectedly developed into the antioxidants preventing and treating physiological changes or diseases related to free radicals.

Description

Technical field [0001] The invention relates to the field of medical technology. Specifically, the present invention relates to a hydroxypropionic acid compound isolated from the beetle of a medicinal insect, a hydroxypropionic acid compound, and a preparation method and medical use thereof. The compound has the activity of scavenging DPPH (1,1-diphenyl-2-picryl-hydrazyl) free radicals, and can be expected to develop into an antioxidant that prevents physiological changes or diseases related to free radicals. Background technique [0002] Free radicals are active molecules produced by the human body during life activities. Under normal circumstances, the body's antioxidant defense system can scavenge free radicals to maintain a balance between production and elimination. When the production and removal of free radicals is out of balance, it will cause body damage, induce various diseases, and accelerate aging. Free radicals can cause a variety of human diseases: oxidative damag...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C69/675C07C67/48A61K31/222A61P39/06A61P1/16A61P25/28A61P9/00A61P17/18A61P3/10
Inventor 肖怀郭娜娜洪杏芳罗晴巫秀美施贵荣刘光明
Owner DALI UNIV