Application of coptisine in preparing medicine for preventing and/or treatingSLE (systemic lupus erythematosus) and complications of SLE
A systemic technology for lupus erythematosus, applied in the field of medicine, can solve the problems of systemic lupus erythematosus and its complications, etc. which are not found in coptisine, and can reduce the deposition of immune complexes, protect the vascular endothelial function, and alleviate the pathological process. Effect
Inactive Publication Date: 2017-07-07
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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So far, we have not found reports related to systemic lupus erythematosus and its complications and the use of coptisine in the preparation of related products
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Embodiment 1
[0035]Example 1: Establishment of mouse model of systemic lupus erythematosus.
[0036] Pristane is an organic alkane substance extracted from mineral oil, which can cause immune disorders, thereby inducing lupus-like symptoms in mice. In this example, the systemic lupus erythematosus model in mice was induced by intraperitoneal injection of pristane, and animal autoantibodies, serum inflammatory factors, renal function and renal tissue morphology changes, spleen tissue morphology changes, blood pressure and vascular activity were determined to determine the effect of coptisine on mice. Systemic lupus erythematosus and its role in the prevention and treatment of cardiovascular disease.
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The invention discloses application of coptisine shown as general formula (I) as shown in the specification and pharmaceutically acceptable salt of the coptisine in preparing a medicine for preventing and / or treatingSLE (systemic lupus erythematosus) and complications of SLE.The application has the benefits that the coptisine has pharmacological actions of reducing an in-vivo autoantibody expression level of a mouse with lupus, improving an immunologic function, reducing immune complex sedimentation in a kidney tissue of the mouse with the lupus and improving a kidney function of the mouse with the lupus, and effects of protecting a spleen function of the mouse with the lupus, protecting a vascular endothelium function of the mouse with the lupus, reducing blood pressure and improving vascular activity of the mouse with the lupus.The coptisine is a monomeric compound extracted from a common traditional Chinese medicine, namely rhizoma coptidis, has the advantages of low toxicity, simple extraction technology and the like, is wide in raw material resource, has good application and development prospects and is a relatively perfect novel traditional Chinese medicine monomer for treating the SLE, and the complications of the SLE such as immune dysfunction, lupus nephritis, lupus spleen injury, lupus atherosclerosis and lupus hypertension.
Description
technical field [0001] The invention relates to the new pharmacological action of the traditional Chinese medicine berberine and the application of berberine to prevent and / or treat systemic lupus erythematosus and its complications, belonging to the technical field of medicine. [0002] technical background [0003] Systemic lupus erythematosus (SLE) is a chronic multisystem recurrent autoimmune disease, its main pathological features are the production of autoantibodies and the deposition of immune complexes, the clinical manifestations are complex and diverse, the disease is protracted and repeated, almost All vital organs (eg, heart, kidneys, and lungs) and tissues (eg, skin, joints, and serosa) are affected. In addition, the blood system and central nervous system are often the main parts of the body in patients with systemic lupus erythematosus. According to the statistics of the American Lupus Foundation, there are no less than 1.5 million patients with systemic lupus...
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Login to view more IPC IPC(8): A61K31/4375A61P19/04A61P37/00A61P13/12A61P9/10A61P9/12A61P1/00A23L33/105
CPCA01N65/32A23V2002/00A61K31/4375A23V2200/306A23V2200/324A23V2200/326A23V2250/21
Inventor 方莲花秦海林杜冠华张志辉袁天翊阎雨何阳阳陈俞材
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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