Calcium sulfate hemihydrate/ octacalcium phosphate/ carboxymethyl chitosan composite artificial bone material and preparation method thereof

A technology of carboxymethyl chitosan and calcium sulfate hemihydrate, which is applied in the fields of pharmaceutical formula, medical science, prosthesis, etc., can solve the problems of incomplete degradation, affecting new bone ingrowth, and long time in the body. Achieve the effects of good mechanical strength, good injectability and good biocompatibility

Inactive Publication Date: 2017-07-11
WUHAN UNIMEDICAL TECH
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  • Abstract
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Problems solved by technology

However, the calcium sulfate artificial bone material degrades and absorbs too quickly in the human body, faster than the formation of new bone, so it is not suitable for repairing large bone defects and bone defects with a long healing time; and the injectable calcium phosphate artificial bone is also It is called injectable calcium phosphate bone cement, which degrades slowly in the human body and stays in the body for too long, which cannot meet the requirement of complete degradation after new bone formation, which affects the growth of new bone and makes its application subject to certain restrictions. limit

Method used

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  • Calcium sulfate hemihydrate/ octacalcium phosphate/ carboxymethyl chitosan composite artificial bone material and preparation method thereof
  • Calcium sulfate hemihydrate/ octacalcium phosphate/ carboxymethyl chitosan composite artificial bone material and preparation method thereof

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preparation example Construction

[0029] Preparation of calcium sulfate hemihydrate: Using analytically pure calcium sulfate dihydrate as raw material, calcium sulfate hemihydrate is prepared by steam heating method. First, a certain amount of calcium sulfate dihydrate is added to a stainless steel container, and then the corresponding amount has been prepared. A good crystal-transforming agent solution, stirred evenly, reacted in a closed high-temperature and high-pressure reactor under the pressure of 0.15-0.2MPa and 125-135°C, took it out after 4-6 hours, and then put it in and set the temperature at 125-135°C Dry in an oven at ℃, and finally take out, grind and sieve to obtain calcium sulfate hemihydrate powder.

[0030] Preparation of octacalcium phosphate powder

[0031] Prepare calcium acetate solution with a concentration of 0.04M and sodium dihydrogen phosphate solution with a concentration of 0.04M, then slowly add the prepared calcium acetate solution into the sodium dihydrogen phosphate solution in...

Embodiment 1

[0037]Mix 2g of α-calcium sulfate hemihydrate (CSH) with a particle size of less than 100 μm with 0.5 g of octacalcium phosphate and 0.05 g of carboxymethyl chitosan to obtain composite powder A; prepare 0.1 wt % of oxidized Sodium alginate solution, the ratio of oxidized sodium alginate solution to composite powder A is 0.5ml / g.

[0038] When in use, mix the solidified liquid and the composite powder A uniformly for 0.5-1 min, and inject it into the bone defect site.

[0039] According to the experiment: the artificial bone material can be initially fixed in 2-3 minutes to prevent its loss, and then the artificial bone material is completely cured in 5-30 minutes. After testing, the compressive strength of the fully cured composite artificial bone material is 4.35Mpa.

[0040] Test experiment of compressive strength of artificial bone material: the composite artificial bone material of calcium sulfate hemihydrate / octacalcium phosphate / carboxymethyl chitosan solidified in a cy...

Embodiment 2

[0042] After mixing 2g of α-calcium sulfate hemihydrate (CSH) with a particle size of less than 80 μm, 1 g of octacalcium phosphate with a particle size of less than 100 μm, and 0.06 g of carboxymethyl chitosan to obtain composite powder A, prepare 0.1 wt % oxidized Konjac solution, the ratio of oxidized konjac solution to composite powder A is 0.4ml / g, to obtain the required artificial bone material. The compressive strength of the final composite artificial bone material test is 6.56Mpa.

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Abstract

The invention discloses a calcium sulfate hemihydrate / octacalcium phosphate / carboxymethyl chitosan composite artificial bone material and a preparation method thereof. An injectable composite artificial bone material comprises a curing liquid and calcium sulfate hemihydrate / octacalcium phosphate / carboxymethyl chitosan composite powder, the curing liquid and the calcium sulfate hemihydrate / octacalcium phosphate / carboxymethyl chitosan composite powder are stored separately, the mass ratio of calcium sulfate hemihydrates to octacalcium phosphate to carboxymethyl chitosan is 1:0.01-0.5:0.01-0.1, the volume mass ratio of curing liquid to calcium sulfate hemihydrate / octacalcium phosphate / carboxymethyl chitosan composite powder is 0.3-1.0:1ml / g; and the curing liquid is an oxidized polysaccharide solution. Compared with various artificial bone materials in the prior art, the calcium sulfate hemihydrate / octacalcium phosphate / carboxymethyl chitosan composite artificial bone material has the advantages of simple preparation process, easy operation, good injection property and controllable composite material components, by compounding of traditional inorganic bone materials and a natural polymer material, defect part loss of in artificial bone injection initial stage can be prevented, and the calcium sulfate hemihydrate / octacalcium phosphate / carboxymethyl chitosan composite artificial bone material has the advantages of good mechanical strength, good biocompatibility and osteogenic properties, and controlled degradation.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to a human body hard tissue defect filling and repairing material, in particular to a calcium sulfate hemihydrate / octacalcium phosphate / carboxymethyl chitosan composite artificial bone material and a preparation method thereof. Background technique [0002] Bone defects have always been a difficult problem in orthopedic medicine. In recent years, with the development of minimally invasive surgery, injectable artificial bone materials have attracted more and more attention from researchers from various countries, and have become a research hotspot in biomedical materials today. Injectable calcium sulfate artificial bone material and calcium phosphate artificial bone material are the most common calcium-phosphate inorganic system materials. The materials are easy to operate and have good biocompatibility. When injected into bone defects, they can be cured in situ and adapt to Bone d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/12A61L27/02A61L27/50A61L27/58A61L27/54C08J3/24C08L5/08C08L5/04C08L1/28
CPCA61L27/025A61L27/12A61L27/20A61L27/50A61L27/54A61L27/58A61L2300/232A61L2300/404A61L2300/412A61L2400/06A61L2430/02C08J3/246C08J2305/08C08J2401/28C08J2405/02C08J2405/04C08L5/08C08L5/04C08L5/02C08L1/286
Inventor 樊李红彭敏彭锴胡祥朱晨
Owner WUHAN UNIMEDICAL TECH
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