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Zein-lecithin-curcumin composite colloidal particle and preparation thereof

A technology of zein and colloidal particles, which is applied in the functions of food ingredients, food forming, food science, etc., can solve the problems of limited application and sensitivity, and achieve the effects of easy operation, simple process and improved bioavailability

Inactive Publication Date: 2017-07-14
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, a single zein colloidal particle is sensitive to heat, pH and salt solution, which greatly limits its application as an active ingredient carrier.
However, there is no report on the preparation of composite colloidal particles from zein and lecithin to entrap curcumin

Method used

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  • Zein-lecithin-curcumin composite colloidal particle and preparation thereof
  • Zein-lecithin-curcumin composite colloidal particle and preparation thereof
  • Zein-lecithin-curcumin composite colloidal particle and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] (1) Dissolve 200 mg of zein and 50 mg of lecithin in 100 mL of 60% aqueous ethanol, and stir until completely dissolved to obtain an aqueous ethanol solution of zein and lecithin;

[0041] (2) Add 5 mg of curcumin to the ethanol aqueous solution of zein and lecithin prepared in step (1), and completely dissolve to obtain the ethanol aqueous solution of zein-lecithin-curcumin;

[0042] (3) The aqueous ethanol solution of zein-lecithin-curcumin obtained in step (2) is injected into 200mL water according to the speed of 2.5mL / min to obtain the dispersion of zein-lecithin-curcumin composite colloidal particles liquid;

[0043] (4) Put the zein-lecithin-curcumin composite colloidal particle dispersion liquid prepared in step (3) in a vacuum rotary evaporator with a vacuum degree of 0.05MPa, a temperature of 40°C, and a rotational speed of 200r / min Remove ethanol and part of the water, concentrate the dispersion by 2.5 times, centrifuge at 3000rpm for 20min to remove large p...

Embodiment 2

[0057] (1) 100 mg of zein and 50 mg of lecithin were dissolved in 100 mL of 70% aqueous ethanol and stirred until completely dissolved to obtain an aqueous ethanol solution of zein and lecithin;

[0058] (2) Add 10 mg of curcumin to the aqueous ethanol solution of zein and lecithin prepared in step (1), and completely dissolve to obtain the aqueous ethanol solution of zein-lecithin-curcumin;

[0059] (3) The ethanol aqueous solution of zein-lecithin-curcumin obtained in step (2) is injected into 300mL water according to the speed of 4mL / min, obtains zein-lecithin-curcumin composite colloid particle dispersion ;

[0060] (4) Put the zein-lecithin-curcumin composite colloid particle dispersion prepared in step (3) in a vacuum rotary evaporator with a vacuum degree of 0.01MPa, a temperature of 45°C, and a rotational speed of 300r / min Remove ethanol and part of the water, concentrate the volume of the dispersion by 4 times, and centrifuge at 3000rpm for 20min to remove large part...

Embodiment 3

[0067] (1) 100 mg of zein and 100 mg of lecithin were dissolved in 100 mL of 80% aqueous ethanol, and stirred until completely dissolved to obtain an aqueous ethanol solution of zein and lecithin;

[0068] (2) Add 20 mg of curcumin to the ethanol aqueous solution of zein and lecithin prepared in step (1), and completely dissolve to obtain the ethanol aqueous solution of zein-lecithin-curcumin;

[0069] (3) The aqueous ethanol solution of zein-lecithin-curcumin obtained in step (2) is injected into 500mL water according to the speed of 4.5mL / min to obtain the dispersion of zein-lecithin-curcumin composite colloidal particles liquid;

[0070] (4) Put the zein-lecithin-curcumin composite colloidal particle dispersion prepared in step (3) in a vacuum rotary evaporator with a vacuum degree of 0.01MPa, a temperature of 50°C, and a rotational speed of 400r / min Remove ethanol and part of the water, concentrate the dispersion to 6 times in volume, and centrifuge at 3000rpm for 20 minu...

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Abstract

The invention belongs to the technical field of functional food processing, and specifically relates to a zein-lecithin-curcumin composite colloidal particle and preparation thereof. According to the alcohol solubility and self assembly characteristic of zein and lecithin, the zein-lecithin-curcumin composite colloidal particle is prepared by an anti-solvent co-precipitation method. The technology of the method is simple, and is easy to operate. The particle size distribution of the obtained zein-lecithin-curcumin composite colloidal particle is uniform, the curcumin embedding rate can reach 99%, the curcumin bioavailability is increased, moreover, the physical stability and light-thermal stability of curcumin are both greatly improved, and a novel method is provided for stabilizing functional factors.

Description

technical field [0001] The invention belongs to the technical field of functional food processing, and in particular relates to a zein-lecithin-curcumin composite colloid particle and its preparation. Background technique [0002] Curcumin (Curcumin) is a natural active ingredient extracted from the rhizome of Turmeric, a plant of the genus Curcuma longa in the family Zingiberaceae. In addition to being used as a natural food coloring agent, Curcumin also has antioxidant, anti-inflammatory, anti-tumor (colon cancer, twelve Intestinal cancer and rectal cancer, etc.), scavenging free radicals and other biological activities. However, curcumin has low solubility in water, poor bioavailability, and is unstable. It is easily degraded by factors such as light and heat, which greatly limits its application in the food industry. In recent years, natural active substance carriers with non-toxic, good biocompatibility, biodegradability and sustained release effect have attracted more...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/115A23L33/105A23L33/185A23P10/30A23P10/35A23L2/52A23L2/66
CPCA23L2/52A23L2/66A23V2002/00A23V2200/224A23V2200/30A23V2250/1842A23V2250/2112A23V2250/548
Inventor 高彦祥代蕾孙翠霞
Owner CHINA AGRI UNIV
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