A kind of liposome freeze-dried composition and application

A liposome freeze-drying and composition technology, which is applied in cosmetic liposomes and cosmetics fields, can solve the problems of not considering the shape of the final product, failing to maintain the fine structure, and difficult to form the appearance, so as to achieve fine appearance, maintain the fine structure, Strong appearance effect

Active Publication Date: 2020-12-11
上海鲜可生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing technology does not consider the shape of the final product, and it is difficult to form a geometric figure with a fine appearance, good texture, and solid appearance, let alone maintain a fine structure, such as a simulated flower shape

Method used

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  • A kind of liposome freeze-dried composition and application
  • A kind of liposome freeze-dried composition and application
  • A kind of liposome freeze-dried composition and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment one: the preparation method of propylene glycol alginate liposome freeze-dried composition

[0044](1) Weigh 8-588 parts of propylene glycol alginate liposome, 24-533 parts of thickener, and 133-930 parts of filler, add to water, fully swell, and mix well.

[0045] (2) Transfer the liquid obtained in step (1) to a mold, freeze until completely solidified, and demould to obtain a frozen geometric figure.

[0046] (3) Transfer the frozen geometric figure obtained in step (2) to the sublimation chamber of the freeze-drying equipment, and sublimate under reduced pressure until the drying is complete.

[0047] Liposome stability comparison in liquid state: take each liposome suspension, measure the original average particle size P1; The sample after incubation was 2 mL, and the average particle size P2 after incubation was measured; the particle size increase rate was calculated = (P2-P1) / P1*100%, and the larger the value, the worse the stability.

[0048] Compa...

Embodiment 2

[0052] Embodiment two: the liquid stability and freeze-dried stability comparison of different liposomes

[0053] Sample 1, propylene glycol alginate liposome (PGA liposome): (1) Weigh 1 g of hydrogenated lecithin, dissolve it completely in 18 ml of ether and 2 ml of chloroform, and it is an oil phase; weigh 0.1 g of propylene glycol alginate, In 99.9g of water (0.1% propylene glycol alginate aqueous solution), heat and swell to form the water phase; (2) take 10g of the water phase (containing 0.1% propylene glycol alginate) and slowly add it to the oil phase, ultrasonically, to obtain W / O Emulsion; (3) Add 90g of water phase to the W / O suspension in (2), ultrasonicate for 5min to obtain W / O / W emulsion; (4) Remove the organic solvent by rotary evaporation, add water to 100ml, pass through 0.22um filter membrane to obtain the suspension of propylene glycol alginate liposome.

[0054] Sample 2, blank liposome + external water phase propylene glycol alginate (blank liposome + ex...

Embodiment 3

[0066] Embodiment 3: Structural toughness and texture comparison of different liposome freeze-dried compositions

[0067] Table 2: Formulation table of four different components

[0068]

[0069] Weigh 8g of hydrogenated lecithin, add absolute ethanol, heat and dissolve completely, and become the oil phase; weigh 2g of propylene glycol alginate, dissolve it in 998g of water (0.2% propylene glycol alginate), and swell it to become the water phase; the oil phase is rotary evaporated Remove ethanol to form a thin film; add 1000 g of water phase, and ultrasonicate for 5 minutes to obtain a suspension of PGA liposomes with a solid content of about 1%.

[0070] Formula 1, the formula of the present invention: take by weighing liposome suspension 250g (equivalent to liposome 2.5g), thickener, filler three kinds of components, mix, add water to be settled to 400ml water, stir to swell Completely; fill rose silicone molds, freeze completely at -30°C, take out the mold; transfer the...

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Abstract

The invention provides a lipidosome freeze-drying composition, which is formed by freeze drying of propylene glycol alginate lipidosome and at least one thickening agent and at least one filling agent. The propylene glycol alginate is coated by a membrane material in an internal water phase, thus improving stability of the lipidosome; meanwhile, the thickening agent is compounded to form the skeleton of the freeze-drying composition, and the filling agent is compounded to increase the density of the freeze-drying composition, so that the whole structure is stronger. Meanwhile, the lipidosome membrane material itself is a lipoid component, so that the freeze-drying composition is finer and is improved in toughness. The three components are subjected to freeze drying shaping, so that not only is the microstructure of the lipidosome maintained, but also shaping of a fine structure, such as flowers and the like, can be supported. The composition, when being redissolved in water, has excellent skin care function, and has excellent enjoyment during application. The freeze-drying composition is a creative combination and application form, and has important practical significance in the field of cosmetics.

Description

technical field [0001] The present invention mainly relates to the technical field of cosmetics, in particular, the present invention relates to the technical field of cosmetic liposomes. Background technique [0002] Liposome (Lipsomes) is a closed vesicle-like structure containing an aqueous phase inside, and the wall of the vesicle is composed of a bimolecular membrane. The capsule wall is composed of lipophilic and hydrophilic amphiphilic molecules. The lipophilic tail part is located in the middle of the membrane, while the hydrophilic head part forms the inner and outer surfaces of the membrane. This property makes fat-soluble and water-soluble Drugs can be encapsulated by liposomes. Lipophilic functional ingredients are generally contained in the bilayer, and hydrophilic functional ingredients are generally contained in the inner water phase, so liposomes have a wide range of applications for loading functional substances. [0003] Liposome has excellent biomembrane...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A61K8/14A61K8/73A61Q19/00
CPCA61K8/14A61K8/733A61K2800/10A61Q19/00
Inventor 侯沛卢玲巧
Owner 上海鲜可生物技术有限公司
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