Plant extract-containing compound polypeptide liposome composition and preparation method thereof, as well as application of composition in wrinkle reduction product

A technology of plant extracts and compositions, applied in the field of personal care products, can solve problems such as unpredictability, and achieve the effect of promoting molecular activity and improving elasticity

Active Publication Date: 2017-07-21
东莞华工创为生物科技有限公司
View PDF4 Cites 13 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, the active ingredients in beauty products and personal care products are mainly added by simply mixing with the matrix. Since the skin has a protective barrier function, the active ingredients in the product can only be absorbed by the skin to a limited extent, so the expected effect cannot be achieved. , Liposome is a small capsule with a structure similar to that of a biological membrane. It is similar to the phospholipid bilayer molecules of the stratum corneum of the skin. Using liposomes to wrap active ingredients can promote the penetration of active ingredients into the skin. , improve the utilization rate, and at the same time, the use of liposomes can prevent the deterioration of active ingredients, increase the stability of active ingredients, and extend the shelf life. At present, liposomes are mainly used as delivery media to concentrate drug carriers. relatively little use of

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Plant extract-containing compound polypeptide liposome composition and preparation method thereof, as well as application of composition in wrinkle reduction product
  • Plant extract-containing compound polypeptide liposome composition and preparation method thereof, as well as application of composition in wrinkle reduction product
  • Plant extract-containing compound polypeptide liposome composition and preparation method thereof, as well as application of composition in wrinkle reduction product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Add 5 grams of dipalmitoyl lecithin and 5 grams of cholesterol into 20 mL of ethanol, disperse and dissolve evenly, and obtain a lipid solution;

[0045]Add 1 g of peach flower extract, 0.5 g of angelica extract, 0.5 g of nard pine extract, 0.1 g of acetyl hexapeptide-8 and 0.1 g of palmitoyl tripeptide-5 to 150 g of Disperse and dissolve evenly in a phosphate buffer solution with a concentration of 2%; place it in a water bath at a stirring speed of 100rpm and 40°C, slowly inject the lipid solution, and keep stirring under the same conditions for 0.5 hours after the injection is completed; Sonicate in a water bath for 1 minute, and pass through a microporous membrane to obtain a complex polypeptide liposome composition containing plant extracts.

Embodiment 2

[0047] Add 5 grams of phosphatidylcholine, 7 grams of cholesterol, and 8 grams of dipalmitoyl lecithin into a mixed solvent of 26 mL of ethanol and glycerol (v / v=1:1), disperse and dissolve evenly, and obtain a lipid solution;

[0048] Add 1 g of peach flower extract, 3 g of angelica extract, 2 g of nard pine extract, 0.2 g of acetyl hexapeptide-8, and 0.1 g of palmitoyl tripeptide-5 into a mixture containing 2 g of Tween 80 and 2 g of In 150 grams of 2.5% phosphate buffer solution of Span 80, it is uniformly dispersed and dissolved; it is placed in a water bath with a stirring speed of 200rpm and 40°C, and the lipid solution is slowly injected. After the injection is completed, keep the same conditions Stir continuously for 1 hour; sonicate in an ice-water bath for 1 minute, and pass through a microporous membrane to obtain a complex polypeptide liposome composition containing plant extracts.

Embodiment 3

[0050] Add 12 grams of cholesterol and 12 grams of soybean lecithin into 30 mL of a mixed solvent of ethanol and 1,3-butanediol (v / v=1:1), disperse and dissolve evenly, and obtain a lipid solution;

[0051] Add 5 g of peach flower extract, 8 g of angelica extract, 7 g of nard pine extract, 0.2 g of acetyl hexapeptide-8, 0.2 g of palmitoyl tripeptide-5 and 0.2 g of palmitoyl pentapeptide-3 into Containing 150 grams of Tween 80 and 2 grams of Tween 80 in 150 grams of 3% phosphate buffered saline solution, dispersed and dissolved evenly; it was placed in a water bath with a stirring speed of 200 rpm and 40 ° C, and the lipid solution was slowly Injection, after the injection is completed, maintain the same conditions and continue to stir for 1 hour; ice-water bath ultrasonic for 3 minutes, pass through a microporous membrane to obtain a complex polypeptide liposome composition containing plant extracts.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention belongs to the technical field of personal nursing products, and discloses a plant extract-containing compound polypeptide liposome composition and a preparation method thereof, as well as application of the composition in a wrinkle reduction product. The composition is prepared from the following components in percentage by weight: 1 to 15 percent of a plant extract, 0.1 to 0.5 percent of composite small-molecule active polypeptides, 5 to 20 percent of lipid, 1 to 3 percent of an emulsifier, 50 to 75 percent of a buffer solution and 10 to 20 percent of a solvent, wherein the plant extract is at least one of a peach flower extract, an angelica sinensis extract and a rhizoma nerdostachyos extract; and the composite small-molecule active polypeptides are selected from at least one of argireline acetate-8, acetyl glutamine heptapeptide-3, acetyl octaeptide-1, palmitoyl hexapeptide-19, palmitoyl oligopeptide, palmitoyl tripeptide-5 and palmitoyl pentapeptide-3. By the use of the synergistic effect of effective components of various extracts and polypeptide molecules, the molecular activity is promoted, the elasticity of the skin is obviously improved, and the plant extract-containing compound polypeptide liposome composition can be applied to the wrinkle reduction product.

Description

technical field [0001] The invention belongs to the technical field of personal care products, and in particular relates to a complex polypeptide liposome composition containing plant extracts, a preparation method thereof and an application in anti-wrinkle products. Background technique [0002] Skin wrinkles are an obvious sign and manifestation of skin aging, and are the result of the joint action of endogenous and exogenous factors. Among them, exogenous factors include the production of active oxygen free radicals due to exposure to environmental factors such as sunlight and environmental pollutants, which directly damage the DNA of skin cells and the collagen, elastin or mucopolysaccharide molecules of the extracellular matrix, resulting in thinning of the skin, epidermis The weakening of the interweaving with the dermis and the decrease in the number of cells and blood vessels will lead to facial wrinkles; due to stress, emotions and other reasons, the skin's regulati...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K8/64A61K8/14A61K8/55A61Q19/08
CPCA61K8/14A61K8/553A61K8/64A61K8/97A61Q19/08
Inventor 张继勇程建华何衍健彭华勇陈柔羲郑华生谢培镇张鹏
Owner 东莞华工创为生物科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products