Chitosan composite dressing and preparation method thereof

A chitosan, consistent technology, applied in the field of chitosan composite dressing and its preparation, can solve problems such as insufficient liquid absorption, and achieve the effects of avoiding whitening and swelling, promoting self-coagulation, and high permeability

Active Publication Date: 2017-07-21
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The composite dressing uses an electrospinning method to prepare a chitosan cushion layer, and arranges vent holes on the chitosan cushion layer, and adds a layer of medical water-absorbing cushion layer and waterproof material between the chitosan cushion layer and the medical adhesive tape. Layer, the medical absorbent pad can increase the liquid absorption, and the waterproof layer prevents excessive body fluids from penetrating into the medical tape, solving the problems of the existing chitosan dressings such as air permeability and insufficient liquid absorption

Method used

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  • Chitosan composite dressing and preparation method thereof
  • Chitosan composite dressing and preparation method thereof
  • Chitosan composite dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Such as figure 1 Shown, a kind of chitosan composite dressing comprises chitosan application cushion layer 2, medical absorbent cushion layer 3, waterproof layer 4, medical adhesive tape adhesive layer 5, waterproof layer 4 is covered on the medical adhesive tape adhesive layer 5, and medical absorbent absorbent layer The cushion layer 3 is located between the chitosan cushion layer 2 and the waterproof layer 4. The chitosan cushion layer 2, the medical absorbent cushion layer 3 and the waterproof layer 4 have the same shape and area, and the chitosan cushion layer 2 is covered with a Layer release paper 1, the area is consistent with medical adhesive tape sticking layer 5.

[0034] The area of ​​the chitosan pad layer 2 is smaller than the adhesive layer 5 of medical tape.

[0035] The chitosan pad layer 2 is provided with air vent a, which can increase the air permeability of the dressing, and is oval in shape, and the unique oval design can relieve skin irritation; ...

Embodiment 2

[0044] Step A: Prepare chitosan into a mixed solution with a mass percentage of 3%, the solvent is a mixed solution with a mass percentage of purified water and glycerol of 1:1, stir evenly, and stand for 28 hours to obtain a spinning stock solution ,spare;

[0045] Step B: Under the environment of temperature 25°C and humidity 45%, electrospin the spinning dope, adjust the speed of the micro injection pump to 0.1mL / h, adjust the voltage of the high voltage generator to 18KV, and adjust the speed of the receiving drum The receiving distance is 12cm. By using the power unit to control the horizontal movement and rotation of the receiving drum, the horizontal moving speed of the receiving drum is 0.001mm / s, and the rotating speed of the receiving drum is set to 1000r / s during spinning. sugar spun fibers;

[0046] Step C: soak the chitosan spun fiber in a concentration of 1.0% CaCl 2 Carry out cross-linking in the ethanol solution of cross-linking, after cross-linking 0.5 hour,...

Embodiment 3

[0052] Step A: Prepare chitosan into a mixed solution with a mass percentage of 6%, the solvent is a mixed solution with a mass percentage of purified water and glycerol of 2:1, stir evenly, and stand for 28 hours to obtain a spinning stock solution ,spare;

[0053] Step B: Under the condition of temperature of 25°C and humidity of 45%, electrospinning the spinning stock solution, adjusting the speed of the micro injection pump to 0.1mL / h, adjusting the voltage of the high voltage generator to 15KV, and adjusting the speed of the receiving drum The receiving distance is 15cm. By using the power unit to control the horizontal movement and rotation of the receiving drum, the horizontal moving speed of the receiving drum is 0.002mm / s, and the rotating speed of the receiving drum is set to 2500r / s during spinning. sugar spun fibers;

[0054] Step C: soak the chitosan spun fiber in a concentration of 3.0% CaCl 2 Carry out cross-linking in the ethanol solution of cross-linking, af...

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Abstract

The invention discloses a chitosan composite dressing and a preparation method thereof. The composite dressing comprises a chitosan dressing base layer, a medical water absorbing base layer, a waterproof layer and a medical adhesive tape adhesion layer, wherein the waterproof layer covers the medical adhesive tape adhesion layer; the medical water absorbing base layer is positioned between the chitosan dressing base layer and the waterproof layer; air holes are formed in the chitosan dressing base layer; the shapes and the areas of the chitosan dressing base layer, the medical water absorbing base layer and the waterproof layer are the same; anti-adhesion paper covers the chitosan dressing base layer; and the area of the anti-adhesion paper is consistent to that of the medical adhesive tape adhesion layer. The air holes on the chitosan dressing base layer and the medical water absorbing base layer can guarantee high permeability of water and air, and a wound is prevented from turning white and swelling. The medical water absorbing base layer has a water absorbing pad structure with high water absorption capability, tissue exudate penetrates through the air holes and is absorbed by the water absorbing pad, and efficient liquid absorption property is achieved. The waterproof layer can prevent excessive body fluid from permeating onto a medical adhesive tape, a part covered by the dressing can be fixed well, and the dressing cannot drop easily.

Description

technical field [0001] The patent of the invention relates to a medical wound dressing, in particular to a chitosan composite dressing and a preparation method thereof. Background technique [0002] With the development of society, clinical and war wound treatment have higher and higher requirements for local trauma hemostasis. Compared with traditional dressings, biological dressings have better compatibility, less toxic and side effects, low antigenicity, certain water permeability, and It has the advantages of reducing the frequency of wound dressing changes and improving the quality of wound healing. Biomedical materials are considered to be one of the most effective materials for local trauma hemostasis. Chitosan is a natural polymer derived from a wide range of deacetylated chitin. It has good biocompatibility and hemostatic effect, and can prevent the formation of fibrin, the proliferation of connective tissue cells and the synthesis of collagen. It has biological p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/42A61L15/26A61L15/58A61L15/46A61L15/44A61F13/02
CPCA61F13/00063A61F13/00068A61F13/0209A61F13/0253A61F13/0289A61L15/26A61L15/28A61L15/42A61L15/44A61L15/46A61L15/58A61L2300/404A61L2300/41A61L2300/412A61L2300/418A61L2400/04C08L5/08C08L67/00
Inventor 车七石
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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