Microfluidic chip, production method and in-situ catalysis and detection method thereof

Abstract

The present application discloses a microfluidic chip, a production method and an in-situ catalysis and detection method thereof, wherein a periodic peak microstructure is processed inside a silicon-based Y type channel. According to the present invention, after the black silicon surface is subjected to hydrogenation treatment with hydrofluoric acid, the in-situ chemical growth of silver nanoparticles on the peak microstructure surface can be achieved, such that the catalytic reaction efficiency and the reaction activity of the reduction of p-nitrophenol into p-aminophenol are improved by using the large specific surface area and the roughness of the Ag-black silicon composite structure (Ag-BS); the surface plasma resonance motif is easily formed with the Ag-BS composite structure so as to be used for surface-enhanced Raman scattering (SERS) detection; and the Ag-BS micro-nano-structure composite device has wide application prospects in highly integrated chemical synthesis, analysis, biosensing, diagnosis and other fields.

Description

technical field [0001] The application belongs to the technical field of microfluidic chips, and in particular relates to a microfluidic chip, a manufacturing method thereof, and an in-situ catalysis and detection method. The chip can be used for in-situ catalysis and detection of p-nitrophenol. Background technique [0002] Microfluidics (Microfluidics) refers to the science and technology involved in the use of micropipes (tens to hundreds of microns in size) to process or manipulate tiny fluids (nanoliters to Attoliters in volume). Emerging interdisciplinary disciplines of chemistry, fluid physics, microelectronics, new materials, biology, and biomedical engineering. Its goal is to integrate the functions of the entire laboratory, including sampling, dilution, reagent addition, reaction, separation, detection, etc., on the microchip, and it can be used multiple times. The main materials for making microfluidic chips are silicon wafers, glass, polydimethylsiloxane (PDMS),...

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Problems solved by technology

However, due to the high surface energy of metal nanoparticles, it is easy to aggregate and affect the catalytic effect, so it needs to be loaded on a solid substrate such as carbon, silica (Applied Surface Science, 258, 2012, 2717-2723), zeolite (Wiley-VCH , Weiheim, Germany, 1997), etc.

Heavy metal particles loaded on a solid matrix need to be added to the reaction solution for catalytic reduction. The separation process between the product and the catalyst is cumbersome and the reaction process cannot be detected in situ. In addition, the reaction system can only react once, and the reactant needs to be separated from the catalyst, resulting in The number of substances that undergo a reaction is limited

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