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Desensitizer for treating dentin hypersensitivity and preparation method thereof

A desensitizer and allergy technology, applied in the field of dental biomedical materials, can solve the problems of no biological activity and antibacterial and bacteriostatic effect, harm to human health of teeth, and affect the aesthetics of teeth, etc., and achieve good biocompatibility and biological activity. , easy to promote, does not affect the effect of dental aesthetics

Inactive Publication Date: 2017-08-18
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, common desensitizing materials have limitations: fluoride is slow to take effect because of the long time it takes for teeth to form secondary dentin, and tin fluoride can also discolor teeth and affect the appearance of teeth; The components contain glutaraldehyde, which is corrosive and teratogenic, and will cause harm to teeth and human health; calcium phosphate materials have no biological activity and antibacterial and antibacterial effects; bioactive composite materials have organic and inorganic interface bonding problems

Method used

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  • Desensitizer for treating dentin hypersensitivity and preparation method thereof
  • Desensitizer for treating dentin hypersensitivity and preparation method thereof
  • Desensitizer for treating dentin hypersensitivity and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] A kind of preparation that is used for bioactive glass-sodium alginate-phosphate desensitization agent, the steps are as follows:

[0041] (1) Preparation of micro-nano bioactive glass spheres of Si-Ca-P ternary system: Dissolve 2g of dodecylamine in 100mL of ethanol-deionized water mixed solution (volume ratio of ethanol to deionized water is 4:1 ), then add ethyl orthosilicate (16.00mL, 72mol), triethyl phosphate (1.64mL, 9.6mmol) and calcium nitrate tetrahydrate (10.04g, 43.2mmol) in sequence, the feeding interval is 30min, stir well , the white emulsion was obtained, and the temperature of the whole process was controlled at 30°C; the obtained white emulsion was centrifuged, and the precipitate was dried at 60°C for 24 h, and then heated at 600°C for 180 min to obtain the Si-Ca-P ternary system Nano bioactive glass spheres;

[0042] The SEM pictures of the obtained Si-Ca-P ternary system micro-nano bioactive glass spheres are as follows: figure 1 As shown, it is a...

Embodiment 2

[0047] A kind of preparation that is used for bioactive glass-sodium alginate-phosphate desensitization agent, the steps are as follows:

[0048] (1) Preparation of micro-nano bioactive glass spheres of Si-Ca-P ternary system: Dissolve 4g of dodecylamine in 100mL of ethanol-deionized water mixed solution (volume ratio of ethanol to deionized water is 3:1 ), then add ethyl orthosilicate (16.00mL, 72mmol), triethyl phosphate (1.40mL, 8.2mmol) and calcium nitrate tetrahydrate (6.21g, 26.7mmol) in sequence, the feeding interval is 30min, stir well , the white emulsion was obtained, and the temperature of the whole process was controlled at 40°C; the obtained white emulsion was centrifuged, the precipitate was dried at 70°C for 36 h, and then heated at 650°C for 240 min to obtain the Si-Ca-P ternary system Nano bioactive glass spheres;

[0049] For the SEM image of the obtained Si-Ca-P ternary system micro-nano bioactive glass spheres, see figure 1 , the particle size is 700nm; ...

Embodiment 3

[0053] A kind of preparation that is used for bioactive glass-sodium alginate-phosphate desensitization agent, the steps are as follows:

[0054] (1) Preparation of micro-nano bioactive glass spheres of Si-Ca-P ternary system: Dissolve 6g of dodecylamine in 120mL of ethanol-deionized water mixed solution (volume ratio of ethanol to deionized water is 5:1 ), then add ethyl orthosilicate (16.00mL, 72mmol), triethyl phosphate (1.22mL, 3.6mmol) and calcium nitrate tetrahydrate (3.39g, 14.4mmol) in sequence, the feeding interval is 30min, stir well , the white emulsion was obtained, and the temperature of the whole process was controlled at 50°C; the obtained white emulsion was centrifuged, the precipitate was dried at 80°C for 48 h, and then heated at 700°C for 300 min to obtain the Si-Ca-P ternary system Nano bioactive glass spheres;

[0055] For the SEM image of the obtained Si-Ca-P ternary system micro-nano bioactive glass spheres, see figure 1 , the particle size is 1100nm; ...

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Abstract

The invention discloses a desensitizer for treating dentin hypersensitivity and a preparation method thereof. The desensitizer is prepared from two parts: solid powder and dispersion liquid. Before use, the solid powder and the dispersion liquid are separately packaged, when in use, the solid powder and the dispersion liquid are mixed, and after the solid powder and the dispersion liquid are mixed uniformly, paste is formed and coated on an exposed dentin surface; the solid powder is made of micro-nano bioactive glass beads of a Si-Ca-P ternary system; the dispersion is sodium alginate-phosphate buffer solution. The preparation process of the desensitizer comprises preparation of the micro-nano bioactive glass beads of the Si-Ca-P ternary system and preparation of the sodium alginate-phosphate buffer solution. The desensitizer disclosed by the invention can effectively block and seal up a dentin tubule, induces to form a reparative dentin layer, is high in response speed, does not influence tooth attraction, and can be used as a desensitization material for dentin hypersensitivity; meanwhile, the preparation method disclosed by the invention is simple in process, does not require complex equipment, and is mild in preparation condition and easy to popularize.

Description

technical field [0001] The invention belongs to the technical field of dental biomedical materials, and in particular relates to a desensitizer for treating dentin hypersensitivity and a preparation method thereof. Background technique [0002] Caries, abrasion, etc. easily expose the dentin, resulting in dentin hypersensitivity. According to the theory of fluid dynamics, the effective method of treating dentin hypersensitivity is to seal the dentin tubules and form a restorative dentin layer. Therefore, an ideal desensitizing material should have good biocompatibility (without causing inflammatory reactions), be able to effectively block and seal dentin tubules, induce the formation of restorative dentin, and at the same time be simple to operate, have a fast onset of action, and have a long-lasting effect. Does not affect the appearance of teeth. At present, common desensitization materials include fluoride, resin desensitizers, calcium phosphate materials, and bioactive...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K6/027A61K6/033A61K6/097A61K6/838A61K6/898
CPCA61K6/836A61K6/838A61K6/898
Inventor 陈晓峰唐洁吟赵夫健王聿栋刘聪
Owner SOUTH CHINA UNIV OF TECH
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