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Multifunctional polymer nanoparticle, as well as preparation method and application thereof

A polymer nanoparticle and nanoparticle technology, applied in the field of medicine, can solve the problem of iron oxide glioma, and achieve the effects of reducing toxicity, good biocompatibility, and improving solubility

Active Publication Date: 2017-08-18
EAST CHINA NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, superparamagnetic iron oxide contrast agents have entered the early stage of clinical research. Typical studies include Lumiren for intestinal contrast, Feridex IV for liver and spleen contrast, but the clinical research of iron oxide for glioma is still in progress. No

Method used

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  • Multifunctional polymer nanoparticle, as well as preparation method and application thereof
  • Multifunctional polymer nanoparticle, as well as preparation method and application thereof
  • Multifunctional polymer nanoparticle, as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Preparation of pGG-PTX / SPION nanoparticles

[0045] Dissolve 25mg of pGG-PTX in 10ml of 0.5% sodium cholate solution, and stir evenly with a glass rod to obtain a polymer-coupled PTX aqueous solution; dissolve superparamagnetic iron oxide in a mixture of 20ml of dichloromethane and acetone to obtain a contrast Add organic phase solution; add oil phase solution drop by drop to water phase solution, and keep stirring with glass rod; ultrasonic 1.5min, power 65% interval ultrasonic time 1s, milky small droplets gradually disappear, and gradually turn from brown to light yellow solution ;Stir in a round bottom flask at room temperature for 20-30min, 400rpm; after stirring, pour it into a rotary evaporating flask, set the temperature at 35°C, and evaporate for 20min-30min until it no longer boils; finally take out the solution and put it in a freeze dryer, After 7 days, milky white flocculent solid pGG-PTX / SPION nanoparticles were obtained.

Embodiment 2

[0047] The freeze-dried pGG-PTX / SPION nanoparticles were dissolved in distilled water, and an appropriate amount of strong acid was added to degrade the polymer. The content of SPION in pGG-PTX / SPION was quantitatively measured to be 6.34wt% by ICP.

Embodiment 3

[0049] pGG-PTX / SPION nanoparticles were configured into a 1.5mg / ml solution, and the particle size was measured with a dynamic light scattering instrument after ultrasonication for 10 minutes. The results are as follows figure 2 As shown, the particle size dispersion is good, and the average particle size is 113.03±0.6nm.

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Abstract

The invention discloses a multifunctional polymer nanoparticle, as well as a preparation method and application thereof. The nanoparticle is formed by a center core and a capsule shell coating the core, wherein the center core is superparamagnetic ferroferric oxide SPION contrast agent, and the outer capsule shell is polyglutamic acid modified polymer-drug conjugate pGG-PTX of polymer conjugated taxol containing two carboxyl groups; and an emulsion-solvent evaporation method is adopted for preparing the nanoparticle. The nanoparticle is applied to preparation of medicines for treating and diagnosing glioma, and has an image function to feed back development of a medicine in real time, so that the time for diagnosis and treatment can be shortened for clinical doctors in the future, and a powerful support is provided to accurate judgment of illness conditions and reasonable individual administration.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a multifunctional polymer nanoparticle and its preparation method and application. Background technique [0002] Many studies have shown that tumor heterogeneity is one of the important characteristics of malignant tumors. There can be many different gene subtypes or cell subtypes in the same tumor. The same tumor may appear differently in different individuals, or even the same Tumor cells in individuals also have different characteristics and differences. Because of this, tumors respond differently to drugs during treatment. At present, most of them are still "one-size-fits-all" in clinical practice, resulting in differences in treatment effects. very big. [0003] Therefore, in order to solve the above problems, as early as 2004, the US FDA strongly recommended that the scientific community adopt individualized treatment. However, in the current implementation of individualized treat...

Claims

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Application Information

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IPC IPC(8): A61K47/64A61K47/69A61K47/02A61K31/337A61K49/08A61K49/14A61K49/18A61P35/00B82Y30/00B82Y40/00B82Y5/00
CPCA61K47/02A61K49/085A61K49/146A61K49/1872A61K31/337B82Y5/00B82Y30/00B82Y40/00
Inventor 王依婷汉琳范明雪张金芳刘秧闫志强王镜朱建中俞磊
Owner EAST CHINA NORMAL UNIVERSITY
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