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A nine-membered ring lactone derivative derived from marine fungi and its preparation method and application

A marine fungus, nine-membered ring technology, applied in the field of nine-membered ring lactone derivatives and its preparation, can solve side effects and other problems, achieve significant α-glucosidase inhibitory activity, and broad market application prospects

Active Publication Date: 2019-12-03
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these drugs have more obvious gastrointestinal side effects, such as abdominal pain, bloating, diarrhea

Method used

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  • A nine-membered ring lactone derivative derived from marine fungi and its preparation method and application
  • A nine-membered ring lactone derivative derived from marine fungi and its preparation method and application
  • A nine-membered ring lactone derivative derived from marine fungi and its preparation method and application

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Experimental program
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Effect test

Embodiment 1 9

[0024] The preparation of embodiment 1 nine membered ring lactone derivatives

[0025] 1. The nine-membered cyclic lactone derivative of the present invention is isolated from the fermentation broth of the marine fungus Ascomycota sp.SK2YWS-L.

[0026] The marine fungus Ascomycota sp.SK2YWS-L was isolated from the fruit of the mangrove plant Kandelia obovata in Shankou, Guangxi, China, and was preserved in the China Center for Type Culture Collection on April 21, 2016, with the preservation number CCTCC M 2016217. Address: Wuhan University, Wuhan (see patent 201610509145.3).

[0027] Specifically, the preparation method of the nine-membered ring lactone derivative is as follows:

[0028] (1) Seed culture of the fungus Ascomycota sp.SK2YWS-L: the culture medium was made into a test tube slope, the strains were picked and inserted into the slope, and cultured at 28°C for 3 days;

[0029] The composition of the medium is by weight: 0.3% of glucose, 0.1% of yeast extract, 0.5% o...

Embodiment 2 9

[0038] In vitro α-glucosidase inhibition experiment of embodiment 2 nine-membered cyclic lactone derivatives

[0039] 1. Test material

[0040] p-nitrophenol-α-glucoside (pNPG), purchased from aladdin reagent company; dipotassium hydrogen phosphate and potassium dihydrogen phosphate, purchased from aladdin reagent company; α-glucosidase, purchased from aladdin reagent company; Sugar, purchased from Aladdin Reagent Company; analytically pure DMSO, purchased from Guangzhou Chemical Reagent Factory; iMark microplate reader.

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Abstract

The invention discloses a nine-membered ring lactone derivative derived from marine fungi as well as a preparation method and application thereof. The structure formula of the nine-membered ring lactone derivative is shown as a formula (I) which is shown in the description. The compound is separated from the marine fungi Ascomycota sp. SK2YWS-L, has obvious alpha-glucosaccharase inhibition activity, has a broad market prospect in preparation of hypoglycemic drugs, especially preparation of drugs for treating type II diabetes.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical compounds, and in particular relates to a nine-membered ring lactone derivative derived from a marine fungus and a preparation method and application thereof. Background technique [0002] Diabetes is a group of metabolic diseases characterized by hyperglycemia. Hyperglycemia is caused by defective insulin secretion or impaired biological action, or both. The long-term high blood sugar in diabetes leads to chronic damage and dysfunction of various tissues, especially the eyes, kidneys, heart, blood vessels, and nerves. With the improvement of living standards, unhealthy lifestyles and eating habits are gradually affecting people's quality of life. One of the serious consequences is the increasing number of diabetic patients. It is estimated that by 2030, there will be 439 million diabetic patients worldwide. [0003] At present, there is no cure for diabetes, but diabetes is controlled th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D407/04C12P17/16A61P3/10C12R1/645
CPCC07D407/04C12P17/162
Inventor 佘志刚刘昭明谭春兵陈森华黄锡山
Owner SUN YAT SEN UNIV
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