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Capsule containing indomethacin solid dispersion

A technology of indomethacin solid and indomethacin, which is applied in the directions of medical preparations containing active ingredients, medical preparations without active ingredients, capsule delivery, etc., can solve the problems of low dissolution rate of indomethacin capsules and the like , to achieve the effect of improving bioavailability, solubility and dissolution rate

Inactive Publication Date: 2017-08-22
HUAYI PHARMA ANHUI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The invention provides a capsule containing indomethacin solid dispersion, which solves the problem of low dissolution rate of existing indomethacin capsules

Method used

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  • Capsule containing indomethacin solid dispersion
  • Capsule containing indomethacin solid dispersion
  • Capsule containing indomethacin solid dispersion

Examples

Experimental program
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Effect test

Embodiment 1

[0029] This embodiment provides a capsule containing a solid dispersion of indomethacin, which consists of a solid dispersion of indomethacin, a pharmaceutically acceptable diluent and a lubricant;

[0030] The capsule containing indomethacin solid dispersion is made by following preparation method:

[0031] The indomethacin solid dispersion is prepared by the following preparation method: take 125g of water-soluble carrier material and add it to 750ml of solvent, stir to dissolve, then add 50g of indomethacin, stir to dissolve, stir at low speed for 1h and then rotate The organic solvent is removed by evaporation, and the residue is dried under reduced pressure in an oven at 45-55°C for 18 hours. After drying, it is ground in a mortar and passed through an 80-mesh sieve to obtain a solid dispersion containing indomethacin.

[0032] Then add 15g of microcrystalline cellulose and 0.5g of magnesium stearate, mix evenly, and fill in capsules to obtain capsules containing indometh...

Embodiment 2

[0038] This embodiment provides a capsule containing a solid dispersion of indomethacin, which consists of a solid dispersion of indomethacin, a pharmaceutically acceptable diluent and a lubricant;

[0039] The capsule containing the indomethacin solid dispersion is made by the following preparation method: the indomethacin solid dispersion is made by the following preparation method: take 150g of water-soluble carrier material and add it to 750ml of solvent, stir to dissolve, then add 50g of indomethacin, stir to dissolve, stir at low speed for 1h, then remove the organic solvent by rotary evaporation, dry the residue in an oven at 45-55°C for 12h under reduced pressure, grind it in a mortar after drying, pass 80 mesh sieve to obtain a solid dispersion containing indomethacin.

[0040] Then add 10 g of microcrystalline cellulose and 1.0 g of magnesium stearate, mix well, and fill in capsules to obtain capsules containing indomethacin solid dispersion with a specification of 5...

Embodiment 3

[0046] This embodiment provides a capsule containing a solid dispersion of indomethacin, which consists of a solid dispersion of indomethacin, a pharmaceutically acceptable diluent and a lubricant;

[0047] The capsule containing indomethacin solid dispersion is made by following preparation method:

[0048] The indomethacin solid dispersion is prepared by the following preparation method: take 100g of water-soluble carrier material and add it to 700ml of solvent, stir to dissolve, then add 50g of indomethacin, stir to dissolve, stir at low speed for 1h and then rotate The organic solvent is removed by evaporation, and the residue is dried under reduced pressure in an oven at 45-55°C for 24 hours, ground in a mortar after drying, and passed through an 80-mesh sieve to obtain a solid dispersion containing indomethacin.

[0049] Then add 20g of microcrystalline cellulose and 0.25g of magnesium stearate, mix evenly, and fill in capsules to obtain capsules containing indomethacin ...

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Abstract

The invention discloses a capsule containing indomethacin solid dispersion, belonging to the technical field of medicinal preparations. The capsule is composed of the indomethacin solid dispersion, a pharmaceutically acceptable diluent and a pharmaceutically acceptable lubricant. The indomethacin solid dispersion is prepared through the following steps: adding a water-soluble carrier material into a solvent and dissolving the water-soluble carrier material under stirring; then adding indomethacin and dissolving indomethacin under stirring; carrying out low-speed stirring for 1 h and then carrying out rotary evaporation so as to completely remove the organic solvent; subjecting a residue to pressure-reduced drying in a baking oven for 12 to 24 h; and grinding the dried residue in a mortar and carrying out sieving with a 80-mesh sieve so as to obtain the indomethacin solid dispersion. The capsule containing the indomethacin solid dispersion in the invention is improved in solubility and dissolution rate, so the bioavailability of indomethacin is effectively improved.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a capsule containing indomethacin solid dispersion. Background technique [0002] The chemical name of indomethacin is: 2-methyl-1-(4-chlorobenzoyl)-5-methoxy-1H-indole-3-acetic acid, and the molecular formula is C 19 h 16 ClNO 4 , the molecular weight is 357.79, and the structural formula is as follows: [0003] [0004] Indomethacin is a white or slightly yellow crystalline powder with a melting point of 158-162°C. It is soluble in acetone, slightly soluble in ethanol, chloroform and ether, almost insoluble in water, tasteless and almost odorless. [0005] Indomethacin has anti-inflammatory, antipyretic and analgesic effects, and its mechanism of action is to reduce the synthesis of prostaglandins by inhibiting cyclooxygenase, inhibit the formation of pain nerve impulses in inflammatory tissues, and inhibit inflammatory reactions, including inhibition ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/405A61K47/32A61K47/10A61K47/34A61K47/38A61P29/00A61K9/14
CPCA61K9/146A61K9/4808A61K9/4866A61K31/405
Inventor 高煜操铖
Owner HUAYI PHARMA ANHUI CO LTD