Medical application of butyric acid compounds and derivatives thereof
A technology of compounds and derivatives, applied in the field of medicine, can solve problems such as poor effect of diabetic complications
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Embodiment 1
[0040] Embodiment 1: Preparation of the compound of formula (1) and its application in the treatment of diabetic complications in mammals
[0041] Use the dried and mature fruit of burdock (Arctium Lappa L.) as raw material, crush it into a coarse powder, add 6 to 10 times the amount of 50% to 95% ethanol, and reflux extraction for 2 to 3 times, each time for 1 to 6 hours, Filter, combine the filtrates, and concentrate under reduced pressure until the concentrated extract has no alcohol smell. The obtained liquid extract was allowed to stand at room temperature, the upper liquid part was poured off, the lower dry extract was suspended in water, and extracted with ethyl acetate until the extract was colorless. Concentrate the extract under reduced pressure into a dry extract, and dry it in vacuum at 60° C. to obtain the total lignans of Arctium Fructus with a yield of 5% to 20%.
[0042] Then through column chromatography separation, recrystallization, etc. separation or purif...
Embodiment 2
[0046] Embodiment 2: When the compound of formula (1) contains a hydroxyl group, derivatives derived from the hydroxyl group and their preparation methods and their use in the preparation of anti-diabetic complications drugs
[0047] When the compound of formula (1) contains a hydroxyl group, it can react with a halogenated hydrocarbon or an acyl halide to introduce a substituent group at the para-position of the phenyl group to generate derivatives such as ethers, esters or alkanoyloxys; Hydroxymethyl, introducing substituted benzyl or methylamine, isopropyl, cyclopentyl, benzylamino and other common groups to generate derivatives; the carboxyl group of butyric acid can also be combined with alkalis, halogenated hydrocarbons, alcohols, and chlorinating agents , acid chloride, ammonia or organic amines to derive various organic acid salts, alcohol esters, acid halides, acid anhydrides and amides and other carboxylic acid derivatives.
Embodiment 3
[0049] Embodiment 3: the preparation and application of the mixture that formula (1) compound forms
[0050] The mixture provided by the present invention is characterized in that the mixture contains one or more than one compound of formula (1), wherein the sum of the contents of said compounds is greater than or equal to 10% of the total amount.
[0051] The mixture can be prepared through artificial synthesis, and can also be obtained through the lactone ring-opening treatment and separation and purification of lignan lactone compounds contained in the Compositae plant burdock.
[0052] From plants it is prepared as follows:
[0053] Use the dried and mature fruit of burdock (Arctium Lappa L.) as raw material, crush it into a coarse powder, add 6 to 10 times the amount of 50% to 95% ethanol, and reflux extraction for 2 to 3 times, each time for 1 to 6 hours, Filter, combine the filtrates, and concentrate under reduced pressure until the concentrated extract has no alcohol ...
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