Quaternary ammonium salt modified chitosan microspheres and preparation method and application thereof

A technology of chitosan microspheres and quaternary ammonium salts, applied in the direction of botany equipment and methods, applications, chemical instruments and methods, etc., can solve the problems of high transportation and storage costs, inability to be effectively recovered, and poor bacterial scale action ability , to achieve the effect of broad application prospects, abundant reserves, and non-pollution

Active Publication Date: 2017-08-29
ZHEJIANG GONGSHANG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, oxidizing sterilants also have disadvantages: when the content of organic matter in water is high, chlorine gas sterilization will produce chlorinated organic substances, which are not stable and can cause cancer; the cost of transportation and storage is high; poor ability
However, the fungicide in this state will remain in the water body, and cannot be effectively recovered, let alone recycled, and there is a problem of waste of resources

Method used

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  • Quaternary ammonium salt modified chitosan microspheres and preparation method and application thereof
  • Quaternary ammonium salt modified chitosan microspheres and preparation method and application thereof
  • Quaternary ammonium salt modified chitosan microspheres and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0064] (1) 1.0g chitosan (CTS) is placed in 50ml mass fraction and is 4% acetic acid solution, stirs to dissolving, stirs 15min with 250r / min rotation rate, adds the liquid paraffin of 200mL, is heated up to after stirring 10min again At 50°C, add 4 drops of emulsifier Span80 dropwise, and emulsify for 10 minutes.

[0065] (2) Add 2 mL of formaldehyde in step (1), react at 50°C for 1.5h, then raise the temperature to 70°C, add 10% NaOH aqueous solution dropwise, and adjust the pH of the solution to 9. Afterwards, 4 mL of epichlorohydrin was slowly added dropwise, and after reacting for 5 hours, it was washed with distilled water, then petroleum ether and absolute ethanol in sequence, and then washed with water repeatedly until the pH value reached neutral. Dry to constant weight in a vacuum desiccator at 50°C.

[0066] (3) The cross-linked chitosan microspheres prepared in step (2) were heated to 60° C. for 9 h with 30 mL of 1 mol / L hydrochloric acid aqueous solution. Then w...

Embodiment 2

[0103] (1) 1.0g chitosan (CTS) is placed in 50ml mass fraction and is 4% acetic acid solution, stirs to dissolving, stirs 15min with 250r / min rotation rate, adds the liquid paraffin of 200mL, is heated up to after stirring 10min again At 50°C, add 4 drops of emulsifier Span80 dropwise, and emulsify for 10 minutes.

[0104] (2) Add 2.0 mL of formaldehyde in step (1), react at 50°C for 1.5h, then raise the temperature to 60°C, add 10% NaOH aqueous solution dropwise, and adjust the pH of the solution to 9. Afterwards, 4 mL of epichlorohydrin was slowly added dropwise, and after reacting for 5 hours, it was washed with distilled water, then petroleum ether and absolute ethanol in sequence, and then washed with water repeatedly until the pH value reached neutral. Dry to constant weight in a vacuum desiccator at 50°C.

[0105] (3) Heat the cross-linked chitosan microspheres prepared in step (2) to 70° C. for 9 h with 40 mL of 1 mol / L hydrochloric acid aqueous solution. Then wash w...

Embodiment 3

[0109] (1) 1.0g chitosan (CTS) is placed in the acetic acid solution that 50ml mass fraction is 4%, stirs to dissolving, stirs 15min with 250r / min rotating speed, adds the liquid paraffin of 150mL, is heated up to after stirring 10min again At 50°C, add 4 drops of emulsifier Span80 dropwise, and emulsify for 10 minutes.

[0110] (2) Add 3.0mL formaldehyde in step (1), react at 60°C for 2h, then raise the temperature to 70°C, add 10% NaOH aqueous solution dropwise, and adjust the pH of the solution to 9. Afterwards, 4 mL of epichlorohydrin was slowly added dropwise, and after reacting for 5 hours, it was washed with distilled water, then petroleum ether and absolute ethanol in sequence, and then washed with water repeatedly until the pH value reached neutral. Dry to constant weight in a vacuum desiccator at 50°C.

[0111] (3) Heat the cross-linked chitosan microspheres prepared in step (2) to 70° C. for 9 h with 40 mL of 1 mol / L hydrochloric acid aqueous solution. Then wash w...

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Abstract

The invention discloses quaternary ammonium salt modified chitosan microspheres and a preparation method thereof. The preparation method comprises the following steps: with cross-linked chitosan microspheres as a parent, performing sufficient swelling; adding a ligand choline chloride to regulate the pH value of the system; performing a modifying reaction; after the reaction is finished, performing washing and drying to obtain the quaternary ammonium salt modified chitosan microspheres. The invention also provides application of the quaternary ammonium salt modified chitosan microspheres as a sterilizing agent in drinking water. The quaternary ammonium salt modified chitosan microspheres disclosed by the invention can serve as a novel modified sterilizing agent; the sterilizing effect is enhanced by introducing the quaternary ammonium salt with a good sterilizing effect and carrying positive charges.

Description

technical field [0001] The invention belongs to the field of fungicides, and in particular relates to a quaternary ammonium salt modified chitosan microsphere and a preparation method and application thereof. Background technique [0002] China's water shortage has sounded the alarm, and more importantly, the current situation of water security is not optimistic. In recent years, there have been endless news about drinking unqualified water threatening human health. This is mainly due to the fact that people used to drink boiled cold water, but now they drink bottled water. Bottled water has to go through multiple processes and transportation from production to sale before reaching consumers. Although this process will go through strict checks, it is inevitable that mistakes will occur in some links and cause pollution. Bottled water pollution is mostly poisoning or infection caused by bacteria or other microorganisms. [0003] At present, common sterilizing agents inclu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/16A01N59/20A01N59/16A01P1/00C02F1/50C08B37/08
CPCA01N43/16A01N59/16A01N59/20C02F1/50C02F2303/04C08B37/003A01N2300/00
Inventor 王彦波勇括赵新珍阎亚利熊春华
Owner ZHEJIANG GONGSHANG UNIVERSITY
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