Method for preparing levofloxacin hydrochloride

A technology of levofloxacin hydrochloride and cyclic acid, which is applied in the field of organic compound synthesis, can solve the problems of increased post-processing workload and three wastes, poor environmental protection and economic efficiency, and no specific introduction, so as to reduce environmental pollution and consumption of industrial raw materials, and reduce production costs , The effect of simplifying the process
CN107141306AInactive Publication Date: 2017-09-08TAICANG DATANG CHEM FIBER FACTORY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TAICANG DATANG CHEM FIBER FACTORY
Publication Date
2017-09-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a method for preparing levofloxacin hydrochloride. The method comprises preparation of 3-(2-hydroxyl-1-methyl-ethylamino)-2-(2,3,4,5-tetrafluorobenzoyl)-ethyl acrylate, preparation of levo-oxygen main naphthenic acid, and preparation of the levofloxacin hydrochloride. The method is simple, low in production cost, high in product yield, good in product quality, economical, environmentally friendly, and low in three-waste emission load, and realizes effective separation and recycling of most byproducts, is convenient for industrial production and has great significance of promotion.
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Description

technical field

[0001] The invention belongs to the technical field of organic compound synthesis, and in particular relates to a method for preparing levofloxacin hydrochloride. Background technique

[0002] Fluoroquinolones have achieved great success in clinical anti-infective treatment due to their high efficiency, broad antibacterial spectrum and low toxicity. The chemical name of levofloxacin hydrochloride is (s)-(-)-9-fluoro-2,3-dihydro-3-methyl-10-[4-methyl-1-piperazinyl]-7-oxo- 7-hydropyrido[1,2,3-de][1,4]benzoxazine-6-carboxylate hydrochloride.

[0003] At present, the domestic industrialized production of levofloxacin is mainly based on (2,3,4,5)-tetrafluorobenzoic acid as raw material, after acid chlorination, coupling with N,N-dimethylaminoethyl acrylate, and replacement with L-aminopropanol. , Cyclization, hydrolysis and condensation with N-methylpiperazine refined. In 2005, "Journal of Chemical Engineering of Universities" No. 5, Volume 19, disclosed a new ...

Claims

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