Polysulfone dialysis membrane, and production method and application thereof

Abstract

The invention provides a polysulfone dialysis membrane, and a production method and an application thereof. A polysulfone-polyethylene glycol block copolymer in the production method is used as a pore forming agent. The production method comprises the following steps: dissolving 10-25 parts by weight of polysulfone and 1-25 parts by weight of the polysulfone-polyethylene glycol block copolymer in 60-100 parts by weight of an organic solvent, and mixing above materials and the organic solvent to prepare a membrane casting solution; and cooling and defoaming the membrane casting solution, pouring the obtained solution onto a substrate, scraping a membrane, volatilizing the organic solvent in the membrane casting solution, placing the volatilized solution, solidifying the solution to form a membrane, and immersing the formed membrane in water to completely displace the organic solvent in the membrane in order to obtain the polysulfone dialysis membrane. The polysulfone-polyethylene glycol block copolymer used as the pore forming agent promotes the formation of membrane pores, so the pore forming agent is firmly anchored to the surface of the polysulfone base membrane, the loss problem of a hydrophilic pore forming agent is solved, and the membrane is endowed with a permanent hydrophilic property; and the polysulfone dialysis membrane also has the advantages of high membrane flux, high flux recovery rate and good stability.

Description

technical field [0001] The invention belongs to the field of polymer separation membrane preparation, and relates to a polysulfone dialysis membrane, a preparation method and application thereof. Background technique [0002] Polysulfone dialysis membrane is currently the most widely used clinical hemodialysis membrane due to its advantages of good thermal stability, high mechanical strength, and strong chemical inertness. Polysulfone dialysis membranes are usually prepared by a non-solvent-induced phase inversion method. Due to the poor porosity of polysulfone materials, the addition of porogens is essential in the membrane-making process. The main function of the porogen is to increase or inhibit the formation of macropores, promote the increase of membrane porosity and the permeability of membrane pores. At present, the commonly used porogens are mostly some water-soluble inorganic salts (such as lithium chloride and lithium nitrate) and hydrophilic polymers (such as po...

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Problems solved by technology

[0004] CN101259387A discloses a controllable flux anti-protein pollution polyethersulfone ultrafiltration membrane and its preparation method, and its polyoxyethylene / polyoxypropylene / polyoxyethylene amphiphilic block copolymer (Pluronic F127) is prepared as a porogen The controllable flux anti-protein fouling polyethersulfone ultrafiltration membrane preliminarily proved the pore-forming ability of the amphiphilic block copolymer, but because the hydrophobic segment of the block copolymer is polyoxypropylene, its physical and chemical properties are different from those of the hydrophobic Polyethersulfone substrates are quite different, and there is a problem of poor compatibility

CN102432782A discloses an amphiphilic tri-block copolymer and its preparation method and a polyethersulfone hollow fiber membrane modified by blending thereof. The amphiphilic tri-block copolymer is composed of polyvinylpyrrolidone, polyacrylic acid and Composed of polystyrene or polyacrylonitrile segments, the hollow fiber membrane prepared by blending the amphiphilic triblock copolymer with polyethersulfone can solve the problem of loss of the water-soluble porogen polyvinylpyrrolidone, but the two The structure of the hydrophilic tri-block copolymer is complicated and the preparation method is complicated