Method for preparing mesoporous silicon nanoparticle coating loaded with heparin and Cu<2+> on surface of biological material

A technology of nanoparticles and biomaterials, applied in coatings, drug delivery, pharmaceutical formulations, etc., can solve the problem that the fixed amount of heparin on the surface is difficult to ensure the long-term sustained effect of implanted materials in blood vessels, and it is difficult to ensure the sustained and controlled release of heparin. Its activity and other issues can achieve good blood compatibility, improve the success rate of implantation, and improve the effect of biocompatibility
CN107158481AActive Publication Date: 2017-09-15HUAIYIN INSTITUTE OF TECHNOLOGY
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
HUAIYIN INSTITUTE OF TECHNOLOGY
Publication Date
2017-09-15

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Abstract

The invention discloses a method for preparing a mesoporous silicon nanoparticle coating loaded with heparin and Cu<2+> on the surface of a biological material. The method comprises the steps of carrying out surface modification on mesoporous silicon nanoparticles to obtain amino-modified mesoporous silicon nanoparticles to load heparin and Cu<2+> into a mesoporous duct; modifying the surfaces of the nanoparticles by using albumin; and finally fixing the nanoparticles on the surface of the dopamine-modified biological material to obtain the mesoporous silicon nanoparticle coating loaded with the heparin and the Cu<2+>. Surface modification is carried out on a material or device implanted into a blood vessel by adopting the method, so that the loading capacity and the release behavior of the heparin and the Cu<2+> on the surface of the material can be effectively controlled, the material is endowed with good blood compatibility and regeneration of blood vessel endothelium can be significantly promoted, thereby effectively improving the biocompatibility and the implant success rate of the material.
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Description

technical field

[0001] The invention relates to the technical field of biological materials, in particular to a method for preparing heparin and Cu on the surface of biological materials. 2+ A method for the coating of mesoporous silicon nanoparticles. Background technique

[0002] The anticoagulant performance and endothelial repair performance of the surface of intravascular implant materials or devices (such as vascular stents, artificial blood vessels, etc.) are still the main problems in their clinical application, and the response to the surrounding environment of implantation can be adjusted by changing the surface properties of materials. Improving the performance and function of implanted materials is of great significance to the clinical application of intravascular implanted materials or devices. So far, many surface modification technologies have been used to improve the anticoagulant properties of materials and induce endothelial regeneration in situ, but the e...

Claims

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