Preparation method, product and application of phthalate molecularly imprinted polymer

A technology of phthalic acid and phthalic acid di, which is applied in the direction of alkali metal compounds, chemical instruments and methods, alkali metal oxides/hydroxides, etc., and can solve problems such as irregular imprinted polymer particles and template leakage , achieve the effect of shortening the detection time, regular shape and good monodispersity

Active Publication Date: 2019-03-22
YANGTZE NORMAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] Another object of the present invention is to use magnetic nanoparticles as a carrier to prepare phthalate-based magnetic molecularly imprinted polymers by using virtual templates and surface imprinting technology, so as to solve the irregularity of imprinted polymer particles and template leakage prepared by existing methods. And only one target can be adsorbed; at the same time, the separation time is shortened, the efficiency of solid phase extraction is improved, and the analysis of multiple residues of phthalates in complex samples is satisfied.

Method used

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  • Preparation method, product and application of phthalate molecularly imprinted polymer
  • Preparation method, product and application of phthalate molecularly imprinted polymer
  • Preparation method, product and application of phthalate molecularly imprinted polymer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1 (see figure 1 )

[0046] 1. Simulation of molecularly imprinted polymer pre-assembly system

[0047] 1. Using Gaussian software, geometrically optimize all template molecules and functional monomer molecules at the B97D3 / 6-31+g* level, and calculate the NBO charge distribution of the molecules to analyze the possible combination of templates and functional monomers site. The optimized structure and charge distribution of template molecules and functional monomers are as follows: figure 2 shown.

[0048] 2. Optimize the structure of the composite system composed of the interaction between the template and the functional monomer at the B97D3 / 6-31+g* level and calculate its energy, compare the strength of the interaction between the template and the functional monomer through the binding energy ΔE, and select the function Monomer; the calculation of binding energy ΔE is shown in formula (1):

[0049] ΔE=E complex –E template –nE monomer (1)

[0050]...

Embodiment 2

[0074] 1. The simulation of the molecularly imprinted polymer pre-assembly system is the same as that in Example 1;

[0075] 2. The preparation of magnetic nanoparticles (Fe3O4@SiO2-MPS) is the same as in Example 1;

[0076] 3. The preparation of the virtual template is the same as in Example 1;

[0077] 4. Preparation of Magnetic Molecularly Imprinted Polymers

[0078] Dissolve 0.2mmol of bis(10-methoxy-10-oxodecanyl)phthalate and 0.8mmol of MAA in 25mL of toluene to fully mix the template molecules and monomers, then let stand at room temperature for 4h to obtain the prepared polymer; adding magnetic nanoparticles (Fe 3 o 4 @SiO 2 - MPS) 0.15 mg, cross-linking agent EGDMA 4.0 mmol and initiator AIBN 17.2 mg, mix uniformly, pass nitrogen gas for 5 min, seal, polymerize at 65° C. for 24 h, and magnetically separate to obtain an imprinted polymer. The preparation method of non-magnetic molecularly imprinted polymer (M-NIP) is the same as that of M-MIP except that no templa...

Embodiment 3

[0083] 1. The simulation of the molecularly imprinted polymer pre-assembly system is the same as that in Example 1;

[0084] 2. Magnetic nanoparticles (Fe 3 o 4 @SiO 2 -MPS) is prepared with embodiment 1;

[0085] 3. The preparation of the virtual template is the same as in Example 1;

[0086] 4. Preparation of Magnetic Molecularly Imprinted Polymers

[0087] Dissolve 0.2mmol of bis(10-methoxy-10-oxodecanyl)phthalate and 0.8mmol of MAA in 30mL of toluene to fully mix the template molecules and monomers, then let stand at room temperature for 4h to obtain the prepared polymer; adding magnetic nanoparticles (Fe 3 o 4 @SiO 2- MPS) 0.2mg, cross-linking agent EGDMA 4.0mmol and initiator AIBN 21.5mg, mix well, pass nitrogen gas for 5min, seal, and polymerize at 65°C for 24h to obtain imprinted polymer. The non-magnetic molecularly imprinted polymer (M-NIP) was prepared according to the above method except that no template was added. The elution of the template molecule was ...

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Abstract

The invention discloses a preparation method as well as a product and application of a phthalate molecularly imprinted polymer. The preparation method comprises the following steps: step 1: simulating a phthalate molecularly imprinted polymer pre-assembly system through a computer; step 2: preparation of Fe3O4@SiO2 magnetic nanoparticles; step 3: preparation of virtual template phthalate (10-methoxyl-10-oxodecyl); and Step 4: preparation of a magnetic molecularly imprinted polymer. The obtained PAEs magnetic molecularly imprinted polymer is uniform in morphology and can be used to adsorb ten kinds of PAEs at the same time, and the target is separated and enriched in the case of external magnetic field at one time. The printing efficiency and the adsorption performance of MIPs are improved by computer simulation. The rapid separation and multi-residue detection of PAEs in complex samples is achieved, and the PAEs magnetic molecularly imprinted polymer has a good application prospect.

Description

technical field [0001] The invention belongs to the field of polymer materials, and in particular relates to a preparation method of a phthalate molecularly imprinted polymer and its product and application. Background technique [0002] Phthalates (PAEs) are commonly used plasticizers and are used in the production of medical products, plastic toys, beauty products and food packaging. Mass production and application make it widely distributed in the environment, and have toxic effects on the reproductive system and endocrine system. Due to the potential hazards of PAEs to human health, the International Cancer Research Center (IARC) has included two PAEs in the IARC carcinogen list. The food safety regulations of all countries in the world prohibit the use of PAEs as food additives in food production. In June 2011, the Ministry of Health issued an emergency announcement to list 17 PAEs substances as non-edible substances that may be added illegally in food and food additiv...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F222/14C08F220/06C08K9/06C08K3/36C08K3/22C08J9/28B01J20/26B01J20/28B01J20/30
CPCB01J20/268B01J20/28009C08F222/14C08J9/28C08J2335/02C08K3/22C08K3/36C08K9/06C08K2003/2275C08K2201/011C08F220/06
Inventor 卢春霞汪建华李昌满高晓旭周琴
Owner YANGTZE NORMAL UNIVERSITY
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