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Azithromycin dry suspension and preparation method thereof

A technology for azithromycin and dry suspension, which is applied in the field of azithromycin dry suspension and its preparation, which can solve the problems of affecting drug efficacy, children prone to nausea, and children's difficulty in taking medicine, so as to improve the drug's effective rate and granulate Better effect, excellent effect of alkalinity and sedimentation volume ratio and other indicators

Active Publication Date: 2017-09-29
HAINAN JINXING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing azithromycin dry suspension often has obvious bitterness, and nausea is easy to occur when children take it, which makes it difficult for children to take the medicine and affects the drug effect.

Method used

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  • Azithromycin dry suspension and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0022] A dry suspension of azithromycin, comprising the following raw materials: 100 parts of azithromycin, 55 parts of sodium citrate, 85 parts of sodium carboxymethylcellulose, 1700 parts of powdered sugar and 24 parts of sweet orange essence;

[0023] Among them, azithromycin is the main drug, sodium citrate is the flocculant, sodium carboxymethylcellulose is the suspending agent, powdered sugar is the suspending agent and flavoring agent, and sweet orange essence is the aromatic agent.

[0024] The preparation method of above-mentioned azithromycin dry suspension comprises the following steps:

[0025] (1) Crushing and sieving: Azithromycin, sodium citrate, sodium carboxymethylcellulose, and powdered sugar are respectively added into the hopper of the universal pulverizer to pulverize, and then pass through an 80-mesh sieve after pulverization;

[0026] (2) Granulation: add the sieved raw materials in step (1) into the high-efficiency wet granulator and mix them evenly, ad...

Embodiment 2

[0030] A dry suspension of azithromycin comprising the following raw materials: 100 parts of azithromycin, 65 parts of sodium citrate, 95 parts of sodium carboxymethylcellulose, 1750 parts of powdered sugar and 28 parts of sweet orange essence;

[0031] Among them, azithromycin is the main drug, sodium citrate is the flocculant, sodium carboxymethylcellulose is the suspending agent, powdered sugar is the suspending agent and flavoring agent, and sweet orange essence is the aromatic agent.

[0032] The preparation method of above-mentioned azithromycin dry suspension comprises the following steps:

[0033] (1) Crushing and sieving: Azithromycin, sodium citrate, sodium carboxymethylcellulose, and powdered sugar are respectively added into the hopper of the universal pulverizer to pulverize, and then pass through an 80-mesh sieve after pulverization;

[0034] (2) Granulation: add the sieved raw materials in step (1) into the high-efficiency wet granulator and mix them evenly, add...

Embodiment 3

[0038] A dry suspension of azithromycin comprising the following raw materials: 100 parts of azithromycin, 60 parts of sodium citrate, 90 parts of sodium carboxymethylcellulose, 1724 parts of powdered sugar and 26 parts of sweet orange essence;

[0039] Among them, azithromycin is the main drug, sodium citrate is the flocculant, sodium carboxymethylcellulose is the suspending agent, powdered sugar is the suspending agent and flavoring agent, and sweet orange essence is the aromatic agent.

[0040] The preparation method of above-mentioned azithromycin dry suspension comprises the following steps:

[0041] (1) Crushing and sieving: Azithromycin, sodium citrate, sodium carboxymethylcellulose, and powdered sugar are respectively added into the hopper of the universal pulverizer to pulverize, and then pass through an 80-mesh sieve after pulverization;

[0042] (2) Granulation: add the sieved raw materials in step (1) into the high-efficiency wet granulator and mix them evenly, add...

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Abstract

The invention discloses an azithromycin dry suspension and a preparation method thereof. The azithromycin dry suspension is prepared from the following raw materials in parts by weight: 100 parts of azithromycin, 55-65 parts of sodium citrate, 85-95 parts of sodium carboxymethylcellulose, 1700-1750 parts of powdered sugar and 24-28 parts of an orange flavor, wherein the azithromycin is taken as a main drug, the sodium citrate is taken as a flocculating agent, the sodium carboxymethylcellulose is taken as a suspending agent, the powdered sugar is taken as a suspending agent and a flavoring agent and the orange flavor is taken as a flavoring agent. The prepared azithromycin dry suspension is excellent in various detection results, especially relatively low in content of related substances and excellent in settlement volume ratio, the drug effect of the azithromycin can be better developed, the effective rate of the drug is improved, the azithromycin dry suspension has sweet taste, regurgitation caused by a too bitter drug is avoided and the azithromycin dry suspension is suitable taking by children, old people and kinds of groups.

Description

technical field [0001] The invention relates to the technical field of azithromycin, in particular to a dry suspension of azithromycin and a preparation method thereof. Background technique [0002] Azithromycin is mainly used for respiratory tract, skin and soft tissue infections caused by sensitive bacteria and sexually transmitted diseases caused by chlamydia. The effective rate for acute bronchitis, chronic obstructive pulmonary disease co-infection, pneumonia, etc. caused by influenza bacillus, pneumococcus and Morakata bacteria is 90%, and the bacterial clearance rate is 85%. For boils and cellulitis caused by Streptococcus pyogenes, Staphylococcus aureus, etc., use this product once a day for 5 days (total amount 1.5g), the cure rate is 53% to 74%, and the effective rate is up to More than 90%, its curative effect is similar to that of oxacillin, erythromycin and cephalexin. A single dose of 1 g is similar to ciprofloxacin or doxycycline in the treatment of chlamydi...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K47/12A61K47/38A61K47/26A61K47/10A61K9/20A61K31/7052A61P31/04
CPCA61K9/1617A61K9/1623A61K9/1652A61K9/2095A61K31/7052
Inventor 张丽杰刘全胜
Owner HAINAN JINXING PHARMA
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